PMID- 32153440
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 11
DP  - 2020
TI  - Persistent Intrinsic Functional Network Connectivity Alterations in Middle-Aged 
      and Older Women With Remitted Depression.
PG  - 62
LID - 10.3389/fpsyt.2020.00062 [doi]
LID - 62
AB  - BACKGROUND: In younger adults, residual alterations in functional neural networks 
      persist during remitted depression. However, there are fewer data for midlife and 
      older adults at risk of recurrence. Such residual network alterations may 
      contribute to vulnerability to recurrence. This study examined intrinsic network 
      functional connectivity in midlife and older women with remitted depression. 
      METHODS: A total of 69 women (24 with a history of depression, 45 with no 
      psychiatric history) over 50 years of age completed 3T fMRI with resting-state 
      acquisition. Participants with remitted depression met DSM-IV-TR criteria for an 
      episode in the last 10 years but not the prior year. Whole-brain seed-to-voxel 
      resting-state functional connectivity analyses examined the default mode network 
      (DMN), executive control network (ECN), and salience network (SN), plus bilateral 
      hippocampal seeds. All analyses were adjusted for age and used cluster-level 
      correction for multiple comparisons with FDR < 0.05 and a height threshold of p < 
      0.001, uncorrected. RESULTS: Women with a history of depression exhibited 
      decreased functional connectivity between the SN (right insula seed) and ECN 
      regions, specifically the left superior frontal gyrus. They also exhibited 
      increased functional connectivity between the left hippocampus and the left 
      postcentral gyrus. We did not observe any group differences in functional 
      connectivity for DMN or ECN seeds. CONCLUSIONS: Remitted depression in women is 
      associated with connectivity differences between the SN and ECN and between the 
      hippocampus and the postcentral gyrus, a region involved in interoception. 
      Further work is needed to determine whether these findings are related to 
      functional alterations or are predictive of recurrence.
CI  - Copyright (c) 2020 Vega, Taylor, Gandelman, Boyd, Newhouse, Shokouhi and Albert.
FAU - Vega, Jennifer N
AU  - Vega JN
AD  - Center for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, 
      Vanderbilt University Medical Center, Nashville, TN, United States.
FAU - Taylor, Warren D
AU  - Taylor WD
AD  - Center for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, 
      Vanderbilt University Medical Center, Nashville, TN, United States.
AD  - Geriatric Research, Education, and Clinical Center, Veterans Affairs Tennessee 
      Valley Health System, Nashville, TN, United States.
FAU - Gandelman, Jason A
AU  - Gandelman JA
AD  - Vanderbilt University School of Medicine, Nashville, TN, United States.
FAU - Boyd, Brian D
AU  - Boyd BD
AD  - Center for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, 
      Vanderbilt University Medical Center, Nashville, TN, United States.
FAU - Newhouse, Paul A
AU  - Newhouse PA
AD  - Center for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, 
      Vanderbilt University Medical Center, Nashville, TN, United States.
AD  - Geriatric Research, Education, and Clinical Center, Veterans Affairs Tennessee 
      Valley Health System, Nashville, TN, United States.
FAU - Shokouhi, Sepideh
AU  - Shokouhi S
AD  - Center for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, 
      Vanderbilt University Medical Center, Nashville, TN, United States.
FAU - Albert, Kimberly M
AU  - Albert KM
AD  - Center for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, 
      Vanderbilt University Medical Center, Nashville, TN, United States.
LA  - eng
GR  - K24 MH110598/MH/NIMH NIH HHS/United States
GR  - R01 MH102246/MH/NIMH NIH HHS/United States
GR  - S10 OD021771/OD/NIH HHS/United States
GR  - T32 AG058524/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20200221
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC7047962
OTO - NOTNLM
OT  - executive control network (ECN)
OT  - remitted depression
OT  - resting state fMRI
OT  - salience network (SN)
OT  - women
EDAT- 2020/03/11 06:00
MHDA- 2020/03/11 06:01
PMCR- 2020/02/21
CRDT- 2020/03/11 06:00
PHST- 2019/07/29 00:00 [received]
PHST- 2020/01/24 00:00 [accepted]
PHST- 2020/03/11 06:00 [entrez]
PHST- 2020/03/11 06:00 [pubmed]
PHST- 2020/03/11 06:01 [medline]
PHST- 2020/02/21 00:00 [pmc-release]
AID - 10.3389/fpsyt.2020.00062 [doi]
PST - epublish
SO  - Front Psychiatry. 2020 Feb 21;11:62. doi: 10.3389/fpsyt.2020.00062. eCollection 
      2020.