PMID- 32160746
OWN - NLM
STAT- MEDLINE
DCOM- 20200715
LR  - 20200715
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 54
IP  - 9
DP  - 2020 May 5
TI  - Nontarget and Target Screening of Organohalogen Compounds in Mussels and Sediment 
      from Hiroshima Bay, Japan: Occurrence of Novel Bioaccumulative Substances.
PG  - 5480-5488
LID - 10.1021/acs.est.9b06998 [doi]
AB  - Recent screening surveys have shown the presence of unknown halogenated compounds 
      in the marine environment at comparable levels to persistent organic pollutants 
      (POPs). However, their exposure levels and profiles in marine organisms and 
      bioaccumulative potentials remain unclear. The present study performed 
      nontarget/target screening of organohalogen compounds (OHCs) in mussel and 
      sediment samples collected from Hiroshima Bay, Japan, in 2012 and 2018 by using 
      integrated analyses of two-dimensional gas chromatography-high resolution 
      time-of-flight mass spectrometry (GCxGC-HRToFMS) and magnetic sector GC-HRMS. 
      Nontarget analysis by GCxGC-HRToFMS revealed the detection of approximately 60 
      OHCs including unknown mixed halogenated compounds (UHC-Br(3-5)Cl) with molecular 
      formulae of C(9)H(6)Br(3)ClO, C(9)H(5)Br(4)ClO, and C(9)H(4)Br(5)ClO in the 
      mussel. Interestingly, UHC-Br(3-5)Cl concentrations in the mussel samples, which 
      were semi-quantified by GC-HRMS, were comparable to or higher than those of POPs 
      at all the locations surveyed, and their geographical distribution patterns 
      differed from those of other OHCs. These results suggest that UHC-Br(3-5)Cl are 
      ubiquitous in coastal waters of Hiroshima Bay and derived from a specific 
      source(s). The biota-sediment accumulation factors (BSAFs) of UHC-Br(3-5)Cl, 
      estimated for a paired sample set of mussel (ng/g lw) and sediment (ng/g TOC), 
      were 1 order of magnitude higher than those for POPs with similar log K(ow) 
      values, indicating their high bioaccumulative potential.
FAU - Goto, Akitoshi
AU  - Goto A
AD  - Center for Marine Environmental Studies (CMES), Ehime University, 2-5 Bunkyo-cho, 
      Matsuyama, Ehime 790-8577, Japan.
FAU - Tue, Nguyen Minh
AU  - Tue NM
AUID- ORCID: 0000-0002-6197-6731
AD  - Center for Marine Environmental Studies (CMES), Ehime University, 2-5 Bunkyo-cho, 
      Matsuyama, Ehime 790-8577, Japan.
FAU - Isobe, Tomohiko
AU  - Isobe T
AD  - Center for Health and Environmental Risk Research, National Institute for 
      Environmental Studies (NIES), 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan.
FAU - Takahashi, Shin
AU  - Takahashi S
AD  - Center for Marine Environmental Studies (CMES), Ehime University, 2-5 Bunkyo-cho, 
      Matsuyama, Ehime 790-8577, Japan.
AD  - Center of Advanced Technology for the Environment, Agricultural Faculty, Ehime 
      University, 3-5-7 Tarumi, Matsuyama, Ehime 790-8566, Japan.
FAU - Tanabe, Shinsuke
AU  - Tanabe S
AD  - Center for Marine Environmental Studies (CMES), Ehime University, 2-5 Bunkyo-cho, 
      Matsuyama, Ehime 790-8577, Japan.
FAU - Kunisue, Tatsuya
AU  - Kunisue T
AUID- ORCID: 0000-0002-8167-1564
AD  - Center for Marine Environmental Studies (CMES), Ehime University, 2-5 Bunkyo-cho, 
      Matsuyama, Ehime 790-8577, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200323
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Environmental Pollutants)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Animals
MH  - Bays
MH  - *Bivalvia
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*analysis
MH  - Gas Chromatography-Mass Spectrometry
MH  - Japan
MH  - Water Pollutants, Chemical/*analysis
EDAT- 2020/03/13 06:00
MHDA- 2020/07/16 06:00
CRDT- 2020/03/13 06:00
PHST- 2020/03/13 06:00 [pubmed]
PHST- 2020/07/16 06:00 [medline]
PHST- 2020/03/13 06:00 [entrez]
AID - 10.1021/acs.est.9b06998 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2020 May 5;54(9):5480-5488. doi: 10.1021/acs.est.9b06998. 
      Epub 2020 Mar 23.