PMID- 32165608
OWN - NLM
STAT- MEDLINE
DCOM- 20210106
LR  - 20210106
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 26
DP  - 2020 Mar 13
TI  - Serum Levels of Cystatin C, N-Terminal Pro-B-Type Natriuretic Peptide 
      (NT-proBNP), and Cardiac Function in Patients with Unstable Angina Pectoris.
PG  - e920721
LID - 10.12659/MSM.920721 [doi]
AB  - BACKGROUND This study aimed to investigate the association between serum levels 
      of cystatin C, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and cardiac 
      function in patients with unstable angina pectoris (UAP). MATERIAL AND METHODS A 
      cross-sectional observational study was conducted at a single center and 
      recruited 300 patients (214 men and 86 women), who were diagnosed with UAP 
      between June 2018 to December 2018. The patients had serum levels of NT-ProBNP 
      measured and were divided into four groups according to the serum levels of 
      cystatin C: Q1, 0.49-0.83 mg/L; Q2, 0.84-1.04 mg/L; Q3, 1.05-1.38 mg/L; Q4, 
      1.39-4.21 mg/L. Cardiac function was graded according to the New York Heart 
      Association (NYHA) class I to IV criteria. RESULTS In the 300 patients with UAP, 
      there were significant differences in cardiac function and NT-ProBNP levels 
      between the four study groups (Q1 to Q4) (p<0.05). Univariate analysis showed 
      that body weight, heart rate, treatment with aspirin, ticagrelor, 
      angiotensin-converting enzyme inhibitor and an angiotensin receptor blocker 
      (ACE/ARB), diuretic use, uric acid level, and serum cystatin C levels were 
      significantly associated with increased levels of NT-ProBNP. After adjusting for 
      confounding factors screened in univariate analysis, multivariate regression 
      analysis showed that increased serum cystatin C levels were significantly 
      associated with increased levels of NT-ProBNP. CONCLUSIONS Increased serum levels 
      of cystatin C were associated with poor cardiac function and increased levels of 
      NT-ProBNP in patients with UAP.
FAU - Long, Manyun
AU  - Long M
AD  - Department of Cardiology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi, China (mainland).
FAU - Li, Lang
AU  - Li L
AD  - Department of Cardiology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi, China (mainland).
LA  - eng
PT  - Journal Article
DEP - 20200313
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Biomarkers)
RN  - 0 (CST3 protein, human)
RN  - 0 (Cystatin C)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Angina, Unstable/blood/*diagnosis/physiopathology
MH  - Biomarkers/blood
MH  - Cross-Sectional Studies
MH  - Cystatin C/*blood
MH  - Female
MH  - Heart/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
PMC - PMC7092660
EDAT- 2020/03/14 06:00
MHDA- 2021/01/07 06:00
PMCR- 2020/03/13
CRDT- 2020/03/14 06:00
PHST- 2020/03/14 06:00 [entrez]
PHST- 2020/03/14 06:00 [pubmed]
PHST- 2021/01/07 06:00 [medline]
PHST- 2020/03/13 00:00 [pmc-release]
AID - 920721 [pii]
AID - 10.12659/MSM.920721 [doi]
PST - epublish
SO  - Med Sci Monit. 2020 Mar 13;26:e920721. doi: 10.12659/MSM.920721.