PMID- 32150106
OWN - NLM
STAT- MEDLINE
DCOM- 20200316
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 10
DP  - 2020 Mar
TI  - Molecular sensitization patterns in birch pollen-sensitized Korean children 
      according to the presence of oral allergy syndrome.
PG  - e19469
LID - 10.1097/MD.0000000000019469 [doi]
LID - e19469
AB  - The profiles of sensitization based on component-resolved diagnosis (CRD) differ 
      from region to region in populations sensitized to birch pollen. We investigated 
      the endotypes of birch pollen-sensitized Korean children with allergic diseases 
      using CRD and distinguished the endotypes of oral allergy syndrome (OAS) among 
      them.Thirty-one birch pollen-sensitized children with allergic diseases were 
      enrolled. Specific immunoglobulin E (IgE) to birch pollen and fruit including 
      apple, peach, and kiwi were evaluated via skin prick tests and ImmunoCAP in all 
      subjects. Sensitization profiles based on CRD were evaluated with the 
      Immuno-solid-phase Allergen Chip for birch pollen-sensitization using birch 
      pollen components (Bet v 1, Bet v 2, and Bet v 4), and for OAS using the allergen 
      families pathogenesis-related class 10 proteins (PR-10), lipid transfer proteins, 
      and profilin.All patients (n = 13) with OAS were sensitive to Bet v 1. However, 
      61% (11/18) of patients without OAS were sensitized to Bet v 1. The level of 
      specific IgE to Bet v 1 was higher in patients with OAS than in those without 
      OAS. All birch pollen-sensitized Korean children with OAS were sensitized to 
      PR-10, and 69% (9/13) of them were mono-sensitized to PR-10. Among patients 
      without OAS, 33% (6/18) were not sensitized to any of the allergen families.Birch 
      pollen-sensitized Korean children with allergic diseases showed unique patterns 
      of sensitization to Bet v 1, Bet v 2, and Bet v 4, and the sensitization profiles 
      based on CRD were totally different according to the presence of OAS.
FAU - Baek, Hey-Sung
AU  - Baek HS
AD  - Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, 
      Seoul.
FAU - Jeong, Jae-Won
AU  - Jeong JW
AD  - Inje University Ilsan Paik Hospital, Goyang.
FAU - Lee, Ha-Baik
AU  - Lee HB
AD  - Department of Pediatrics, Hanyang University Hospital, Seoul.
FAU - Kwon, Jae-Woo
AU  - Kwon JW
AD  - Division of Allergy and Clinical Immunology, Kangwon National University School 
      of Medicine, Chuncheon, Republic of Korea.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Allergens)
SB  - IM
MH  - Adolescent
MH  - Allergens/*immunology
MH  - Betula/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Cross Reactions
MH  - Female
MH  - Food Hypersensitivity/complications/*immunology
MH  - Fruit/immunology
MH  - Humans
MH  - Male
MH  - Pollen/*immunology
MH  - Reproducibility of Results
MH  - Republic of Korea
MH  - Sensitivity and Specificity
MH  - Skin Tests
PMC - PMC7478691
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2020/03/10 06:00
MHDA- 2020/03/17 06:00
PMCR- 2020/03/06
CRDT- 2020/03/10 06:00
PHST- 2020/03/10 06:00 [entrez]
PHST- 2020/03/10 06:00 [pubmed]
PHST- 2020/03/17 06:00 [medline]
PHST- 2020/03/06 00:00 [pmc-release]
AID - 00005792-202003060-00062 [pii]
AID - MD-D-19-05912 [pii]
AID - 10.1097/MD.0000000000019469 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Mar;99(10):e19469. doi: 10.1097/MD.0000000000019469.