PMID- 32147433
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2050-1161 (Print)
IS  - 2050-1161 (Electronic)
IS  - 2050-1161 (Linking)
VI  - 8
IP  - 2
DP  - 2020 Jun
TI  - Effect of Icariside II and Metformin on Penile Erectile Function, Histological 
      Structure, Mitochondrial Autophagy, Glucose-Lipid Metabolism, Angiotensin II and 
      Sex Hormone in Type 2 Diabetic Rats With Erectile Dysfunction.
PG  - 168-177
LID - S2050-1161(20)30020-9 [pii]
LID - 10.1016/j.esxm.2020.01.006 [doi]
AB  - INTRODUCTION: Type 2 diabetes mellitus erectile dysfunction (T2DMED) is one of 
      the common complications of type 2 diabetes mellitus (T2DM). Icariside II (ICA 
      II), a flavonoid derived from Epimedium, has been shown to improve erectile 
      function in T2DMED rats. AIM: To investigate the effect of ICA II and metformin 
      (MET) on penile erectile function, mitochondrial autophagy, glucose-lipid 
      metabolism in rats with T2DMED. METHODS: In the control and T2DMED groups, rats 
      were administered normal saline. In the MET group, rats were administered MET for 
      0.2 g/kg/day. In the ICA II+MET group, rats were administered ICA II for 
      10 mg/kg/day and MET for 0.2 g/kg/day. RESULTS: The number of mating rats, number 
      of erectile rats, erection rate, erection frequency, intracorneal pressure, and 
      intracorneal pressure/mean arterial pressure in the ICA II+MET group and control 
      group were significantly higher than corresponding values in than T2DMED group. 
      The absolute values of fasting plasma glucose, glycated haemoglobin in the ICA 
      II+MET group, MET group, and control group were significantly lower than in the 
      T2DMED group. The advanced glycation end product (AGE) values in the ICA II+MET 
      group and the MET group were lower than in the T2DMED group. The receptors for 
      the AGE values and angiotensin II values in the ICA II+MET group were lower than 
      in the T2DMED and MET groups. The high-density lipoprotein values, testosterone 
      values, nitric oxide synthase activity, and cyclic guanosine monophosphate 
      content in the ICA II+MET and control groups were higher than in the T2DMED 
      group. The low-density lipoprotein values, triglyceride values, estradiol values, 
      and total cholesterol values in the ICA II+MET and control groups were lower than 
      in the T2DMED group. CONCLUSION: ICA II could increase erectile function and 
      smooth muscle cell/collagen fibril proportions, decreased mitochondrial 
      autophagy, and AGE concentrations and improve lipid metabolism, nitric oxide 
      synthase activity, cyclic guanosine monophosphate content, testosterone, 
      estradiol, and Ang II in rat with T2DMED. Zhang J, Li S, Zhang S, et al. Effect 
      of Icariside II and Metformin on Penile Erectile Function, Histological 
      Structure, Mitochondrial Autophagy, Glucose-Lipid Metabolism, Angiotensin II and 
      Sex Hormone in Type 2 Diabetic Rats With Erectile Dysfunction. J Sex Med 
      2020;8:168-177.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Zhang, Jian
AU  - Zhang J
AD  - Beijing Geriatric Hospital, Department of Urology, Beijing, China.
FAU - Li, Shuang
AU  - Li S
AD  - Beijing Tong Ren Hospital, Capital Medical University, Department of Urology, 
      Beijing, China.
FAU - Zhang, Shiqing
AU  - Zhang S
AD  - Beijing Geriatric Hospital, Department of Urology, Beijing, China.
FAU - Wang, Yonghui
AU  - Wang Y
AD  - Beijing Tong Ren Hospital, Capital Medical University, Department of Urology, 
      Beijing, China.
FAU - Jin, Shipeng
AU  - Jin S
AD  - Beijing Tong Ren Hospital, Capital Medical University, Department of Urology, 
      Beijing, China.
FAU - Zhao, Chunli
AU  - Zhao C
AD  - Affiliated Hospital of Hebei University, Department of Urology, Baoding, Hebei, 
      China.
FAU - Yang, Wenzeng
AU  - Yang W
AD  - Affiliated Hospital of Hebei University, Department of Urology, Baoding, Hebei, 
      China.
FAU - Liu, Yuexin
AU  - Liu Y
AD  - Beijing Tong Ren Hospital, Capital Medical University, Department of Urology, 
      Beijing, China. Electronic address: doctorlyx@126.com.
FAU - Kong, Guangqi
AU  - Kong G
AD  - Beijing Lu He Hospital, Capital Medical University, Department of Urology, 
      Beijing, China. Electronic address: summerharvest11@163.com.
LA  - eng
PT  - Journal Article
DEP - 20200305
PL  - England
TA  - Sex Med
JT  - Sexual medicine
JID - 101631053
PMC - PMC7261708
OTO - NOTNLM
OT  - Glucose-lipid Metabolism
OT  - Icariside Ⅱ
OT  - Mitochondrial Autophagy
OT  - Sex Hormone
OT  - Sexual function
EDAT- 2020/03/10 06:00
MHDA- 2020/03/10 06:01
PMCR- 2020/03/05
CRDT- 2020/03/10 06:00
PHST- 2019/09/22 00:00 [received]
PHST- 2020/01/07 00:00 [revised]
PHST- 2020/01/27 00:00 [accepted]
PHST- 2020/03/10 06:00 [pubmed]
PHST- 2020/03/10 06:01 [medline]
PHST- 2020/03/10 06:00 [entrez]
PHST- 2020/03/05 00:00 [pmc-release]
AID - S2050-1161(20)30020-9 [pii]
AID - 10.1016/j.esxm.2020.01.006 [doi]
PST - ppublish
SO  - Sex Med. 2020 Jun;8(2):168-177. doi: 10.1016/j.esxm.2020.01.006. Epub 2020 Mar 5.