PMID- 32154245
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 8
DP  - 2020
TI  - Allergen Immunotherapy-Induced Immunoglobulin G4 Reduces Basophil Activation in 
      House Dust Mite-Allergic Asthma Patients.
PG  - 30
LID - 10.3389/fcell.2020.00030 [doi]
LID - 30
AB  - It is unclear if allergen immunotherapy (AIT) can reduce allergy effector cell 
      activation. We evaluated the basophil response during Dermatophagoides 
      pteronyssinus (Der p) subcutaneous immunotherapy (SCIT) and its relationship to 
      allergen-specific immunoglobulin G4 (sIgG4) in allergic rhinitis and/or asthma 
      patients. The study included 55 subjects, of which 35 cases received Der p SCIT 
      and 20 controls received standard medications. Symptom and medication scores 
      (SMSs), sIgG4 levels, specific immunoglobulin E (sIgE) levels, allergen-induced 
      basophil activation tests (BATs) in whole blood, and BAT inhibition assays in 
      serum were determined at weeks 0, 4, 12, 16, 52, and 104 of SCIT. Levels of Der p 
      sIgG4 in SCIT patients significantly increased after 12 weeks of treatment 
      compared to week 0. Serum obtained from SCIT patients significantly inhibited 
      basophil activation after 12 weeks of treatment. Removal of immunoglobulin G4 
      (IgG4) antibodies at week 104 reduced the ability of serum to block basophil 
      activation. An increase of Der p sIgG4 rather than reduction of Der p sIgE 
      correlated with the reduction of basophil activation during SCIT. The sIgG4 
      antibodies may compete with sIgE binding to allergens to form an immunoglobulin E 
      (IgE)-allergen complex. SCIT reduced the sensitivity of allergen-triggered 
      basophil activation in Der p allergic rhinitis and/or asthma patients through 
      induction of sIgG4.
CI  - Copyright (c) 2020 Feng, Zeng, Su, Shi, Xian, Qin and Li.
FAU - Feng, Mulin
AU  - Feng M
AD  - Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory 
      Health, State Key Laboratory of Respiratory Disease, The First Affiliated 
      Hospital of Guangzhou Medical University, Guangzhou, China.
FAU - Zeng, Xiaohui
AU  - Zeng X
AD  - Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory 
      Health, State Key Laboratory of Respiratory Disease, The First Affiliated 
      Hospital of Guangzhou Medical University, Guangzhou, China.
FAU - Su, Qiujuan
AU  - Su Q
AD  - Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory 
      Health, State Key Laboratory of Respiratory Disease, The First Affiliated 
      Hospital of Guangzhou Medical University, Guangzhou, China.
FAU - Shi, Xu
AU  - Shi X
AD  - Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory 
      Health, State Key Laboratory of Respiratory Disease, The First Affiliated 
      Hospital of Guangzhou Medical University, Guangzhou, China.
FAU - Xian, Mo
AU  - Xian M
AD  - Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory 
      Health, State Key Laboratory of Respiratory Disease, The First Affiliated 
      Hospital of Guangzhou Medical University, Guangzhou, China.
FAU - Qin, Rundong
AU  - Qin R
AD  - Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory 
      Health, State Key Laboratory of Respiratory Disease, The First Affiliated 
      Hospital of Guangzhou Medical University, Guangzhou, China.
FAU - Li, Jing
AU  - Li J
AD  - Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory 
      Health, State Key Laboratory of Respiratory Disease, The First Affiliated 
      Hospital of Guangzhou Medical University, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20200220
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC7044416
OTO - NOTNLM
OT  - allergen immunotherapy
OT  - asthma
OT  - basophil activation test
OT  - rhinitis
OT  - serum specific immunoglobulin G4 (IgG4)
EDAT- 2020/03/11 06:00
MHDA- 2020/03/11 06:01
PMCR- 2020/01/01
CRDT- 2020/03/11 06:00
PHST- 2019/09/07 00:00 [received]
PHST- 2020/01/14 00:00 [accepted]
PHST- 2020/03/11 06:00 [entrez]
PHST- 2020/03/11 06:00 [pubmed]
PHST- 2020/03/11 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fcell.2020.00030 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2020 Feb 20;8:30. doi: 10.3389/fcell.2020.00030. eCollection 
      2020.