PMID- 32158749
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231103
IS  - 2296-4185 (Print)
IS  - 2296-4185 (Electronic)
IS  - 2296-4185 (Linking)
VI  - 8
DP  - 2020
TI  - Nanoscale Self-Assembly for Therapeutic Delivery.
PG  - 127
LID - 10.3389/fbioe.2020.00127 [doi]
LID - 127
AB  - Self-assembly is the process of association of individual units of a material 
      into highly arranged/ordered structures/patterns. It imparts unique properties to 
      both inorganic and organic structures, so generated, via non-covalent 
      interactions. Currently, self-assembled nanomaterials are finding a wide variety 
      of applications in the area of nanotechnology, imaging techniques, biosensors, 
      biomedical sciences, etc., due to its simplicity, spontaneity, scalability, 
      versatility, and inexpensiveness. Self-assembly of amphiphiles into 
      nanostructures (micelles, vesicles, and hydrogels) happens due to various 
      physical interactions. Recent advancements in the area of drug delivery have 
      opened up newer avenues to develop novel drug delivery systems (DDSs) and 
      self-assembled nanostructures have shown their tremendous potential to be used as 
      facile and efficient materials for this purpose. The main objective of the 
      projected review is to provide readers a concise and straightforward knowledge of 
      basic concepts of supramolecular self-assembly process and how these highly 
      functionalized and efficient nanomaterials can be useful in biomedical 
      applications. Approaches for the self-assembly have been discussed for the 
      fabrication of nanostructures. Advantages and limitations of these systems along 
      with the parameters that are to be taken into consideration while designing a 
      therapeutic delivery vehicle have also been outlined. In this review, various 
      macro- and small-molecule-based systems have been elaborated. Besides, a section 
      on DNA nanostructures as intelligent materials for future applications is also 
      included.
CI  - Copyright (c) 2020 Yadav, Sharma and Kumar.
FAU - Yadav, Santosh
AU  - Yadav S
AD  - Nucleic Acids Research Laboratory, CSIR Institute of Genomics and Integrative 
      Biology, Delhi, India.
FAU - Sharma, Ashwani Kumar
AU  - Sharma AK
AD  - Nucleic Acids Research Laboratory, CSIR Institute of Genomics and Integrative 
      Biology, Delhi, India.
FAU - Kumar, Pradeep
AU  - Kumar P
AD  - Nucleic Acids Research Laboratory, CSIR Institute of Genomics and Integrative 
      Biology, Delhi, India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200225
PL  - Switzerland
TA  - Front Bioeng Biotechnol
JT  - Frontiers in bioengineering and biotechnology
JID - 101632513
PMC - PMC7051917
OTO - NOTNLM
OT  - amphiphilicity
OT  - drug delivery
OT  - nanostructures
OT  - polymers
OT  - self-assembly
OT  - small molecules
EDAT- 2020/03/12 06:00
MHDA- 2020/03/12 06:01
PMCR- 2020/01/01
CRDT- 2020/03/12 06:00
PHST- 2019/09/27 00:00 [received]
PHST- 2020/02/10 00:00 [accepted]
PHST- 2020/03/12 06:00 [entrez]
PHST- 2020/03/12 06:00 [pubmed]
PHST- 2020/03/12 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fbioe.2020.00127 [doi]
PST - epublish
SO  - Front Bioeng Biotechnol. 2020 Feb 25;8:127. doi: 10.3389/fbioe.2020.00127. 
      eCollection 2020.