PMID- 32147032
OWN - NLM
STAT- MEDLINE
DCOM- 20200924
LR  - 20200924
IS  - 1873-6963 (Electronic)
IS  - 0965-2299 (Linking)
VI  - 49
DP  - 2020 Mar
TI  - The effect of intramuscular megadose of vitamin D injections on E-selectin, CRP 
      and biochemical parameters in vitamin D-deficient patients with type-2 diabetes 
      mellitus: A randomized controlled trial.
PG  - 102346
LID - S0965-2299(19)31733-9 [pii]
LID - 10.1016/j.ctim.2020.102346 [doi]
AB  - BACKGROUND AND AIMS: Inflammatory processes has been shown to be associated with 
      the development of type 2 diabetes mellitus (T2DM) in which vitamin D 
      supplementation might exert beneficial outcomes. We examined the effects of 
      vitamin D supplement on inflammatory and cell adhesion molecule in patients with 
      T2DM. METHODS: This study consisted of 50 patients with T2DM who had vitamin D 
      deficiency. Participants were randomized into two groups of 25 in which the 
      intervention group received two intramuscular injections of a 200000-IU vitamin D 
      supplement, one at week 0 and another at week 4. The concentrations of fasting 
      blood glucose (FBG), lipid profiles, liver enzymes, E-selectin, C-reactive 
      protein (CRP), calcium, phosphorus, serum 25-hydroxyvitamin D [25(OH)D] and 
      anthropometric indices were obtained before and after 8 weeks. RESULTS: Vitamin D 
      resulted in significant reductions in CRP(P = 0.01) and gamma glutamyl 
      transferase (GGT) levels(P = 0.03) and significant increases in 25(OH)D 
      concentrations(P = 0.01) in the intervention group compared with the control. 
      Within-group comparisons showed that FBG decreased significantly in the 
      intervention group(P = 0.04). No significant changes were observed regarding 
      within- and between-group comparisons of the other markers. CONCLUSION: Vitamin D 
      had beneficial effects on the levels of CRP, serum 25(OH)D and GGT among vitamin 
      D deficient patients with T2DM. (http://www.irct.ir: IRCT2017100336539N1).
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Mirzavandi, Farhang
AU  - Mirzavandi F
AD  - Nutrition and Food Security Research Center, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran; Department of Nutrition, School of Public Health, 
      Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address: 
      farhangfm1371@gmail.com.
FAU - Talenezhad, Nasir
AU  - Talenezhad N
AD  - Nutrition and Food Security Research Center, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran; Department of Nutrition, School of Public Health, 
      Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address: 
      n.talenezhad@gmail.com.
FAU - Razmpoosh, Elham
AU  - Razmpoosh E
AD  - Nutrition and Food Security Research Center, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran; Department of Nutrition, School of Public Health, 
      Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address: 
      e_razmpoosh@yahoo.com.
FAU - Nadjarzadeh, Azadeh
AU  - Nadjarzadeh A
AD  - Department of Nutrition, School of Public Health, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran. Electronic address: azadehnajarzadeh@gmail.com.
FAU - Mozaffari-Khosravi, Hassan
AU  - Mozaffari-Khosravi H
AD  - Department of Nutrition, School of Public Health, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran; Yazd Diabetes Research Center, Shahid Sadoughi 
      University of Medical Sciences, Yazd, Iran. Electronic address: 
      Mozaffari.kh@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200225
PL  - Scotland
TA  - Complement Ther Med
JT  - Complementary therapies in medicine
JID - 9308777
RN  - 0 (Biomarkers)
RN  - 0 (E-Selectin)
RN  - 0 (SELE protein, human)
RN  - 1406-16-2 (Vitamin D)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*analysis
MH  - Diabetes Mellitus, Type 2/*blood
MH  - E-Selectin/*blood
MH  - Female
MH  - Humans
MH  - Injections, Intramuscular
MH  - Male
MH  - Middle Aged
MH  - Vitamin D/*administration & dosage
MH  - Vitamin D Deficiency/*drug therapy
OTO - NOTNLM
OT  - E-selectin
OT  - Randomized controlled trial
OT  - Type 2 diabetes mellitus
OT  - Vitamin D
COIS- Declaration of Competing Interest The authors declare that they have no competing 
      interests.
EDAT- 2020/03/10 06:00
MHDA- 2020/09/25 06:00
CRDT- 2020/03/10 06:00
PHST- 2019/11/11 00:00 [received]
PHST- 2019/12/30 00:00 [revised]
PHST- 2020/02/11 00:00 [accepted]
PHST- 2020/03/10 06:00 [entrez]
PHST- 2020/03/10 06:00 [pubmed]
PHST- 2020/09/25 06:00 [medline]
AID - S0965-2299(19)31733-9 [pii]
AID - 10.1016/j.ctim.2020.102346 [doi]
PST - ppublish
SO  - Complement Ther Med. 2020 Mar;49:102346. doi: 10.1016/j.ctim.2020.102346. Epub 
      2020 Feb 25.