PMID- 32153246
OWN - NLM
STAT- MEDLINE
DCOM- 20211227
LR  - 20211227
IS  - 1532-2378 (Electronic)
IS  - 1049-5398 (Linking)
VI  - 32
IP  - 5
DP  - 2021 Oct
TI  - A 5-bp mutation within MSTN/GDF8 gene was significantly associated with growth 
      traits in Inner Mongolia White Cashmere goats.
PG  - 610-615
LID - 10.1080/10495398.2020.1736088 [doi]
AB  - Myostatin (MSTN) gene, also known as growth and differentiation factor 8 (GDF8) 
      gene, is a negative regulator of skeletal muscle growth and development, 
      especially the number, size and type of muscle fibers. Its mutations contribute 
      to the double-muscling (DBM) phenomenon which significantly increases the muscle 
      mass. Hence, variations within MSTN/GDF8 gene receive so much attention in 
      several kinds of species such as bovines, poultries, goats, sheep, horses. A 
      5-base pairs (bp) indel in the 5' untranslated region (5'UTR) of goat MSTN/GDF8 
      was verified to be significantly associated with growth traits except Inner 
      Mongolia White Cashmere (IMWC) goats. Given that almost all sample sizes were 
      below 150, we enlarged sample sizes to more than 500 to uncover the association 
      between the 5-bp indel and growth traits in IMWC goats. Only two genotypes 
      (deletion/deletion (DD) and insertion/deletion (ID)) were found, and DD genotypes 
      were dominant genotypes. The detected locus displayed low genetic diversity (PIC 
      = 0.090). Interestingly, the association analyses revealed that the 5-bp indel 
      had a significant effect on the chest depth (p = 0.003), and DD genotypes were 
      dominant genotypes. Hinted that the 5-bp indel could act as an effective marker 
      in molecular marker-assisted selection (MAS) processes for selection of excellent 
      goat individuals.
FAU - Bi, Yi
AU  - Bi Y
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling, 
      P.R. China.
FAU - He, Libang
AU  - He L
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling, 
      P.R. China.
FAU - Feng, Bo
AU  - Feng B
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling, 
      P.R. China.
FAU - Lan, Xianyong
AU  - Lan X
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling, 
      P.R. China.
FAU - Song, Xiaoyue
AU  - Song X
AD  - Shaanxi Provincial Engineering and Technology Research Center of Cashmere Goats, 
      Yulin University, Yulin, China.
AD  - Life Science Research Center, Yulin University, Yulin, China.
FAU - Qu, Lei
AU  - Qu L
AD  - Shaanxi Provincial Engineering and Technology Research Center of Cashmere Goats, 
      Yulin University, Yulin, China.
AD  - Life Science Research Center, Yulin University, Yulin, China.
FAU - Pan, Chuanying
AU  - Pan C
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling, 
      P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20200310
PL  - England
TA  - Anim Biotechnol
JT  - Animal biotechnology
JID - 9011409
RN  - 0 (5' Untranslated Regions)
RN  - 0 (Myostatin)
SB  - IM
MH  - 5' Untranslated Regions
MH  - Animals
MH  - Base Pairing
MH  - China
MH  - Genotype
MH  - *Goats/genetics
MH  - INDEL Mutation
MH  - *Myostatin/genetics
OTO - NOTNLM
OT  - IMWC goat
OT  - Myostatin (MSTN)
OT  - association
OT  - growth and differentiation factor 8 (GDF8)
OT  - growth trait
OT  - indel
EDAT- 2020/03/11 06:00
MHDA- 2021/12/28 06:00
CRDT- 2020/03/11 06:00
PHST- 2020/03/11 06:00 [pubmed]
PHST- 2021/12/28 06:00 [medline]
PHST- 2020/03/11 06:00 [entrez]
AID - 10.1080/10495398.2020.1736088 [doi]
PST - ppublish
SO  - Anim Biotechnol. 2021 Oct;32(5):610-615. doi: 10.1080/10495398.2020.1736088. Epub 
      2020 Mar 10.