PMID- 32151750 OWN - NLM STAT- MEDLINE DCOM- 20200409 LR - 20200409 IS - 1743-9159 (Electronic) IS - 1743-9159 (Linking) VI - 76 DP - 2020 Apr TI - Comparative analysis of weight loss and resolution of comorbidities between laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass: A systematic review and meta-analysis based on 18 studies. PG - 101-110 LID - S1743-9191(20)30200-4 [pii] LID - 10.1016/j.ijsu.2020.02.035 [doi] AB - BACKGROUND: Laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy are the most common procedures performed in bariatric surgery and both have been demonstrated to have significant effectiveness in treating morbid obesity. However, comparative analysis of their effectiveness has not been well studied. This comparative analysis was conducted to determine whether Laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy have the same mid- and long-term outcomes in weight loss, resolution of obesity comorbidities and adverse events (AEs) of treatment. METHODS: We searched the Cochrane Library, PubMed, Embase and Web of Science databases from the establishment of the database to January 1, 2020 for both randomized control trials and non-randomised interventional studies that studied Laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy with respect to weight loss outcomes, resolution of obesity comorbidities and AEs of treatment. Standardised mean differences, risk ratios and odds ratio with 95% confidence intervals were calculated to compare the outcomes of the groups. Two reviewers assessed the quality of the trials and extracted the data independently. All statistical analyses were performed using the standard statistical procedures in Review Manager 5.2. RESULTS: We included 20 studies (N = 2917 participants) in this meta-analysis. Our results showed no significant difference in excess weight loss between Laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy, with pooled Standardised mean differences of -0.16 (95% confidence interval: -0.52 to 0.19; P = 0.36) based on randomized control trials and 0.07 (95% confidence interval: -0.10 to 0.24; P = 0.41) based on non-randomised interventional studies. Further, the pooled results showed no significant differences in midterm and long-term weight loss outcomes between the comparative groups. Similarly, no significant difference was found in type 2 diabetes mellitus resolution. The pooled results indicated that patients receiving laparoscopic sleeve gastrectomy experienced fewer postoperative complication and reoperation rates, with pooled risk ratios of 1.66 (95% confidence interval: 1.33 to 2.07; P < 0.00001) and 1.73 (95% confidence interval: 1.14 to 2.62; P = 0.01), respectively. Laparoscopic Roux-en-Y gastric bypass was superior to laparoscopic sleeve gastrectomy in managing dyslipidemia, hypertension and gastroesophageal reflux disease. CONCLUSIONS: The present meta-analysis indicated that both Laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy had the same effectiveness in resulting in excess weight loss and type 2 diabetes mellitus resolution. However, patients who received laparoscopic sleeve gastrectomy experienced fewer postoperative complication and reoperation rates than those who received Laparoscopic Roux-en-Y gastric bypass. Laparoscopic Roux-en-Y gastric bypass was superior in the management of dyslipidemia, hypertension and gastroesophageal reflux disease. CI - Copyright (c) 2020. Published by Elsevier Ltd. FAU - Han, Youkui AU - Han Y AD - Department of General Surgery, Tianjin Union Medical Center, Tianjin, 300121, China. FAU - Jia, Yang AU - Jia Y AD - Department of Gerontology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. FAU - Wang, Honglei AU - Wang H AD - Department of General Surgery, Tianjin Union Medical Center, Tianjin, 300121, China. FAU - Cao, Lei AU - Cao L AD - Department of General Surgery, Tianjin Union Medical Center, Tianjin, 300121, China. FAU - Zhao, Yongjie AU - Zhao Y AD - Department of General Surgery, Tianjin Union Medical Center, Tianjin, 300121, China. Electronic address: yhwang1026@126.com. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20200306 PL - United States TA - Int J Surg JT - International journal of surgery (London, England) JID - 101228232 SB - IM CIN - Int J Surg. 2020 May;77:143-144. PMID: 32247088 CIN - Int J Surg. 2020 May;77:128. PMID: 32247091 CIN - Int J Surg. 2020 Jun;78:9-10. PMID: 32302746 CIN - Int J Surg. 2020 Jul;79:64-65. PMID: 32422383 MH - Comorbidity MH - Diabetes Mellitus, Type 2/complications MH - *Gastrectomy/methods MH - *Gastric Bypass/methods MH - Gastroesophageal Reflux/surgery MH - Humans MH - Hypertension/complications MH - Laparoscopy/methods MH - *Obesity, Morbid/surgery MH - Odds Ratio MH - Postoperative Complications/etiology MH - Reoperation MH - Second-Look Surgery MH - *Weight Loss OTO - NOTNLM OT - Bariatric surgery OT - Laparoscopic Roux-en-Y gastric bypass OT - Laparoscopic sleeve gastrectomy OT - Obesity COIS- Declaration of competing interest The authors declare no relevant conflict of interest. EDAT- 2020/03/11 06:00 MHDA- 2020/04/10 06:00 CRDT- 2020/03/11 06:00 PHST- 2019/10/27 00:00 [received] PHST- 2020/02/20 00:00 [revised] PHST- 2020/02/24 00:00 [accepted] PHST- 2020/03/11 06:00 [pubmed] PHST- 2020/04/10 06:00 [medline] PHST- 2020/03/11 06:00 [entrez] AID - S1743-9191(20)30200-4 [pii] AID - 10.1016/j.ijsu.2020.02.035 [doi] PST - ppublish SO - Int J Surg. 2020 Apr;76:101-110. doi: 10.1016/j.ijsu.2020.02.035. Epub 2020 Mar 6.