PMID- 32162578
OWN - NLM
STAT- MEDLINE
DCOM- 20210924
LR  - 20210924
IS  - 1477-0970 (Electronic)
IS  - 1352-4585 (Linking)
VI  - 26
IP  - 11
DP  - 2020 Oct
TI  - Moving exercise research in multiple sclerosis forward (the MoXFo initiative): 
      Developing consensus statements for research.
PG  - 1303-1308
LID - 10.1177/1352458520910360 [doi]
AB  - Exercise as a subset of physical activity is a cornerstone in the management of 
      multiple sclerosis (MS) based on its pleotropic effects. There is an exponential 
      increase in the quantity of research on exercise in MS, yet a number of barriers 
      associated with study content and quality hamper rapid progress in the field. To 
      address these barriers and accelerate discovery, a new international partnership 
      of MS-related experts in exercise has emerged with the goal of advancing the 
      research agenda. As a first step, the expert panel met in May 2018 and identified 
      the most urgent areas for moving the field forward, and discussed the framework 
      for such a process. This led to identification of five themes, namely 
      "Definitions and terminology," "Study methodology," "Reporting and outcomes," 
      "Adherence to exercise," and "Mechanisms of action." Based on the identified 
      themes, five expert groups have been formed, that will further (a) outline the 
      challenges per theme and (b) provide recommendations for moving forward. We aim 
      to involve and collaborate with people with MS/MS organizations (e.g. Multiple 
      Sclerosis International Federation (MSIF) and European Multiple Sclerosis 
      Platform (EMSP)) in all of these five themes. The generation of this thematic 
      framework with multi-expert perspectives can bolster the quality and scope of 
      exercise studies in MS that may ultimately improve the daily lives of people with 
      MS.
FAU - Dalgas, Ulrik
AU  - Dalgas U
AD  - Section for Sport Science, Department of Public Health, Aarhus University, 
      Aarhus, Denmark.
FAU - Hvid, Lars G
AU  - Hvid LG
AUID- ORCID: 0000-0003-3233-0429
AD  - Section for Sport Science, Department of Public Health, Aarhus University, 
      Aarhus, Denmark.
FAU - Kwakkel, Gert
AU  - Kwakkel G
AD  - Department of Rehabilitation Medicine, Amsterdam Movement Sciences, Amsterdam 
      Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The 
      Netherlands/Department of Physical Therapy and Human Movement Sciences, Feinberg 
      School of Medicine, Northwestern University, Chicago, IL, USA/Department of 
      Neurorehabilitation, Amsterdam Rehabilitation Research Centre, Reade, Amsterdam, 
      The Netherlands.
FAU - Motl, Robert W
AU  - Motl RW
AUID- ORCID: 0000-0002-5894-2290
AD  - Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, 
      AL, USA.
FAU - de Groot, Vincent
AU  - de Groot V
AD  - Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, 
      The Netherlands/MS Center Amsterdam, VU University Medical Center, Amsterdam, The 
      Netherlands/Amsterdam Public Health Research Institute, VU University Medical 
      Center, Amsterdam, The Netherlands.
FAU - Feys, Peter
AU  - Feys P
AUID- ORCID: 0000-0002-5680-5495
AD  - REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt 
      University, Diepenbeek, Belgium.
FAU - Op't Eijnde, Bert
AU  - Op't Eijnde B
AD  - REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt 
      University, Diepenbeek, Belgium.
FAU - Coote, Susan
AU  - Coote S
AD  - School of Allied Health, Faculty of Education and Health Sciences, University of 
      Limerick, Limerick, Ireland.
FAU - Beckerman, Heleen
AU  - Beckerman H
AD  - Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, 
      The Netherlands/MS Center Amsterdam, VU University Medical Center, Amsterdam, The 
      Netherlands/Amsterdam Public Health Research Institute, VU University Medical 
      Center, Amsterdam, The Netherlands.
FAU - Pfeifer, Klaus
AU  - Pfeifer K
AD  - Division of Exercise and Health, Department of Sport Science, Friedrich-Alexander 
      University Erlangen-Nurnberg (FAU), Erlangen, Germany.
FAU - Streber, Rene
AU  - Streber R
AD  - Division of Exercise and Health, Department of Sport Science, Friedrich-Alexander 
      University Erlangen-Nurnberg (FAU), Erlangen, Germany; Deutscher Verband fur 
      Gesundheitssport und Sporttherapie e.V. (DVGS), Hurth, Germany.
FAU - Peters, Stefan
AU  - Peters S
AD  - Deutscher Verband fur Gesundheitssport und Sporttherapie e.V. (DVGS), Hurth, 
      Germany.
FAU - Riemann-Lorenz, Karin
AU  - Riemann-Lorenz K
AD  - Institut fur Neuroimmunologie und Multiple Sklerose, Universitatsklinikum 
      Hamburg-Eppendorf, Hamburg, Germany.
FAU - Rosenkranz, Sina Catherine
AU  - Rosenkranz SC
AD  - Institut fur Neuroimmunologie und Multiple Sklerose, Universitatsklinikum 
      Hamburg-Eppendorf, Hamburg, Germany/Klinik und Poliklinik fur Neurologie, 
      Universitatsklinikum Hamburg-Eppendorf, Hamburg, Germany.
FAU - Centonze, Diego
AU  - Centonze D
AD  - Unit of Neurology, IRCCS Neuromed, Pozzilli, Italy.
FAU - Van Asch, Paul
AU  - Van Asch P
AD  - Fit Up Physiotherapy Centre, Kontich, Belgium.
FAU - Bansi, Jens
AU  - Bansi J
AD  - Deparment of Neurology, Kliniken-Valens, Rehabilitationsklinik-Valens, Valens, 
      Switzerland.
FAU - Sandroff, Brian M
AU  - Sandroff BM
AUID- ORCID: 0000-0002-2013-7632
AD  - Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, 
      AL, USA.
FAU - Pilutti, Lara A
AU  - Pilutti LA
AD  - Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, ON, 
      Canada.
FAU - Ploughman, Michelle
AU  - Ploughman M
AUID- ORCID: 0000-0002-4594-0077
AD  - Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
FAU - Freeman, Jennifer
AU  - Freeman J
AD  - Faculty of Health: Medicine, Dentistry and Human Sciences, University of 
      Plymouth, Plymouth, UK.
FAU - Paul, Lorna
AU  - Paul L
AUID- ORCID: 0000-0003-2869-0309
AD  - School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK.
FAU - Dawes, Helen
AU  - Dawes H
AD  - Movement Science Group, School of Life Sciences, Oxford Brookes University, 
      Oxford, UK.
FAU - Romberg, Anders
AU  - Romberg A
AD  - Masku Neurological Rehabilitation Centre, Masku, Finland.
FAU - Kalron, Alon
AU  - Kalron A
AD  - Department of Physical Therapy, The Stanley Steyer School of Health Professions, 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel/Sagol School 
      of Neurosciences, Tel-Aviv University, Tel Aviv, Israel.
FAU - Stellmann, Jan-Patrick
AU  - Stellmann JP
AD  - APHM, Hopital de la Timone, CEMEREM, Marseille, France/Aix-Marseille University, 
      CNRS, CRMBM, UMR 7339, Marseille, France.
FAU - Friese, Manuel A
AU  - Friese MA
AUID- ORCID: 0000-0001-6380-2420
AD  - Institut fur Neuroimmunologie und Multiple Sklerose, Universitatsklinikum 
      Hamburg-Eppendorf, Hamburg, Germany.
FAU - Heesen, Christoph
AU  - Heesen C
AUID- ORCID: 0000-0001-8131-9467
AD  - Institut fur Neuroimmunologie und Multiple Sklerose, Universitatsklinikum 
      Hamburg-Eppendorf, Hamburg, Germany/Klinik und Poliklinik fur Neurologie, 
      Universitatsklinikum Hamburg-Eppendorf, Hamburg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20200312
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
SB  - IM
MH  - Consensus
MH  - Exercise
MH  - Humans
MH  - *Multiple Sclerosis/therapy
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - Consensus
OT  - exercise
OT  - multiple sclerosis
OT  - recommendations
OT  - rehabilitation
EDAT- 2020/03/13 06:00
MHDA- 2021/09/25 06:00
CRDT- 2020/03/13 06:00
PHST- 2020/03/13 06:00 [pubmed]
PHST- 2021/09/25 06:00 [medline]
PHST- 2020/03/13 06:00 [entrez]
AID - 10.1177/1352458520910360 [doi]
PST - ppublish
SO  - Mult Scler. 2020 Oct;26(11):1303-1308. doi: 10.1177/1352458520910360. Epub 2020 
      Mar 12.