PMID- 32166667
OWN - NLM
STAT- MEDLINE
DCOM- 20201023
LR  - 20210110
IS  - 2523-899X (Electronic)
IS  - 2523-899X (Linking)
VI  - 40
IP  - 1
DP  - 2020 Feb
TI  - Relationship between Free Thyroxine and Islet Beta-cell Function in Euthyroid 
      Subjects.
PG  - 69-77
LID - 10.1007/s11596-020-2148-6 [doi]
AB  - Thyroid hormones have a specific effect on glucose-induced insulin secretion from 
      the pancreas. We aimed to investigate the association between euthyroid hormones 
      and islet beta-cell function in general population and non-treated type 2 
      diabetes mellitus (T2DM) patients. A total of 5089 euthyroid participants 
      (including 4601 general population and 488 non-treated T2DM patients) were 
      identified from a cross-sectional survey on the prevalence of metabolic diseases 
      and risk factors in East China from February 2014 to June 2016. Anthropometric 
      indices, biochemical parameters, and thyroid hormones were measured. Compared 
      with general population, non-treated T2DM patients exhibited higher total 
      thyroxine (TT4) and free thyroxine (FT4) levels but lower ratio of free 
      triiodothyronine (T3):T4 (P<0.01). HOMA-beta had prominently negative correlation 
      with FT4 and positive relationship with free T3:T4 in both groups even after 
      adjusting for age, body mass index (BMI) and smoking. When analyzed by quartiles 
      of FT4 or free T3:T4, there were significantly decreased trend of HOMA-beta going 
      with the higher FT4 and lower free T3:T4 in both groups. Linear regression 
      analysis showed that FT4 but not FT3 and free T3:T4 was negatively associated 
      with HOMA-beta no matter in general population or T2DM patients, which was 
      independent of age, BMI, smoking, hypertension and lipid profiles. FT4 is 
      independently and negatively associated with islet beta-cell function in 
      euthyroid subjects. Thyroid hormone even in reference range could play an 
      important role in the function of pancreatic islets.
FAU - Li, Qing
AU  - Li Q
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, 
      China.
FAU - Lu, Meng
AU  - Lu M
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, 
      China.
FAU - Wang, Ning-Jian
AU  - Wang NJ
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, 
      China.
FAU - Chen, Yi
AU  - Chen Y
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, 
      China.
FAU - Chen, Ying-Chao
AU  - Chen YC
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, 
      China.
FAU - Han, Bing
AU  - Han B
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, 
      China.
FAU - Li, Qin
AU  - Li Q
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, 
      China.
FAU - Xia, Fang-Zhen
AU  - Xia FZ
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, 
      China.
FAU - Jiang, Bo-Ren
AU  - Jiang BR
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, 
      China.
FAU - Zhai, Hua-Ling
AU  - Zhai HL
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, 
      China.
FAU - Lin, Dong-Ping
AU  - Lin DP
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, 
      China. lindongping2005@126.com.
FAU - Lu, Ying-Li
AU  - Lu YL
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, 
      China. luyingli2008@126.com.
LA  - eng
PT  - Journal Article
DEP - 20200313
PL  - China
TA  - Curr Med Sci
JT  - Current medical science
JID - 101729993
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - Q51BO43MG4 (Thyroxine)
RN  - Euthyroid Goiter
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*metabolism/physiopathology
MH  - Female
MH  - Goiter, Nodular/*metabolism/physiopathology
MH  - Humans
MH  - Insulin-Secreting Cells/*metabolism
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Thyroid Function Tests
MH  - Thyroxine/*metabolism
MH  - Triiodothyronine/metabolism
OTO - NOTNLM
OT  - diabetes
OT  - euthyroid hormones
OT  - free thyroxine
OT  - free triiodothyronine
OT  - islet beta-cell function
EDAT- 2020/03/14 06:00
MHDA- 2020/10/24 06:00
CRDT- 2020/03/14 06:00
PHST- 2018/12/31 00:00 [received]
PHST- 2019/12/01 00:00 [revised]
PHST- 2020/03/14 06:00 [entrez]
PHST- 2020/03/14 06:00 [pubmed]
PHST- 2020/10/24 06:00 [medline]
AID - 10.1007/s11596-020-2148-6 [pii]
AID - 10.1007/s11596-020-2148-6 [doi]
PST - ppublish
SO  - Curr Med Sci. 2020 Feb;40(1):69-77. doi: 10.1007/s11596-020-2148-6. Epub 2020 Mar 
      13.