PMID- 32162849
OWN - NLM
STAT- MEDLINE
DCOM- 20210511
LR  - 20210511
IS  - 2050-4527 (Electronic)
IS  - 2050-4527 (Linking)
VI  - 8
IP  - 2
DP  - 2020 Jun
TI  - Allergen-specific immunotherapy for patients with atopic dermatitis sensitized to 
      animal dander.
PG  - 165-169
LID - 10.1002/iid3.291 [doi]
AB  - INTRODUCTION: Atopic dermatitis (AD) is a chronic inflammatory skin disease, and 
      AD patients are commonly sensitized to house dust mite (HDM). Of the several 
      treatment options available, allergen-specific immunotherapy (AIT) has been 
      recognized as an effective treatment modality that is directed toward the 
      immunoglobulin E (IgE)-mediated nature of AD, and subcutaneous administration 
      using HDM is most commonly used for AIT in AD. For patients sensitized to animal 
      (dog or cat) dander, the treatment may not be easy, especially when avoiding the 
      allergen is not possible. METHODS: This study enrolled patients with AD who were 
      sensitized to cat and/or dog dander and underwent AIT (n = 19). Patients' medical 
      information was obtained, including past treatment history, treatment duration of 
      AIT, and the progress of treatment. Also, the specific IgE levels and IgG4 levels 
      were measured before and after AIT. RESULTS: A total of 19 patients with AD 
      underwent AIT using cat and/or dog dander. The patients consisted of 4 males and 
      15 females with an average age of 31.74 +/- 9.71. Only two patients had AD only, 
      and the other 17 patients had one or more concomitant allergic diseases, such as 
      allergic rhinitis, allergic asthma, or allergic conjunctivitis. Seven patients 
      were not sensitized to HDMs and only sensitized to cat and/or dog dander. The 
      duration of AIT ranged from 2 to 58 months. The symptoms of 17 patients were 
      well-controlled, requiring only topical treatment and/or oral antihistamines. One 
      patient required systemic cyclosporine, but only of low dose (25 mg/day). The 
      specific IgE levels were decreased (P = .005) and IgG4 levels showed the tendency 
      of increasing after AIT. No adverse events were observed in these patients. 
      CONCLUSION: Although a larger number of patients for a longer follow-up period 
      are needed to precisely assess the treatment efficacy, AIT using cat and/or dog 
      dander may be an effective treatment option for AD patients, especially for 
      severe AD patients with other respiratory allergic comorbidities who cannot 
      completely avoid the exposure to animal dander.
CI  - (c) 2020 The Authors. Immunity, Inflammation and Disease published by John Wiley & 
      Sons Ltd.
FAU - Chu, Howard
AU  - Chu H
AD  - Department of Dermatology, Cutaneous Biology Research Institute, Yonsei 
      University College of Medicine, Seoul, Korea.
FAU - Park, Kyung Hee
AU  - Park KH
AUID- ORCID: 0000-0003-3605-5364
AD  - Division of Allergy, Department of Internal Medicine, Yonsei University College 
      of Medicine, Seoul, Korea.
AD  - Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.
FAU - Kim, Su Min
AU  - Kim SM
AD  - Department of Dermatology, Cutaneous Biology Research Institute, Yonsei 
      University College of Medicine, Seoul, Korea.
FAU - Lee, Jae-Hyun
AU  - Lee JH
AD  - Division of Allergy, Department of Internal Medicine, Yonsei University College 
      of Medicine, Seoul, Korea.
AD  - Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.
FAU - Park, Jung-Won
AU  - Park JW
AD  - Division of Allergy, Department of Internal Medicine, Yonsei University College 
      of Medicine, Seoul, Korea.
AD  - Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.
FAU - Lee, Kwang Hoon
AU  - Lee KH
AD  - Department of Dermatology, Cutaneous Biology Research Institute, Yonsei 
      University College of Medicine, Seoul, Korea.
FAU - Park, Chang Ook
AU  - Park CO
AUID- ORCID: 0000-0003-3856-1201
AD  - Department of Dermatology, Cutaneous Biology Research Institute, Yonsei 
      University College of Medicine, Seoul, Korea.
AD  - Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200312
PL  - England
TA  - Immun Inflamm Dis
JT  - Immunity, inflammation and disease
JID - 101635460
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Asthma/immunology/therapy
MH  - Conjunctivitis, Allergic/immunology/therapy
MH  - Dander/immunology
MH  - Dermatitis, Atopic/*immunology/*therapy
MH  - Desensitization, Immunologic/*methods
MH  - Dogs
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood/*immunology
MH  - Immunoglobulin G/blood/*immunology
MH  - Male
MH  - Middle Aged
MH  - Pyroglyphidae/immunology
MH  - Rhinitis, Allergic/immunology/therapy
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC7212191
OTO - NOTNLM
OT  - allergen-specific immunotherapy
OT  - animal dander
OT  - atopic dermatitis
EDAT- 2020/03/13 06:00
MHDA- 2021/05/12 06:00
PMCR- 2020/03/12
CRDT- 2020/03/13 06:00
PHST- 2019/09/25 00:00 [received]
PHST- 2020/01/20 00:00 [revised]
PHST- 2020/01/22 00:00 [accepted]
PHST- 2020/03/13 06:00 [pubmed]
PHST- 2021/05/12 06:00 [medline]
PHST- 2020/03/13 06:00 [entrez]
PHST- 2020/03/12 00:00 [pmc-release]
AID - IID3291 [pii]
AID - 10.1002/iid3.291 [doi]
PST - ppublish
SO  - Immun Inflamm Dis. 2020 Jun;8(2):165-169. doi: 10.1002/iid3.291. Epub 2020 Mar 
      12.