PMID- 32159926
OWN - NLM
STAT- MEDLINE
DCOM- 20210520
LR  - 20210520
IS  - 1474-9726 (Electronic)
IS  - 1474-9718 (Print)
IS  - 1474-9718 (Linking)
VI  - 19
IP  - 4
DP  - 2020 Apr
TI  - Reduced caloric intake and periodic fasting independently contribute to metabolic 
      effects of caloric restriction.
PG  - e13138
LID - 10.1111/acel.13138 [doi]
LID - e13138
AB  - Caloric restriction (CR) has positive effects on health and longevity. CR in 
      mammals implements time-restricted (TR) feeding, a short period of feeding 
      followed by prolonged fasting. Periodic fasting, in the form of TR or mealtime, 
      improves metabolism without reduction in caloric intake. In order to understand 
      the relative contribution of reduced food intake and periodic fasting to the 
      health benefits of CR, we compared physiological and metabolic changes induced by 
      CR and TR (without reduced food intake) in mice. CR significantly reduced blood 
      glucose and insulin around the clock, improved glucose tolerance, and increased 
      insulin sensitivity (IS). TR reduced blood insulin and increased insulin 
      sensitivity, but in contrast to CR, TR did not improve glucose homeostasis. Liver 
      expression of circadian clock genes was affected by both diets while the mRNA 
      expression of glucose metabolism genes was significantly induced by CR, and not 
      by TR, which is in agreement with the minor effect of TR on glucose metabolism. 
      Thus, periodic fasting contributes to some metabolic benefits of CR, but TR is 
      metabolically different from CR. This difference might contribute to differential 
      effects of CR and TR on longevity.
CI  - (c) 2020 The Authors. Aging Cell published by the Anatomical Society and John Wiley 
      & Sons Ltd.
FAU - Velingkaar, Nikkhil
AU  - Velingkaar N
AD  - Department of Biological, Geological, and Environmental Sciences and Center for 
      Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, 
      USA.
FAU - Mezhnina, Volha
AU  - Mezhnina V
AD  - Department of Biological, Geological, and Environmental Sciences and Center for 
      Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, 
      USA.
AD  - Institute of Genetics and Cytology, National Academy of Science of Belarus, 
      Minsk, Belarus.
FAU - Poe, Allan
AU  - Poe A
AD  - Department of Biological, Geological, and Environmental Sciences and Center for 
      Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, 
      USA.
FAU - Makwana, Kuldeep
AU  - Makwana K
AD  - Department of Biological, Geological, and Environmental Sciences and Center for 
      Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, 
      USA.
FAU - Tulsian, Richa
AU  - Tulsian R
AD  - Department of Biological, Geological, and Environmental Sciences and Center for 
      Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, 
      USA.
FAU - Kondratov, Roman V
AU  - Kondratov RV
AUID- ORCID: 0000-0003-3449-745X
AD  - Department of Biological, Geological, and Environmental Sciences and Center for 
      Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, 
      USA.
LA  - eng
GR  - R01 AG039547/AG/NIA NIH HHS/United States
GR  - S10 OD025252/OD/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20200311
PL  - England
TA  - Aging Cell
JT  - Aging cell
JID - 101130839
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
CIN - Aging (Albany NY). 2020 Dec 13;12(23):23422-23424. PMID: 33318315
MH  - Animals
MH  - Blood Glucose/analysis/*metabolism
MH  - *Caloric Restriction
MH  - *Energy Intake
MH  - *Fasting
MH  - Glucose Tolerance Test
MH  - Insulin/blood/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
PMC - PMC7189989
OTO - NOTNLM
OT  - caloric restriction
OT  - circadian rhythms
OT  - fasting
OT  - gene expression
OT  - glucose homeostasis
OT  - insulin sensitivity
OT  - longevity
OT  - metabolism
COIS- The authors declare no competing interests.
EDAT- 2020/03/12 06:00
MHDA- 2021/05/21 06:00
PMCR- 2020/04/01
CRDT- 2020/03/12 06:00
PHST- 2019/09/24 00:00 [received]
PHST- 2020/02/01 00:00 [revised]
PHST- 2020/02/23 00:00 [accepted]
PHST- 2020/03/12 06:00 [pubmed]
PHST- 2021/05/21 06:00 [medline]
PHST- 2020/03/12 06:00 [entrez]
PHST- 2020/04/01 00:00 [pmc-release]
AID - ACEL13138 [pii]
AID - 10.1111/acel.13138 [doi]
PST - ppublish
SO  - Aging Cell. 2020 Apr;19(4):e13138. doi: 10.1111/acel.13138. Epub 2020 Mar 11.