PMID- 32162770
OWN - NLM
STAT- MEDLINE
DCOM- 20210817
LR  - 20220716
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Print)
IS  - 1520-7552 (Linking)
VI  - 36
IP  - 6
DP  - 2020 Sep
TI  - Statins are associated with new onset type 2 diabetes mellitus (T2DM) in Medicare 
      patients >/=65 years.
PG  - e3310
LID - 10.1002/dmrr.3310 [doi]
AB  - BACKGROUND: To evaluate the association of statins and co-morbidities with new 
      onset type 2 diabetes mellitus (T2DM) in patients 65 years and older. METHODS: 
      This retrospective study used de-identified administrative healthcare claims and 
      enrolment data from a Medicare Advantage Prescription Drug (MAPD) health plan 
      offered by a large multistate healthcare company. The plan covered >2.4 million 
      individuals, of whom >1.7 million individuals were >/=65 years. Of these, 265 554 
      individuals had continuous MAPD enrolment January 2008 to December 2015. The 
      unadjusted model assessed demographic, pharmacy and T2DM co-morbidities as 
      covariates. Significant variables (P < .05) in the unadjusted model were then 
      included in the adjusted model. The adjusted model used Cox proportional hazards 
      to evaluate covariate effects. Matched propensity score analysis was used to 
      analyse the association of statins and T2DM onset. RESULTS: The cumulative rate 
      of diagnosed T2DM onset in the study cohort was 4.82% (4314/89 390). Annualised 
      incidence of T2DM diagnosis was 0.82%, 0.88%, 1.04% and 2.09% in 2012, 2013, 2014 
      and 2015, respectively. T2DM onset was associated with male sex, non-white 
      (African American or Hispanic ethnicity), statin use, hypertension, 
      hyperlipidaemia, heart failure, lower limb ulceration, atherosclerosis, other 
      retinopathy, angina pectoris, poor vision and blindness and absence ischaemic 
      heart disease (IHD). Matched propensity score analysis showed that statin use was 
      significantly associated with T2DM onset (Odds Ratio = 1.26, 95% Confidence 
      Interval: 1.12-1.41, P < .0001) in the adjusted model. CONCLUSIONS: Analyses 
      indicated that statin usage was associated with new onset T2DM after adjusting 
      for covariates.
CI  - (c) 2020 John Wiley & Sons Ltd.
FAU - Tangelloju, Srikanth
AU  - Tangelloju S
AUID- ORCID: 0000-0001-9560-4058
AD  - HUMANA Inc., Louisville, Kentucky, USA.
AD  - School of Public Health and Information Sciences, Department of Health Management 
      and Systems Sciences, University of Louisville, Louisville, Kentucky, USA.
FAU - Little, Bert B
AU  - Little BB
AUID- ORCID: 0000-0002-6485-4641
AD  - School of Public Health and Information Sciences, Department of Health Management 
      and Systems Sciences, University of Louisville, Louisville, Kentucky, USA.
FAU - Esterhay, Robert J
AU  - Esterhay RJ
AD  - School of Public Health and Information Sciences, Department of Health Management 
      and Systems Sciences, University of Louisville, Louisville, Kentucky, USA.
FAU - Brock, Guy
AU  - Brock G
AD  - Department of Biostatistics and Center for Biostatistics, Ohio State University, 
      Columbus, Ohio, USA.
FAU - LaJoie, Scott
AU  - LaJoie S
AD  - School of Public Health and Information Sciences, Department of Behavioral 
      Science and Health Promotion, University of Louisville, Louisville, Kentucky, 
      USA.
LA  - eng
GR  - UL1 TR002733/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20200403
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
SB  - IM
MH  - Age of Onset
MH  - Aged
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/chemically induced/diagnosis/*epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*adverse effects
MH  - Incidence
MH  - Male
MH  - Medicare
MH  - Prognosis
MH  - Retrospective Studies
MH  - United States/epidemiology
PMC - PMC9078214
MID - NIHMS1787153
OTO - NOTNLM
OT  - Medicare
OT  - diabetes
OT  - onset
OT  - propensity
OT  - retrospective
OT  - statin
COIS- CONFLICT OF INTEREST The authors declare that the research was conducted in the 
      absence of any commercial or financial relationships that could be construed as a 
      potential conflict of interest.
EDAT- 2020/03/13 06:00
MHDA- 2021/08/18 06:00
PMCR- 2022/05/07
CRDT- 2020/03/13 06:00
PHST- 2019/10/22 00:00 [received]
PHST- 2020/02/05 00:00 [revised]
PHST- 2020/03/07 00:00 [accepted]
PHST- 2020/03/13 06:00 [pubmed]
PHST- 2021/08/18 06:00 [medline]
PHST- 2020/03/13 06:00 [entrez]
PHST- 2022/05/07 00:00 [pmc-release]
AID - 10.1002/dmrr.3310 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2020 Sep;36(6):e3310. doi: 10.1002/dmrr.3310. Epub 2020 
      Apr 3.