PMID- 32156841
OWN - NLM
STAT- MEDLINE
DCOM- 20210125
LR  - 20210125
IS  - 1735-8604 (Electronic)
IS  - 1735-8582 (Linking)
VI  - 14
IP  - 1
DP  - 2020 Jan
TI  - Factors Associated With Short-Term and Long-Term Survival in Patients Undergoing 
      Hemodialysis Using Semi- Parametric Mixture Cure Models.
PG  - 44-51
AB  - INTRODUCTION: Understanding the factors affecting the survival of patients 
      undergoing hemodialysis is the mainstay of care in this population. The present 
      study aims at finding these features using novel cure models that discover 
      factors important in both long term and short-term survival of patients 
      undergoing HD. METHODS: Data were retrospectively collected from the database of 
      Shiraz University of Medical Sciences Special Diseases Administration including 
      patients of 34 HD centers during 2011 to 2015. The primary outcome was death. 
      Considering people with no death event as cured, the rest of the patients 
      considered as uncured. To evaluate the factors affecting mortality, we used a 
      mixture cure model (MCM) that model the long-term and short-term survival of 
      patients separately. RESULTS: Of 506 patients, 68.75% of women and 75.0% of men 
      were long-term survivors. The mean (+/- SD) age of the patients was 57.5 (+/- 16.5) 
      years and the empirical value of the cure rate was 72.9%. Sex, age, and Kt/Vurea 
      were recognized as important factors in the long-term survival. In other words, 
      lower age, male sex, and Kt/ Vurea >/= 1.2 significantly increased the odds of 
      being cured. The factors effective in short-term survival were mean corpuscular 
      hemoglobin concentration (MCHC) and serum hemoglobin. The serum hemoglobin 
      between 11 and 12.5 and a high MCHC decreased the risk of death. CONCLUSION: 
      Using cure model survival analysis, it was found that factors affecting the 
      proportion of the patients with long-term survival might be different from those 
      affecting short-term survival.
FAU - Shayan, Zahra
AU  - Shayan Z
FAU - Ebrahimi, Vahid
AU  - Ebrahimi V
FAU - Ezzatzadegan Jahromi, Shahrokh
AU  - Ezzatzadegan Jahromi S
AD  - Shiraz University of Medical Sciences, Shiraz, Iran. shjahromi@sums.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - Iran
TA  - Iran J Kidney Dis
JT  - Iranian journal of kidney diseases
JID - 101316967
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Iran/epidemiology
MH  - Male
MH  - Middle Aged
MH  - *Models, Statistical
MH  - Renal Dialysis/*mortality
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Survival Rate
EDAT- 2020/03/12 06:00
MHDA- 2021/01/26 06:00
CRDT- 2020/03/12 06:00
PHST- 2019/03/09 00:00 [received]
PHST- 2019/06/24 00:00 [accepted]
PHST- 2020/03/12 06:00 [entrez]
PHST- 2020/03/12 06:00 [pubmed]
PHST- 2021/01/26 06:00 [medline]
AID - 4688/1124 [pii]
PST - ppublish
SO  - Iran J Kidney Dis. 2020 Jan;14(1):44-51.