PMID- 32156131
OWN - NLM
STAT- MEDLINE
DCOM- 20210111
LR  - 20210111
IS  - 2224-5839 (Electronic)
IS  - 2224-5820 (Linking)
VI  - 9
IP  - 2
DP  - 2020 Mar
TI  - The efficacy of vitamin D therapy for patients with COPD: a meta-analysis of 
      randomized controlled trials.
PG  - 286-297
LID - 10.21037/apm.2020.02.26 [doi]
AB  - BACKGROUND: Many studies have demonstrated that vitamin D has clinical benefits 
      when used to treat patients with chronic obstructive pulmonary disease (COPD). 
      However, most of these studies have insufficient samples or inconsistent results. 
      The aim of this meta-analysis was to evaluate the effects of vitamin D therapy in 
      patients with COPD. METHODS: We performed an electronic literature search of the 
      databases PubMed, China National Knowledge Internet (CNKI), Embase, Web of 
      Science and Wanfang Data. Meta-analysis was carried out by Review Manager Version 
      5.3 (Revman 5.3), and standardized mean difference (SMD) and mean difference (MD) 
      were used to assess the efficacy of vitamin D therapy in patients with COPD. 
      RESULTS: A total of 25 articles involving 2,670 participants were included in 
      this study. The overall results showed a statistical significance of vitamin D 
      therapy in patients with COPD on forced expiratory volume in 1 second (FEV1) 
      (SMD: 1.21, 95% CI: 0.76-1.66, P<0.01), FEV1/FVC (SMD: 1.07, 95% CI: 0.56-1.58, 
      P<0.01), Exacerbations (SMD: 0.39, 95% CI: 0.23-0.64, P<0.01), Sputum volume 
      (SMD: -6.02, 95% CI: -8.25 to 3.79, P<0.01), 6-minute walk distance (6MWD) (MD: 
      8.82, 95% CI: 1.67-15.98, P=0.02) and COPD assessment test (CAT) score (SMD: 
      -1.19, 95% CI: -1.74 to 0.63, P<0.01). CONCLUSIONS: Our analysis indicated that 
      vitamin D used in patients with COPD could improve the lung function (FEV1, 
      FEV1/FVC), 6MWD and reduce acute exacerbation, sputum volume and CAT score.
FAU - Li, Xiaoyan
AU  - Li X
AD  - Department of Respiratory and Critical Care Medicine, The First Affiliated 
      Hospital of Chengdu Medical College, Chengdu 610500, China.
FAU - He, Jie
AU  - He J
AD  - Department of Respiratory and Critical Care Medicine, The First Affiliated 
      Hospital of Chengdu Medical College, Chengdu 610500, China. 13540246974@163.com.
FAU - Yu, Mi
AU  - Yu M
AD  - Department of Respiratory and Critical Care Medicine, The First Affiliated 
      Hospital of Chengdu Medical College, Chengdu 610500, China.
FAU - Sun, Jian
AU  - Sun J
AD  - Department of Respiratory and Critical Care Medicine, The First Affiliated 
      Hospital of Chengdu Medical College, Chengdu 610500, China. 157110097@qq.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20200305
PL  - China
TA  - Ann Palliat Med
JT  - Annals of palliative medicine
JID - 101585484
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - China
MH  - *Dietary Supplements
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/*drug therapy
MH  - Randomized Controlled Trials as Topic
MH  - Vitamin D/*therapeutic use
OTO - NOTNLM
OT  - Chronic obstructive pulmonary disease (COPD)
OT  - meta-analysis
OT  - vitamin D
EDAT- 2020/03/12 06:00
MHDA- 2021/01/12 06:00
CRDT- 2020/03/12 06:00
PHST- 2019/12/06 00:00 [received]
PHST- 2020/02/04 00:00 [accepted]
PHST- 2020/03/12 06:00 [pubmed]
PHST- 2021/01/12 06:00 [medline]
PHST- 2020/03/12 06:00 [entrez]
AID - apm.2020.02.26 [pii]
AID - 10.21037/apm.2020.02.26 [doi]
PST - ppublish
SO  - Ann Palliat Med. 2020 Mar;9(2):286-297. doi: 10.21037/apm.2020.02.26. Epub 2020 
      Mar 5.