PMID- 32156548
OWN - NLM
STAT- MEDLINE
DCOM- 20200527
LR  - 20200527
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 249
DP  - 2020 May 15
TI  - CXCL12/CXCR4 axis in the microenvironment of solid tumors: A critical mediator of 
      metastasis.
PG  - 117534
LID - S0024-3205(20)30282-4 [pii]
LID - 10.1016/j.lfs.2020.117534 [doi]
AB  - Tumors are dynamic tissue masses, so requiring continuous exposure to the host 
      cells, nurturing them into pave a path for tumor growth and metastasis. C-X-C 
      chemokine ligand 12 (CXCL12)/C-X-C chemokine receptor type 4 (CXCR4) is the key 
      signaling for such aim. Gathering knowledge about the activity within this axis 
      would deepen our insight into the utmost importance this signaling taken to 
      attract and cross-connect multiple cells within the tumor microenvironment (TME) 
      aiming for tumor progression and metastasis. The concept behind this review is to 
      underscore the multi-tasking roles taken by CXCL12/CXCR4 signaling in tumor 
      metastasis, and to also suggest some strategies to target the activities within 
      this axis.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Mortezaee, Keywan
AU  - Mortezaee K
AD  - Department of Anatomy, School of Medicine, Kurdistan University of Medical 
      Sciences, Sanandaj, Iran. Electronic address: Keywan987@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200307
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (CXCL12 protein, human)
RN  - 0 (CXCR4 protein, human)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Receptors, CXCR4)
SB  - IM
MH  - Chemokine CXCL12/*metabolism
MH  - Humans
MH  - *Neoplasm Metastasis
MH  - Neoplasms/metabolism/*pathology
MH  - Receptors, CXCR4/*metabolism
MH  - Signal Transduction
MH  - *Tumor Microenvironment
OTO - NOTNLM
OT  - C-X-C chemokine ligand 12 (CXCL12)
OT  - CXCR4
OT  - Cancer cell
OT  - Cancer stem cell (CSC)
OT  - Hypoxia
OT  - Tumor microenvironment (TME)
COIS- Declaration of competing interest Not applicable. The manuscript was written only 
      by one author.
EDAT- 2020/03/12 06:00
MHDA- 2020/05/28 06:00
CRDT- 2020/03/12 06:00
PHST- 2019/12/24 00:00 [received]
PHST- 2020/02/24 00:00 [revised]
PHST- 2020/03/05 00:00 [accepted]
PHST- 2020/03/12 06:00 [pubmed]
PHST- 2020/05/28 06:00 [medline]
PHST- 2020/03/12 06:00 [entrez]
AID - S0024-3205(20)30282-4 [pii]
AID - 10.1016/j.lfs.2020.117534 [doi]
PST - ppublish
SO  - Life Sci. 2020 May 15;249:117534. doi: 10.1016/j.lfs.2020.117534. Epub 2020 Mar 
      7.