PMID- 32167621
OWN - NLM
STAT- MEDLINE
DCOM- 20200601
LR  - 20200601
IS  - 1349-7006 (Electronic)
IS  - 1347-9032 (Print)
IS  - 1347-9032 (Linking)
VI  - 111
IP  - 5
DP  - 2020 May
TI  - Prognostic value of HLA class I expression in patients with oral squamous cell 
      carcinoma.
PG  - 1491-1499
LID - 10.1111/cas.14388 [doi]
AB  - Human leukocyte antigen (HLA) class Ⅰ molecules play a central role in anticancer 
      immunity, but their prognostic value in oral squamous cell carcinoma (OSCC) 
      remains unclear. We examined HLA class I expression in 2 distinct tumor 
      compartments, namely, the tumor center and invasive front, and evaluated the 
      association between its expression pattern and histopathological status in 137 
      cases with OSCC. Human leukocyte antigen class Ⅰ expression was graded 
      semiquantitatively as high, low, and negative. At the invasive front of the 
      tumor, HLA class I expression was high in 72 cases (52.6%), low in 44 cases 
      (32.1%), and negative in 21 cases (15.3%). The HLA class I expression in the 
      tumor center was high in 48 cases (35.0%), low in 58 cases (42.4%), and negative 
      in 31 cases (22.6%). The 5-year overall survival and disease-specific survival 
      rates were good in cases with high HLA class I expression at the invasive front; 
      however, there was no significant difference in survival based on HLA class I 
      expression in the tumor center. In addition, high HLA class I expression was 
      correlated with high CD8(+) T cell density, whereas negative HLA class I 
      expression was correlated with low CD8(+) T cell density at the invasive front. 
      These results suggest that it is easier for CD8(+) T cells to recognize presented 
      peptides in the case of high HLA class Ⅰ expression at the tumor invasive front 
      and could be a prognostic factor for OSCC.
CI  - (c) 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd 
      on behalf of Japanese Cancer Association.
FAU - Koike, Kazushige
AU  - Koike K
AUID- ORCID: 0000-0001-6880-2454
AD  - Department of Oral Surgery, Sapporo Medical University School of Medicine, 
      Sapporo, Japan.
FAU - Dehari, Hironari
AU  - Dehari H
AD  - Department of Oral Surgery, Sapporo Medical University School of Medicine, 
      Sapporo, Japan.
FAU - Shimizu, Shota
AU  - Shimizu S
AD  - Department of Oral Surgery, Sapporo Medical University School of Medicine, 
      Sapporo, Japan.
FAU - Nishiyama, Koyo
AU  - Nishiyama K
AD  - Department of Oral Surgery, Sapporo Medical University School of Medicine, 
      Sapporo, Japan.
FAU - Sonoda, Tomoko
AU  - Sonoda T
AD  - Department of Public Health, Sapporo Medical University School of Medicine, 
      Sapporo, Japan.
FAU - Ogi, Kazuhiro
AU  - Ogi K
AD  - Department of Oral Surgery, Sapporo Medical University School of Medicine, 
      Sapporo, Japan.
FAU - Kobayashi, Junichi
AU  - Kobayashi J
AD  - Department of Oral Surgery, Sapporo Medical University School of Medicine, 
      Sapporo, Japan.
FAU - Sasaki, Takanori
AU  - Sasaki T
AD  - Department of Oral Surgery, Sapporo Medical University School of Medicine, 
      Sapporo, Japan.
FAU - Sasaya, Takashi
AU  - Sasaya T
AD  - Department of Oral Surgery, Sapporo Medical University School of Medicine, 
      Sapporo, Japan.
FAU - Tsuchihashi, Kei
AU  - Tsuchihashi K
AD  - Department of Oral Surgery, Sapporo Medical University School of Medicine, 
      Sapporo, Japan.
FAU - Tsukahara, Tomohide
AU  - Tsukahara T
AUID- ORCID: 0000-0002-3678-4359
AD  - Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, 
      Japan.
FAU - Hasegawa, Tadashi
AU  - Hasegawa T
AD  - Department of Surgical Pathology, Sapporo Medical University School of Medicine, 
      Sapporo, Japan.
FAU - Torigoe, Toshihiko
AU  - Torigoe T
AD  - Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, 
      Japan.
FAU - Hiratsuka, Hiroyoshi
AU  - Hiratsuka H
AD  - Department of Oral Surgery, Sapporo Medical University School of Medicine, 
      Sapporo, Japan.
FAU - Miyazaki, Akihiro
AU  - Miyazaki A
AUID- ORCID: 0000-0003-3290-6205
AD  - Department of Oral Surgery, Sapporo Medical University School of Medicine, 
      Sapporo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20200415
PL  - England
TA  - Cancer Sci
JT  - Cancer science
JID - 101168776
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - CD8-Positive T-Lymphocytes/metabolism
MH  - Carcinoma, Squamous Cell/*diagnosis/metabolism/*mortality/pathology
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Histocompatibility Antigens Class I/genetics/*metabolism
MH  - Humans
MH  - Lymphocytes, Tumor-Infiltrating/metabolism
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*diagnosis/metabolism/*mortality/pathology
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Survival Rate
PMC - PMC7226222
OTO - NOTNLM
OT  - HLA class Ⅰ
OT  - oral squamous cell carcinoma
OT  - prognostic factor
OT  - survival
OT  - tumor-infiltrating lymphocyte
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2020/03/14 06:00
MHDA- 2020/06/02 06:00
PMCR- 2020/05/01
CRDT- 2020/03/14 06:00
PHST- 2019/12/18 00:00 [received]
PHST- 2020/03/06 00:00 [revised]
PHST- 2020/03/09 00:00 [accepted]
PHST- 2020/03/14 06:00 [pubmed]
PHST- 2020/06/02 06:00 [medline]
PHST- 2020/03/14 06:00 [entrez]
PHST- 2020/05/01 00:00 [pmc-release]
AID - CAS14388 [pii]
AID - 10.1111/cas.14388 [doi]
PST - ppublish
SO  - Cancer Sci. 2020 May;111(5):1491-1499. doi: 10.1111/cas.14388. Epub 2020 Apr 15.