PMID- 32164875
OWN - NLM
STAT- MEDLINE
DCOM- 20200821
LR  - 20210521
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 106
IP  - 4
DP  - 2020 May 20
TI  - Hierarchical Representations of Aggression in a Hypothalamic-Midbrain Circuit.
PG  - 637-648.e6
LID - S0896-6273(20)30137-9 [pii]
LID - 10.1016/j.neuron.2020.02.014 [doi]
AB  - Although the ventromedial hypothalamus ventrolateral area (VMHvl) is now well 
      established as a critical locus for the generation of conspecific aggression, its 
      role is complex, with neurons responding during multiple phases of social 
      interactions with both males and females. It has been previously unclear how the 
      brain uses this complex multidimensional signal and coordinates a discrete 
      action: the attack. Here, we find a hypothalamic-midbrain circuit that represents 
      hierarchically organized social signals during aggression. Optogenetic-assisted 
      circuit mapping reveals a preferential projection from VMHvl(vGlut2) to 
      lPAG(vGlut2) cells, and inactivation of downstream lPAG(vGlut2) populations 
      results in aggression-specific deficits. lPAG neurons are selective for attack 
      action and exhibit short-latency, time-locked spiking relative to the activity of 
      jaw muscles during biting. Last, we find that this projection conveys male-biased 
      signals from the VMHvl to downstream lPAG(vGlut2) neurons that are sensitive to 
      features of ongoing activity, suggesting that action selectivity is generated by 
      a combination of pre- and postsynaptic mechanisms.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Falkner, Annegret L
AU  - Falkner AL
AD  - Princeton Neuroscience Institute, Princeton, NJ 08540, USA; Neuroscience 
      Institute, New York University School of Medicine, New York, NY 10016, USA. 
      Electronic address: afalkner@princeton.edu.
FAU - Wei, Dongyu
AU  - Wei D
AD  - Neuroscience Institute, New York University School of Medicine, New York, NY 
      10016, USA.
FAU - Song, Anjeli
AU  - Song A
AD  - Boston University School of Medicine, Boston, MA 02118, USA.
FAU - Watsek, Li W
AU  - Watsek LW
AD  - Neuroscience Institute, New York University School of Medicine, New York, NY 
      10016, USA.
FAU - Chen, Irene
AU  - Chen I
AD  - Neuroscience Institute, New York University School of Medicine, New York, NY 
      10016, USA.
FAU - Chen, Patricia
AU  - Chen P
AD  - Princeton Neuroscience Institute, Princeton, NJ 08540, USA.
FAU - Feng, James E
AU  - Feng JE
AD  - Neuroscience Institute, New York University School of Medicine, New York, NY 
      10016, USA.
FAU - Lin, Dayu
AU  - Lin D
AD  - Neuroscience Institute, New York University School of Medicine, New York, NY 
      10016, USA; Department of Psychiatry, New York University School of Medicine, New 
      York, NY 10016, USA; Center for Neural Science, New York University, New York, NY 
      10003, USA.
LA  - eng
GR  - R01 HD092596/HD/NICHD NIH HHS/United States
GR  - R01 MH101377/MH/NIMH NIH HHS/United States
GR  - R00 MH109674/MH/NIMH NIH HHS/United States
GR  - U19 NS107616/NS/NINDS NIH HHS/United States
GR  - K99 MH109674/MH/NIMH NIH HHS/United States
GR  - R21 MH105774/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200311
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
SB  - IM
CIN - Nat Rev Neurosci. 2020 May;21(5):243. PMID: 32242136
CIN - Neuron. 2020 May 20;106(4):556-558. PMID: 32437653
MH  - Aggression/*physiology
MH  - Animals
MH  - Female
MH  - Male
MH  - Mesencephalon/cytology/*physiology
MH  - Mice
MH  - Neural Pathways/cytology/*physiology
MH  - Neurons/cytology/*physiology
MH  - Ventromedial Hypothalamic Nucleus/cytology/*physiology
PMC - PMC7571490
MID - NIHMS1575430
OTO - NOTNLM
OT  - aggression
OT  - circuit
OT  - hypothalamus
OT  - jaw muscle
OT  - periaqueductal gray
OT  - social behavior
COIS- Declaration of Interests The authors declare no competing interests.
EDAT- 2020/03/14 06:00
MHDA- 2020/08/22 06:00
PMCR- 2021/05/20
CRDT- 2020/03/14 06:00
PHST- 2019/03/18 00:00 [received]
PHST- 2019/12/20 00:00 [revised]
PHST- 2020/02/10 00:00 [accepted]
PHST- 2020/03/14 06:00 [pubmed]
PHST- 2020/08/22 06:00 [medline]
PHST- 2020/03/14 06:00 [entrez]
PHST- 2021/05/20 00:00 [pmc-release]
AID - S0896-6273(20)30137-9 [pii]
AID - 10.1016/j.neuron.2020.02.014 [doi]
PST - ppublish
SO  - Neuron. 2020 May 20;106(4):637-648.e6. doi: 10.1016/j.neuron.2020.02.014. Epub 
      2020 Mar 11.