PMID- 32165209
OWN - NLM
STAT- MEDLINE
DCOM- 20210209
LR  - 20210816
IS  - 1878-5867 (Electronic)
IS  - 0039-128X (Linking)
VI  - 159
DP  - 2020 Jul
TI  - Association of exposure to prenatal phthalate esters and bisphenol A and 
      polymorphisms in the ESR1 gene with the second to fourth digit ratio in 
      school-aged children: Data from the Hokkaido study.
PG  - 108637
LID - S0039-128X(20)30062-3 [pii]
LID - 10.1016/j.steroids.2020.108637 [doi]
AB  - Phthalates and bisphenol A (BPA) are estrogenic endocrine disruptors. 
      Polymorphisms in the gene encoding estrogen receptor 1 (ESR1) may contribute to 
      the ratio of the lengths of the second and fourth digits (2D:4D), which is 
      considered an index of prenatal exposure to sex hormones. Thus, we investigated 
      whether ESR1 polymorphisms modify the effects of prenatal exposure to phthalates 
      and BPA on 2D:4D in a birth cohort. Maternal serum in the first trimester was 
      used to determine prenatal exposure to these compounds. Six hundred twenty-three 
      children (7 years of age) provided mean 2D:4D from photocopies and were genotyped 
      for single nucleotide polymorphisms in ESR1, particularly PvuII (T > C, dbSNP: 
      rs2234693), XbaI (A > G, dbSNP: rs9340799), and rs2077647 (A > G). The 
      associations among compound exposure, mean 2D:4D, and ESR1 polymorphisms were 
      assessed by multiple linear regression adjusted for potential cofounding factors. 
      Boys with the AG/GG genotype at rs2077647 in the group exposed to high levels of 
      mono(2-ethylhexyl) phthalate (MEHP) or Sigma Di(2-ethylhexyl) phthalate (DEHP) showed 
      feminized 2D:4D compared with boys with the AA genotype at rs2077647 who had low 
      exposure to MEHP or SigmaDEHP (MEHP: increase in mean 2D:4D of 1.51%, 95% confidence 
      interval [CI]: 0.40-2.63; SigmaDEHP: increase in mean 2D:4D of 1.37%, 95% CI: 
      0.25-2.49). No significant differences were found among girls. There were no 
      associations between mean 2D:4D and metabolites other than MEHP or BPA. These 
      data suggest that ESR1 polymorphisms modify the effects of prenatal exposure to 
      DEHP on mean 2D:4D among boys.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Nishimura, Yoko
AU  - Nishimura Y
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Japan; Center 
      for Environmental and Health Sciences, Hokkaido University, North-12, West-7, 
      Kita-ku, Sapporo 060-0812, Japan.
FAU - Moriya, Kimihiko
AU  - Moriya K
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Japan; 
      Department of Urology, Sapporo City General Hospital, North-11, West-13, Chuo-ku, 
      Sapporo 060-8604, Japan. Electronic address: k-moriya@med.hokudai.ac.jp.
FAU - Kobayashi, Sumitaka
AU  - Kobayashi S
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Araki, Atsuko
AU  - Araki A
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Sata, Fumihiro
AU  - Sata F
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan; Health Center, Chuo University, 42-8, 
      Ichigaya-Hommura-cho, Shinjuku-ku, Tokyo 162-8473, Japan.
FAU - Mitsui, Takahiko
AU  - Mitsui T
AD  - Department of Urology, Graduate School of Medical Science, University of 
      Yamanashi, Simokato-1110, Chuo 409-3898, Japan.
FAU - Itoh, Sachiko
AU  - Itoh S
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Miyashita, Chihiro
AU  - Miyashita C
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Cho, Kazutoshi
AU  - Cho K
AD  - Maternity and Perinatal Care Center, Hokkaido University Hospital, North-14, 
      West-5 Kita-ku, Sapporo 060-8648, Japan.
FAU - Kon, Masafumi
AU  - Kon M
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Japan.
FAU - Nakamura, Michiko
AU  - Nakamura M
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Japan.
FAU - Kitta, Takeya
AU  - Kitta T
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Japan. 
      Electronic address: kitta@fb3.so-net.ne.jp.
FAU - Murai, Sachiyo
AU  - Murai S
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Japan.
FAU - Kishi, Reiko
AU  - Kishi R
AD  - Center for Environmental and Health Sciences, Hokkaido University, North-12, 
      West-7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Shinohara, Nobuo
AU  - Shinohara N
AD  - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate 
      School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200309
PL  - United States
TA  - Steroids
JT  - Steroids
JID - 0404536
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (ESR1 protein, human)
RN  - 0 (Esters)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Phenols)
RN  - 0 (Phthalic Acids)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Adult
MH  - Benzhydryl Compounds/administration & dosage/*adverse effects
MH  - Body Weights and Measures
MH  - Child
MH  - Cohort Studies
MH  - Esters/administration & dosage/*adverse effects
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Phenols/administration & dosage/*adverse effects
MH  - Phthalic Acids/administration & dosage/*adverse effects
MH  - Polymorphism, Genetic/*genetics
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/genetics
MH  - Prospective Studies
OTO - NOTNLM
OT  - Bisphenol A
OT  - Digit ratio of the hand
OT  - ESR1 polymorphism
OT  - Phthalate
EDAT- 2020/03/14 06:00
MHDA- 2021/02/10 06:00
CRDT- 2020/03/14 06:00
PHST- 2019/08/16 00:00 [received]
PHST- 2020/02/28 00:00 [revised]
PHST- 2020/03/05 00:00 [accepted]
PHST- 2020/03/14 06:00 [pubmed]
PHST- 2021/02/10 06:00 [medline]
PHST- 2020/03/14 06:00 [entrez]
AID - S0039-128X(20)30062-3 [pii]
AID - 10.1016/j.steroids.2020.108637 [doi]
PST - ppublish
SO  - Steroids. 2020 Jul;159:108637. doi: 10.1016/j.steroids.2020.108637. Epub 2020 Mar 
      9.