PMID- 32153429
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 11
DP  - 2020
TI  - Numerical Simulation of the Influence of Geometric Configurations on Pressure 
      Difference in the Intraventricular Tunnel.
PG  - 133
LID - 10.3389/fphys.2020.00133 [doi]
LID - 133
AB  - OBJECTIVE: The geometric configuration of the intraventricular tunnel is related 
      to the re-intervention of left ventricular outflow tract stenosis after double 
      outlet right ventricle (DORV) correction. Hemodynamic simulation was performed in 
      order to study the influence of the geometric configuration of the IVT on the 
      pressure difference. METHODS: CT images of DORV were processed to reconstruct 3D 
      models of left and right ventricular flow chambers and aortic valve orifice, and 
      then the size and relative position of the aortic valve orifice and ventricular 
      septal defect were determined. Twenty five groups of the idealized models were 
      established according to orthogonal test design and computational fluid dynamics 
      method was applied to simulate hemodynamics. Three factors of geometric 
      configuration were considered for the study of their influences on the pressure 
      difference. The first factor is the distance between the ventricular septal 
      defect and the plane of the aortic valve (D(SA)), the second factor is the 
      ejection angle of blood from left ventricle flowing into the IVT (A(LT)), and the 
      third factor is the turning radius of the IVT (R(TT)). SPSS software was employed 
      to perform the orthogonal analysis. Additionally, twelve models with different 
      turning radii were established for hemodynamic analysis, with the turning radii 
      increasing from 0 mm with an interval of 1 mm, so as to study the influence of 
      turning radius on pressure difference of IVT. RESULTS: The analysis of variance 
      showed that only the change of R(TT) had a significant effect on the pressure 
      difference (P = 0 < 0.05), while the change of D(SA) and A(LT) had no significant 
      effect on the pressure difference (P = 0.459 > 0.05, P = 0.263 > 0.05). The 
      pressure difference decreases with the increase of R(TT). When R(TT) reaches 6 
      mm, the pressure difference gradually remains unchanged with the increase of 
      R(TT), and the rate of change is less than 5%. CONCLUSION: R(TT) in the IVT is 
      the main factor affecting the pressure difference. A small R(TT) will lead to a 
      large pressure difference in the IVT. When R(TT) increases to 6 mm, the pressure 
      difference in the IVT remains nearly unchanged. When performing the right 
      ventricular double outlet correction; the turning radius of the IVT should be 
      about 6 mm to ensure relatively small pressure difference.
CI  - Copyright (c) 2020 Yang, Wang, Qiao and Fan.
FAU - Yang, Yao
AU  - Yang Y
AD  - Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
FAU - Wang, Junjie
AU  - Wang J
AD  - College of Life Sciences and Bioengineering, Beijing University of Technology, 
      Beijing, China.
FAU - Qiao, Aike
AU  - Qiao A
AD  - College of Life Sciences and Bioengineering, Beijing University of Technology, 
      Beijing, China.
FAU - Fan, Xiangming
AU  - Fan X
AD  - College of Life Sciences and Bioengineering, Beijing University of Technology, 
      Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20200221
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
EIN - Front Physiol. 2020 Mar 20;11:256. PMID: 32265743
PMC - PMC7047733
OTO - NOTNLM
OT  - double outlet right ventricle
OT  - hemodynamics
OT  - intraventricular tunnel
OT  - numerical simulation
OT  - surgical planning
EDAT- 2020/03/11 06:00
MHDA- 2020/03/11 06:01
PMCR- 2020/02/21
CRDT- 2020/03/11 06:00
PHST- 2019/10/21 00:00 [received]
PHST- 2020/02/07 00:00 [accepted]
PHST- 2020/03/11 06:00 [entrez]
PHST- 2020/03/11 06:00 [pubmed]
PHST- 2020/03/11 06:01 [medline]
PHST- 2020/02/21 00:00 [pmc-release]
AID - 10.3389/fphys.2020.00133 [doi]
PST - epublish
SO  - Front Physiol. 2020 Feb 21;11:133. doi: 10.3389/fphys.2020.00133. eCollection 
      2020.