PMID- 32149046
OWN - NLM
STAT- MEDLINE
DCOM- 20210506
LR  - 20210506
IS  - 2291-2797 (Electronic)
IS  - 2291-2789 (Print)
IS  - 2291-2789 (Linking)
VI  - 2020
DP  - 2020
TI  - Bredemolic Acid Ameliorates Selected Liver Function Biomarkers in a Diet-Induced 
      Prediabetic Rat Model.
PG  - 2475301
LID - 10.1155/2020/2475301 [doi]
LID - 2475301
AB  - BACKGROUND: Prediabetes is an intermediary hyperglycaemic state that precedes 
      type 2 diabetes mellitus (T2DM) in which abnormal metabolism of glucose and 
      lipids occurs in organs such as the liver. Evidence has shown that, about 70% of 
      T2DM patients develop hepatic dysfunction which is found to begin during the 
      prediabetic stage. Bredemolic acid, a pentacyclic triterpene, has been found to 
      improve insulin sensitivity in diet-induced prediabetic rats. The effects of this 
      compound on liver function, however, are unknown. This study was therefore 
      designed to investigate the effects of BA on liver function in high fat-high 
      carbohydrate (HFHC) diet-induced prediabetic rats. METHODS: Thirty-six (36) male 
      rats that weigh 150 g-180 g were divided into two groups, the non-prediabetic 
      (n = 6) and the prediabetic groups (n = 6) and the prediabetic groups (n = 6) and 
      the prediabetic groups (. RESULTS: The induction of prediabetes resulted in 
      increased release of liver enzymes (AST and ALT), increased liver glycogen and 
      triglyceride, lipid peroxidation, and decreased sterol regulatory element-binding 
      protein (SREBP1c) and antioxidant enzymes. However, the administration of BA 
      decreased liver enzyme concentrations, decreased hepatic oxidative stress, and 
      improved antioxidant enzymes such as SOD and GPx. CONCLUSION: BA administration 
      improved liver function in diet-induced prediabetic rats in the presence or 
      absence of dietary intervention.
CI  - Copyright (c) 2020 Akinjide Moses Akinnuga et al.
FAU - Akinnuga, Akinjide Moses
AU  - Akinnuga AM
AUID- ORCID: 0000-0001-7855-8176
AD  - Department of Physiology, School of Laboratory Medicine and Medical Sciences, 
      College of Health Sciences, University of KwaZulu-Nata, Westville, Durban, South 
      Africa.
FAU - Siboto, Angezwa
AU  - Siboto A
AUID- ORCID: 0000-0001-9845-2301
AD  - Department of Physiology, School of Laboratory Medicine and Medical Sciences, 
      College of Health Sciences, University of KwaZulu-Nata, Westville, Durban, South 
      Africa.
FAU - Khumalo, Bongiwe
AU  - Khumalo B
AD  - Department of Physiology, School of Laboratory Medicine and Medical Sciences, 
      College of Health Sciences, University of KwaZulu-Nata, Westville, Durban, South 
      Africa.
FAU - Sibiya, Ntethelelo Hopewell
AU  - Sibiya NH
AD  - Department of Pharmacy and Pharmacology, Rhodes University, Grahamstown, South 
      Africa.
FAU - Ngubane, Phikelelani
AU  - Ngubane P
AUID- ORCID: 0000-0003-2150-1149
AD  - Department of Physiology, School of Laboratory Medicine and Medical Sciences, 
      College of Health Sciences, University of KwaZulu-Nata, Westville, Durban, South 
      Africa.
FAU - Khathi, Andile
AU  - Khathi A
AUID- ORCID: 0000-0002-2246-0038
AD  - Department of Physiology, School of Laboratory Medicine and Medical Sciences, 
      College of Health Sciences, University of KwaZulu-Nata, Westville, Durban, South 
      Africa.
LA  - eng
PT  - Journal Article
DEP - 20200220
PL  - Egypt
TA  - Can J Gastroenterol Hepatol
JT  - Canadian journal of gastroenterology & hepatology
JID - 101623613
RN  - 0 (Biomarkers)
RN  - 0 (Triterpenes)
RN  - E233J88OHQ (maslinic acid)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Diet, Carbohydrate Loading/adverse effects
MH  - Diet, High-Fat/adverse effects
MH  - Disease Models, Animal
MH  - Insulin Resistance/physiology
MH  - Liver/*drug effects
MH  - Liver Function Tests
MH  - Male
MH  - Oxidative Stress/drug effects
MH  - Prediabetic State/*drug therapy
MH  - Rats
MH  - Triterpenes/*pharmacology
PMC - PMC7053450
COIS- The authors declare no conflicts of interest.
EDAT- 2020/03/10 06:00
MHDA- 2021/05/07 06:00
PMCR- 2020/02/20
CRDT- 2020/03/10 06:00
PHST- 2019/08/29 00:00 [received]
PHST- 2019/12/21 00:00 [revised]
PHST- 2020/01/06 00:00 [accepted]
PHST- 2020/03/10 06:00 [entrez]
PHST- 2020/03/10 06:00 [pubmed]
PHST- 2021/05/07 06:00 [medline]
PHST- 2020/02/20 00:00 [pmc-release]
AID - 10.1155/2020/2475301 [doi]
PST - epublish
SO  - Can J Gastroenterol Hepatol. 2020 Feb 20;2020:2475301. doi: 10.1155/2020/2475301. 
      eCollection 2020.