PMID- 32150482
OWN - NLM
STAT- MEDLINE
DCOM- 20210521
LR  - 20220420
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 31
IP  - 2
DP  - 2021 Mar
TI  - Association between Functional Independence Measure and mortality in patients 
      with anti-neutrophil cytoplasmic antibody-associated vasculitis: A single-center 
      observational study.
PG  - 399-407
LID - 10.1080/14397595.2020.1740393 [doi]
AB  - OBJECTIVES: Previous studies have identified several predictors of mortality in 
      patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). 
      However, functional dependence as a predictor of mortality has never been 
      reported. In this study, we investigated whether Functional Independence Measure 
      (FIM) was associated with mortality in AAV patients. METHODS: We analyzed 52 
      adults with biopsy-proven AAV in Teine Keijinkai Medical Center between January 
      2000 and March 2019. Adjusted Cox regression analyses were conducted to evaluate 
      the association between three FIM-based groups and all-cause mortality. Estimates 
      were calculated as hazard ratios with 95% confidence intervals (95% CIs). 
      RESULTS: During a median follow-up of 2.3 years (interquartile range, 0.7-4.6 
      years), death occurred in 15 patients (29%). Compared to the highest-FIM group 
      (91-126 points), the adjusted hazard ratios for the intermediate- (55-90 points) 
      and lowest-FIM (18-54 points) groups were 3.59 (95% CIs, 0.40-32.0) and 15.7 (95% 
      CIs, 2.07-119) for all-cause mortality, respectively. In addition, the lower-FIM 
      groups were associated with higher mortality (p=.0179). CONCLUSION: This study 
      suggested that the FIM score is a predictor of all-cause mortality in AAV 
      patients. Future studies will have to investigate whether FIM assessment leads to 
      better outcomes.
FAU - Shimamura, Yoshinosuke
AU  - Shimamura Y
AUID- ORCID: 0000-0003-0278-6900
AD  - Department of Nephrology, Teine Keijinkai Medical Center, Sapporo, Japan.
FAU - Maeda, Takuto
AU  - Maeda T
AD  - Department of Nephrology, Teine Keijinkai Medical Center, Sapporo, Japan.
FAU - Abe, Koki
AU  - Abe K
AD  - Department of Nephrology, Teine Keijinkai Medical Center, Sapporo, Japan.
FAU - Ogawa, Yayoi
AU  - Ogawa Y
AD  - Hokkaido Renal Pathology Center, Sapporo, Japan.
FAU - Takizawa, Hideki
AU  - Takizawa H
AD  - Department of Nephrology, Teine Keijinkai Medical Center, Sapporo, Japan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20200324
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*mortality
MH  - Female
MH  - *Functional Status
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
OTO - NOTNLM
OT  - Anti-neutrophil cytoplasmic antibody-associated vasculitis
OT  - Functional Independence Measure
OT  - vasculitis mortality
EDAT- 2020/03/10 06:00
MHDA- 2021/05/22 06:00
CRDT- 2020/03/10 06:00
PHST- 2020/03/10 06:00 [pubmed]
PHST- 2021/05/22 06:00 [medline]
PHST- 2020/03/10 06:00 [entrez]
AID - 10.1080/14397595.2020.1740393 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2021 Mar;31(2):399-407. doi: 10.1080/14397595.2020.1740393. Epub 
      2020 Mar 24.