PMID- 32150670
OWN - NLM
STAT- MEDLINE
DCOM- 20201111
LR  - 20201111
IS  - 1099-0496 (Electronic)
IS  - 1099-0496 (Linking)
VI  - 55
IP  - 5
DP  - 2020 May
TI  - Effect of pressure rise time on ventilator parameters and gas exchange during 
      neonatal ventilation.
PG  - 1131-1138
LID - 10.1002/ppul.24724 [doi]
AB  - BACKGROUND: Pressure rise time (PRT), also known as slope time to the peak 
      inflating pressure can be set on some modern neonatal ventilators. On other 
      ventilators, PRT is determined by the set circuit flow. Changing slope time can 
      affect mean airway pressure (MAP), oxygenation, and carbon dioxide elimination. 
      Our aim was to investigate the effect of PRT on ventilator parameters and gas 
      exchange during volume-guaranteed ventilation. METHODS: In a crossover study, 12 
      infants weighing greater than 2 kg were ventilated using a Drager Babylog VN500 
      ventilator with synchronized intermittent positive pressure ventilation with 
      volume guarantee (SIPPV-VG) and pressure support ventilation with volume 
      guarantee (PSV-VG). During both modes PRTs between 0.08 and 0.40 seconds were 
      used in 15-minute epochs. Data from the ventilator and patient monitors were 
      downloaded with 1- and 100-Hz sampling rate and analyzed using the Python 
      computer language. RESULTS: During PSV-VG, longer PRTs were associated with 
      longer inspiratory time (P < .0001) and with lower peak inflating pressure (PIP; 
      P = .003), but the MAP was similar. During SIPPV-VG the PIP was not significantly 
      different; however, MAP was lower with longer PRT (P = .001). With a short PRT 
      (0.08 seconds), the PIP was higher during PSV-VG than during SIPPV-VG (19.8 vs 
      16.5 mbar; P = .042). There were no significant differences in tidal volume 
      delivery, respiratory rate, minute volume, oxygen saturations, or end-tidal CO(2) 
      with different PRTs in either mode. CONCLUSIONS: During SIPPV-VG or PSV-VG, using 
      short or long PRTs affects some ventilation parameters but does not significantly 
      change oxygenation or carbon dioxide elimination.
CI  - (c) 2020 Wiley Periodicals, Inc.
FAU - Chong, David
AU  - Chong D
AUID- ORCID: 0000-0002-2013-1935
AD  - Neonatal Intensive Care Unit, The Rosie Hospital, Cambridge University Hospitals 
      NHS Foundation Trust, Cambridge, UK.
AD  - St. Edmund's College, University of Cambridge, Cambridge, UK.
FAU - Kayser, Sabrina
AU  - Kayser S
AD  - Neonatal Intensive Care Unit, The Rosie Hospital, Cambridge University Hospitals 
      NHS Foundation Trust, Cambridge, UK.
FAU - Szakmar, Eniko
AU  - Szakmar E
AUID- ORCID: 0000-0002-8848-8092
AD  - Neonatal Intensive Care Unit, The Rosie Hospital, Cambridge University Hospitals 
      NHS Foundation Trust, Cambridge, UK.
AD  - First Department of Paediatrics, Semmelweis University, Budapest, Hungary.
FAU - Morley, Colin J
AU  - Morley CJ
AUID- ORCID: 0000-0001-5388-0214
AD  - Neonatal Intensive Care Unit, The Rosie Hospital, Cambridge University Hospitals 
      NHS Foundation Trust, Cambridge, UK.
FAU - Belteki, Gusztav
AU  - Belteki G
AUID- ORCID: 0000-0002-2974-2011
AD  - Neonatal Intensive Care Unit, The Rosie Hospital, Cambridge University Hospitals 
      NHS Foundation Trust, Cambridge, UK.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200309
PL  - United States
TA  - Pediatr Pulmonol
JT  - Pediatric pulmonology
JID - 8510590
RN  - 142M471B3J (Carbon Dioxide)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Carbon Dioxide/physiology
MH  - Cross-Over Studies
MH  - Humans
MH  - Infant, Newborn
MH  - Intermittent Positive-Pressure Ventilation/instrumentation/*methods
MH  - Oxygen/physiology
MH  - Pressure
MH  - Respiration
MH  - Respiratory Function Tests
MH  - Ventilators, Mechanical
OTO - NOTNLM
OT  - circuit flow
OT  - mechanical ventilation
OT  - neonatology
OT  - pressure rise time
OT  - slope time
EDAT- 2020/03/10 06:00
MHDA- 2020/11/12 06:00
CRDT- 2020/03/10 06:00
PHST- 2020/01/17 00:00 [received]
PHST- 2020/02/25 00:00 [accepted]
PHST- 2020/03/10 06:00 [pubmed]
PHST- 2020/11/12 06:00 [medline]
PHST- 2020/03/10 06:00 [entrez]
AID - 10.1002/ppul.24724 [doi]
PST - ppublish
SO  - Pediatr Pulmonol. 2020 May;55(5):1131-1138. doi: 10.1002/ppul.24724. Epub 2020 
      Mar 9.