PMID- 32147765
OWN - NLM
STAT- MEDLINE
DCOM- 20210201
LR  - 20210201
IS  - 1573-8221 (Electronic)
IS  - 0007-4888 (Linking)
VI  - 168
IP  - 4
DP  - 2020 Feb
TI  - Glial Fibrillary Acidic Protein in the Diagnosis and Prognosis of Malignant Glial 
      Tumors.
PG  - 503-506
LID - 10.1007/s10517-020-04741-9 [doi]
AB  - Serum levels of glial fibrillar acidic protein (GFAP) were analyzed in 317 
      patients with primary and metastatic tumors of the brain, 78 patients with 
      neurological diseases, and 66 normal subjects. A significant increase in the 
      basal level of GFAP was typical of patients with glioblastomas in comparison with 
      other groups (patients with astrocytomas, cerebral metastases, benign tumors, 
      non-tumor diseases, and healthy subjects). An association of GFAP levels with 
      unfavorable prognosis of overall survival in patients with glioblastoma was 
      revealed. The data attest to high specificity and sensitivity of GFAP as a 
      biochemical marker of glioblastoma.
FAU - Lyubimova, N V
AU  - Lyubimova NV
AD  - N. N. Blokhin National Research Medical Center of Oncology, Ministry of Health of 
      the Russian Federation, Moscow, Russia. biochimia@yandex.ru.
FAU - Timofeev, Yu S
AU  - Timofeev YS
AD  - N. N. Blokhin National Research Medical Center of Oncology, Ministry of Health of 
      the Russian Federation, Moscow, Russia.
FAU - Mitrofanov, A A
AU  - Mitrofanov AA
AD  - N. N. Blokhin National Research Medical Center of Oncology, Ministry of Health of 
      the Russian Federation, Moscow, Russia.
FAU - Bekyashev, A Kh
AU  - Bekyashev AK
AD  - N. N. Blokhin National Research Medical Center of Oncology, Ministry of Health of 
      the Russian Federation, Moscow, Russia.
FAU - Goncharova, Z A
AU  - Goncharova ZA
AD  - Clinical Department of Rostov State Medical University, Ministry of Health of the 
      Russian Federation, Rostov-on-Don, Russia.
FAU - Kushlinskii, N E
AU  - Kushlinskii NE
AD  - N. N. Blokhin National Research Medical Center of Oncology, Ministry of Health of 
      the Russian Federation, Moscow, Russia.
LA  - eng
PT  - Journal Article
DEP - 20200309
PL  - United States
TA  - Bull Exp Biol Med
JT  - Bulletin of experimental biology and medicine
JID - 0372557
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (GFAP protein, human)
RN  - 0 (Glial Fibrillary Acidic Protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/blood/diagnosis/genetics
MH  - Astrocytoma/blood/diagnosis/*genetics/mortality
MH  - Biomarkers, Tumor/blood/*genetics
MH  - Brain/metabolism/pathology
MH  - Brain Neoplasms/blood/diagnosis/*genetics/mortality
MH  - Case-Control Studies
MH  - Female
MH  - Glial Fibrillary Acidic Protein/blood/*genetics
MH  - Glioblastoma/blood/diagnosis/*genetics/mortality
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/blood/diagnosis/genetics
MH  - Neuroglia/metabolism/pathology
MH  - Parkinson Disease/blood/diagnosis/genetics
MH  - Prognosis
MH  - Survival Analysis
OTO - NOTNLM
OT  - diagnosis
OT  - glial fibrillary acidic protein (GFAP)
OT  - glioblastoma
OT  - neurological diseases of the brain
OT  - prognosis
EDAT- 2020/03/10 06:00
MHDA- 2021/02/02 06:00
CRDT- 2020/03/10 06:00
PHST- 2019/08/02 00:00 [received]
PHST- 2020/03/10 06:00 [pubmed]
PHST- 2021/02/02 06:00 [medline]
PHST- 2020/03/10 06:00 [entrez]
AID - 10.1007/s10517-020-04741-9 [pii]
AID - 10.1007/s10517-020-04741-9 [doi]
PST - ppublish
SO  - Bull Exp Biol Med. 2020 Feb;168(4):503-506. doi: 10.1007/s10517-020-04741-9. Epub 
      2020 Mar 9.