PMID- 32169326
OWN - NLM
STAT- MEDLINE
DCOM- 20210729
LR  - 20210729
IS  - 0035-3787 (Print)
IS  - 0035-3787 (Linking)
VI  - 176
IP  - 9
DP  - 2020 Nov
TI  - Nonconvulsive status epilepticus in the elderly.
PG  - 701-709
LID - S0035-3787(20)30391-X [pii]
LID - 10.1016/j.neurol.2019.12.007 [doi]
AB  - There is a higher incidence of status epilepticus in the older adult population 
      that commonly presents as nonconvulsive status epilepticus (NCSE). NCSE most 
      often corresponds to prolonged focal seizures with impaired consciousness with 
      three main clinical presentations: i) an unexplained acute confusional state, ii) 
      subtle eye, motor or behavioral signs or mood changes and iii) typical temporal 
      or frontal seizures with impaired consciousness. Focal seizures without impaired 
      consciousness or de novo absence status of late onset may also be met. The 
      identified risk factors for NCSE onset are: a precession by a generalized 
      tonic-clonic seizure, a known history of epilepsy, female gender, and an acute 
      symptomatic cause or a known brain injury (especially a stroke sequelae). 
      Diagnosis in this population may be difficult, as the clinical presentation is 
      often not very suggestive (stupor, confusion, even coma), and requires an 
      unrestricted use of EEG with an EEG diagnosis based on the EEG with now accepted 
      criteria (so-called Salzburg EEG criteria). The treatment is based first on the 
      injection of benzodiazepines and in the second line on intravenous or oral or 
      gastric tube administration of antiepileptic drugs. It is not recommended to 
      resort to an intubation-ventilation (except necessary to treat respiratory 
      distress, multi-organ failure...). Prognosis is poor with about 30% mortality.
CI  - Copyright (c) 2020 Elsevier Masson SAS. All rights reserved.
FAU - Dupont, S
AU  - Dupont S
AD  - Epilepsy Unit, hopital de la Pitie-Salpetriere, AP-HP, Paris, France; 
      Rehabilitation Unit, hopital de la Pitie-Salpetriere, AP-HP, Paris, France; 
      UMPC-UMR 7225 CNRS-UMRS 975 Inserm, centre de recherche, institut du cerveau et 
      de la moelle epiniere (ICM), Paris, France; Universite Paris Sorbonne, Paris, 
      France. Electronic address: sophie.dupont@psl.aphp.fr.
FAU - Kinugawa, K
AU  - Kinugawa K
AD  - Functional Explorations Unit for the older patients, 
      Pitie-Salpetriere-Charles-Foix group, Charles-Foix Hospital, AP-HP, 94200 
      Ivry-sur-Seine, France; CNRS, UMR 8256 Biological Adaptation and Aging, Sorbonne 
      Universite, 75005 Paris, France.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200310
PL  - France
TA  - Rev Neurol (Paris)
JT  - Revue neurologique
JID - 2984779R
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Aged
MH  - Anticonvulsants/therapeutic use
MH  - Coma
MH  - Electroencephalography
MH  - Humans
MH  - Seizures
MH  - *Status Epilepticus
OTO - NOTNLM
OT  - Confusion
OT  - EEG
OT  - Elderly
OT  - Nonconvulsive status epilepticus
OT  - Stroke
EDAT- 2020/03/15 06:00
MHDA- 2021/07/30 06:00
CRDT- 2020/03/15 06:00
PHST- 2019/10/29 00:00 [received]
PHST- 2019/12/11 00:00 [revised]
PHST- 2019/12/17 00:00 [accepted]
PHST- 2020/03/15 06:00 [pubmed]
PHST- 2021/07/30 06:00 [medline]
PHST- 2020/03/15 06:00 [entrez]
AID - S0035-3787(20)30391-X [pii]
AID - 10.1016/j.neurol.2019.12.007 [doi]
PST - ppublish
SO  - Rev Neurol (Paris). 2020 Nov;176(9):701-709. doi: 10.1016/j.neurol.2019.12.007. 
      Epub 2020 Mar 10.