PMID- 32148243
OWN - NLM
STAT- MEDLINE
DCOM- 20200408
LR  - 20200408
IS  - 2095-4352 (Print)
VI  - 32
IP  - 1
DP  - 2020 Jan
TI  - [Advance in research of microRNA-21-5p regulate autophagy by targeting gene].
PG  - 112-117
LID - 10.3760/cma.j.cn121430-20190925-00021 [doi]
AB  - Autophagy is a dynamic process that degrades intracellular proteins and damaged 
      organelles, and maintains environmental stability within the cell and provides 
      good conditions for cell survival. Hyperoxic acute lung injury (HALI) is one of 
      the serious complications of clinical oxygen therapy. The pathogenesis of HALI is 
      still unclear. There are studies having shown that autophagy is involved in the 
      pathogenesis of HALI. There are many pathway mechanisms that regulate autophagy, 
      including phosphatidylinositol-3-kinase/Akt/mammalian target of rapamycin 
      (PI3K/Akt/mTOR) signaling pathway, mitogen-activated protein kinase/extracellular 
      signaling-regulated protein kinase (MAPK/ERK) signaling pathway, adenosine 
      5'-monophosphate-activated protein kinase/unc-51 like autophagy activating kinase 
      1 (AMPK/ULK1) signaling pathway, transforming growth factor beta (TGF-beta) and 
      forkhead box O1 (FoxO1) and Ras guanosine triphosphatease superfamily member 
      Rab11a, each of which is referred to as microRNA-21-5p (miR-21-5p) target gene 
      having a role in regulating autophagy activity in many diseases. In this paper, 
      the above-mentioned signaling pathways of miRNA-21-5p target genes regulating 
      autophagy were reviewed in order to find clues about the mechanism of miRNA-21-5p 
      regulating autophagy in HALI and provide a theoretical basis for subsequent basic 
      research.
FAU - Liu, Xinxin
AU  - Liu X
AD  - Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical 
      University, Zunyi 563000, Guizhou, China. Corresponding author: Chen Miao, Email: 
      chenmiao64@163.com.
FAU - Chen, Miao
AU  - Chen M
FAU - Chen, Bowen
AU  - Chen B
FAU - Feng, Banghai
AU  - Feng B
LA  - chi
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
JT  - Zhonghua wei zhong bing ji jiu yi xue
JID - 101604552
RN  - 0 (MIRN21 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - *Autophagy
MH  - Cell Survival
MH  - Humans
MH  - MicroRNAs/*genetics
MH  - Phosphatidylinositol 3-Kinases
MH  - *Signal Transduction
EDAT- 2020/03/10 06:00
MHDA- 2020/04/09 06:00
CRDT- 2020/03/10 06:00
PHST- 2020/03/10 06:00 [entrez]
PHST- 2020/03/10 06:00 [pubmed]
PHST- 2020/04/09 06:00 [medline]
AID - 10.3760/cma.j.cn121430-20190925-00021 [doi]
PST - ppublish
SO  - Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2020 Jan;32(1):112-117. doi: 
      10.3760/cma.j.cn121430-20190925-00021.