PMID- 32155721
OWN - NLM
STAT- MEDLINE
DCOM- 20201201
LR  - 20231113
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 5
DP  - 2020 Mar 6
TI  - Cell Fusion-Mediated Tissue Regeneration as an Inducer of Polyploidy and 
      Aneuploidy.
LID - 10.3390/ijms21051811 [doi]
LID - 1811
AB  - The biological phenomenon of cell fusion plays a crucial role in several 
      physiological processes, including wound healing and tissue regeneration. Here, 
      it is assumed that bone marrow-derived stem cells (BMSCs) could adopt the 
      specific properties of a different organ by cell fusion, thereby restoring organ 
      function. Cell fusion first results in the production of bi- or multinucleated 
      hybrid cells, which either remain as heterokaryons or undergo ploidy 
      reduction/heterokaryon-to-synkaryon transition (HST), thereby giving rise to 
      mononucleated daughter cells. This process is characterized by a merging of the 
      chromosomes from the previously discrete nuclei and their subsequent random 
      segregation into daughter cells. Due to extra centrosomes concomitant with 
      multipolar spindles, the ploidy reduction/HST could also be associated with 
      chromosome missegregation and, hence, induction of aneuploidy, genomic 
      instability, and even putative chromothripsis. However, while the majority of 
      such hybrids die or become senescent, aneuploidy and genomic instability appear 
      to be tolerated in hepatocytes, possibly for stress-related adaption processes. 
      Likewise, cell fusion-induced aneuploidy and genomic instability could also lead 
      to a malignant conversion of hybrid cells. This can occur during tissue 
      regeneration mediated by BMSC fusion in chronically inflamed tissue, which is a 
      cell fusion-friendly environment, but is also enriched for mutagenic reactive 
      oxygen and nitrogen species.
FAU - Dornen, Jessica
AU  - Dornen J
AD  - Institute of Immunology, Center for Biomedical Education and Research (ZBAF), 
      Witten/Herdecke University, 58448 Witten, Germany.
FAU - Sieler, Mareike
AU  - Sieler M
AD  - Institute of Immunology, Center for Biomedical Education and Research (ZBAF), 
      Witten/Herdecke University, 58448 Witten, Germany.
FAU - Weiler, Julian
AU  - Weiler J
AD  - Institute of Immunology, Center for Biomedical Education and Research (ZBAF), 
      Witten/Herdecke University, 58448 Witten, Germany.
FAU - Keil, Silvia
AU  - Keil S
AD  - Institute of Immunology, Center for Biomedical Education and Research (ZBAF), 
      Witten/Herdecke University, 58448 Witten, Germany.
FAU - Dittmar, Thomas
AU  - Dittmar T
AUID- ORCID: 0000-0001-8505-3424
AD  - Institute of Immunology, Center for Biomedical Education and Research (ZBAF), 
      Witten/Herdecke University, 58448 Witten, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200306
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - *Aneuploidy
MH  - Animals
MH  - *Cell Fusion
MH  - *Chromosomal Instability
MH  - Humans
MH  - Hybrid Cells
MH  - *Polyploidy
MH  - *Regeneration
PMC - PMC7084716
OTO - NOTNLM
OT  - aneuploidy
OT  - cell fusion
OT  - polyploidy
OT  - stem cells
OT  - tissue regeneration
COIS- The authors declare no conflicts of interest.
EDAT- 2020/03/12 06:00
MHDA- 2020/12/02 06:00
PMCR- 2020/03/01
CRDT- 2020/03/12 06:00
PHST- 2020/01/29 00:00 [received]
PHST- 2020/02/28 00:00 [revised]
PHST- 2020/03/04 00:00 [accepted]
PHST- 2020/03/12 06:00 [entrez]
PHST- 2020/03/12 06:00 [pubmed]
PHST- 2020/12/02 06:00 [medline]
PHST- 2020/03/01 00:00 [pmc-release]
AID - ijms21051811 [pii]
AID - ijms-21-01811 [pii]
AID - 10.3390/ijms21051811 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Mar 6;21(5):1811. doi: 10.3390/ijms21051811.