PMID- 32155778
OWN - NLM
STAT- MEDLINE
DCOM- 20210318
LR  - 20240328
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 10
IP  - 3
DP  - 2020 Mar 6
TI  - A Preliminary Study of Cu Exposure Effects upon Alzheimer's Amyloid Pathology.
LID - 10.3390/biom10030408 [doi]
LID - 408
AB  - A large body of evidence indicates that dysregulation of cerebral biometals (Fe, 
      Cu, Zn) and their interactions with amyloid precursor protein (APP) and Abeta 
      amyloid may contribute to the Alzheimer's disease (AD) Abeta amyloid pathology. 
      However, the molecular underpinnings associated with the interactions are still 
      not fully understood. Herein we have further validated the exacerbation of Abeta 
      oligomerization by Cu and H(2)O(2) in vitro. We have also reported that Cu 
      enhanced APP translations via its 5' untranslated region (5'UTR) of mRNA in 
      SH-SY5Y cells, and increased Abeta amyloidosis and expression of associated 
      pro-inflammatory cytokines such as MCP-5 in Alzheimer's APP/PS1 doubly transgenic 
      mice. This preliminary study may further unravel the pathogenic role of Cu in 
      Alzheimer's Abeta amyloid pathogenesis, warranting further investigation.
FAU - Pilozzi, Alexander
AU  - Pilozzi A
AD  - Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General 
      Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
FAU - Yu, Zhanyang
AU  - Yu Z
AUID- ORCID: 0000-0003-3787-8127
AD  - Neuroprotection Research Laboratory, Departments of Radiology and Neurology, 
      Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, 
      USA.
FAU - Carreras, Isabel
AU  - Carreras I
AD  - Department of Veterans Affairs, VA Medical Center, Bedford, MA 01730, USA.
AD  - Department of Neurology, Boston University School of Medicine, Boston, MA 02118, 
      USA.
FAU - Cormier, Kerry
AU  - Cormier K
AD  - Department of Veterans Affairs, VA Medical Center, Bedford, MA 01730, USA.
AD  - Department of Neurology, Boston University School of Medicine, Boston, MA 02118, 
      USA.
FAU - Hartley, Dean
AU  - Hartley D
AD  - Autism Speaks, Chicago, IL 60659, USA.
FAU - Rogers, Jack
AU  - Rogers J
AD  - Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General 
      Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
FAU - Dedeoglu, Alpaslan
AU  - Dedeoglu A
AD  - Department of Veterans Affairs, VA Medical Center, Bedford, MA 01730, USA.
AD  - Department of Neurology, Boston University School of Medicine, Boston, MA 02118, 
      USA.
FAU - Huang, Xudong
AU  - Huang X
AUID- ORCID: 0000-0002-4811-1901
AD  - Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General 
      Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
LA  - eng
GR  - R01 AG056614/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20200306
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - 0 (APP protein, human)
RN  - 0 (APP protein, mouse)
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 789U1901C5 (Copper)
SB  - IM
MH  - *Alzheimer Disease/genetics/metabolism/pathology
MH  - *Amyloid beta-Peptides/chemistry/genetics/metabolism
MH  - *Amyloid beta-Protein Precursor/biosynthesis/chemistry/genetics
MH  - Animals
MH  - Cell Line, Tumor
MH  - Copper/*toxicity
MH  - Female
MH  - Humans
MH  - Mice
MH  - Mice, Transgenic
MH  - *Protein Biosynthesis
MH  - Protein Multimerization/*drug effects
PMC - PMC7175127
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Abeta amyloid
OT  - amyloid precursor protein
OT  - copper
OT  - cytokine
OT  - neuroinflammation
COIS- The authors declare no conflict of interest.
EDAT- 2020/03/12 06:00
MHDA- 2021/03/19 06:00
PMCR- 2020/03/01
CRDT- 2020/03/12 06:00
PHST- 2020/02/13 00:00 [received]
PHST- 2020/03/02 00:00 [revised]
PHST- 2020/03/04 00:00 [accepted]
PHST- 2020/03/12 06:00 [entrez]
PHST- 2020/03/12 06:00 [pubmed]
PHST- 2021/03/19 06:00 [medline]
PHST- 2020/03/01 00:00 [pmc-release]
AID - biom10030408 [pii]
AID - biomolecules-10-00408 [pii]
AID - 10.3390/biom10030408 [doi]
PST - epublish
SO  - Biomolecules. 2020 Mar 6;10(3):408. doi: 10.3390/biom10030408.