PMID- 32149149
OWN - NLM
STAT- MEDLINE
DCOM- 20201216
LR  - 20220413
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2020
DP  - 2020
TI  - Clinicopathological Analysis of Five Cases of NUT Midline Carcinoma, including 
      One with the Gingiva.
PG  - 9791208
LID - 10.1155/2020/9791208 [doi]
LID - 9791208
AB  - AIMS: NUT midline carcinoma (NMC) is a rare, poorly differentiated carcinoma 
      defined by the presence of NUT gene rearrangement. In order to better understand 
      the diagnostic and clinicopathologic features of this disease as they pertain to 
      clinical practice, we have herein compiled findings pertaining to 5 cases of NMC 
      at our institution. METHODS: Clinicopathological findings from 5 NMC cases were 
      retrospectively reviewed, with histologic findings being reassessed and 
      summarized accordingly. Tumor samples in the present study had been stained for 
      markers including NUT, P63, P40, TTF-1, keratin, CK7, Syn, CD56, CgA, CD34, 
      CD117, EGFR, and Ki-67. All cases were subjected to both fluorescence in situ 
      hybridization (FISH) and followed up. RESULTS: Of these 5 NMC cases, 2 were males 
      and 3 were females, with ages ranging from 26 to 69 years. A total of 2 cases 
      localized to the lung, 1 to the larynx, 1 to the maxillary gingiva, and 1 to the 
      orbital cavity. Upon microscopic assessment, these tumors appeared as clusters of 
      small rounded cells with interstitial neutrophil infiltration. Squamous 
      epithelial differentiation varied between samples. NUT staining revealed strong 
      diffuse nuclear staining in tumor cells, and FISH confirmed the presence of NUT 
      gene translocation in these samples. CONCLUSIONS: NMC is a form of highly 
      invasive cancer that can manifest in a number of tissues including the gingiva. 
      NMC tumors have a fairly well-defined pathological morphology, and both 
      immunohistochemistry and FISH are valuable for NMC diagnosis.
CI  - Copyright (c) 2020 Luting Zhou et al.
FAU - Zhou, Luting
AU  - Zhou L
AD  - Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of 
      Medicine, Shanghai 200025, China.
FAU - Yong, Xiang
AU  - Yong X
AD  - Department of Pathology, The Third Affiliated Hospital of Bengbu Medical College, 
      Suzhou 234000, China.
FAU - Zhou, Jun
AU  - Zhou J
AUID- ORCID: 0000-0002-3823-7615
AD  - Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of 
      Medicine, Shanghai 200025, China.
FAU - Xu, Jiankun
AU  - Xu J
AD  - Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of 
      Medicine, Shanghai 200025, China.
FAU - Wang, Chaofu
AU  - Wang C
AUID- ORCID: 0000-0002-5956-9328
AD  - Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of 
      Medicine, Shanghai 200025, China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20200213
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Antineoplastic Agents)
RN  - 0 (NUTM1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Nuclear Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antineoplastic Agents/therapeutic use
MH  - *Carcinoma/diagnosis/drug therapy/genetics/pathology
MH  - Fatal Outcome
MH  - Female
MH  - *Head and Neck Neoplasms/diagnosis/drug therapy/genetics/pathology
MH  - Humans
MH  - *Lung Neoplasms/diagnosis/drug therapy/genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/genetics
MH  - Nuclear Proteins/genetics
MH  - Retrospective Studies
PMC - PMC7042505
COIS- The authors declare that there are no conflicts of interest regarding the 
      publication of this paper.
EDAT- 2020/03/10 06:00
MHDA- 2020/12/17 06:00
PMCR- 2020/02/13
CRDT- 2020/03/10 06:00
PHST- 2019/10/19 00:00 [received]
PHST- 2020/01/27 00:00 [accepted]
PHST- 2020/03/10 06:00 [entrez]
PHST- 2020/03/10 06:00 [pubmed]
PHST- 2020/12/17 06:00 [medline]
PHST- 2020/02/13 00:00 [pmc-release]
AID - 10.1155/2020/9791208 [doi]
PST - epublish
SO  - Biomed Res Int. 2020 Feb 13;2020:9791208. doi: 10.1155/2020/9791208. eCollection 
      2020.