PMID- 3215302
OWN - NLM
STAT- MEDLINE
DCOM- 19890309
LR  - 20190721
IS  - 0014-4819 (Print)
IS  - 0014-4819 (Linking)
VI  - 73
IP  - 2
DP  - 1988
TI  - Prefrontal stimulus-produced hypotension in rat.
PG  - 249-55
AB  - In 41 rats, bipolar electrical stimulation was administered to various regions of 
      the frontal cortex, including the medial prefrontal cortex (MPFC), lateral 
      prefrontal cortex (LPFC), infralimbic cortex, and convexity cortex. Resulting 
      alterations of blood pressure and heart rate were noted. It was observed that 
      hypotension resulted from stimulation administered to either LPFC, infralimbic 
      cortex or ventral portion of MPFC (i.e. prelimbic cortex). Furthermore, 
      stimulation of the LPFC typically produced bradycardia, whereas stimulation of 
      the MPFC or infralimbic cortex had little or no effect on heart rate. 
      Pharmacological and surgical blocks of the vagus nerves failed to attenuate the 
      stimulus produced hypotension (SPH), as elicited from the prefrontal or 
      infralimbic cortices, thus demonstrating that SPH in rats is not mediated by the 
      vagus nerves. However, intraperitoneal injections of norepinephrine, which 
      mimicked a state of increased sympathetic tone, were observed to completely block 
      SPH. Accordingly, it is suggested that SPH may occur as the result of sympathetic 
      inhibition. Furthermore, intravenous injections of naloxone were also observed to 
      also completely block SPH, thus demonstrating that SPH may be mediated via opioid 
      pathways.
FAU - Hardy, S G
AU  - Hardy SG
AD  - Department of Anatomy, University of Mississippi Medical Center, Jackson 39216.
FAU - Holmes, D E
AU  - Holmes DE
LA  - eng
GR  - 2-S07-RR05386/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adrenergic Fibers/physiology
MH  - Animals
MH  - *Blood Pressure
MH  - Electric Stimulation
MH  - Frontal Lobe/drug effects/*physiology
MH  - Hypotension/*etiology
MH  - Male
MH  - Neural Pathways/physiology
MH  - Norepinephrine/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 10.1007/BF00248217 [doi]
PST - ppublish
SO  - Exp Brain Res. 1988;73(2):249-55. doi: 10.1007/BF00248217.