PMID- 32169792
OWN - NLM
STAT- MEDLINE
DCOM- 20210715
LR  - 20210715
IS  - 1532-2955 (Electronic)
IS  - 1087-0792 (Linking)
VI  - 51
DP  - 2020 Jun
TI  - The economic and societal burden of excessive daytime sleepiness in patients with 
      obstructive sleep apnea.
PG  - 101275
LID - S1087-0792(20)30018-6 [pii]
LID - 10.1016/j.smrv.2020.101275 [doi]
AB  - Excessive daytime sleepiness (EDS) is common in patients with obstructive sleep 
      apnea (OSA) and continues to persist in many patients despite adequate OSA 
      treatment. EDS in OSA is associated with decreased quality of life (QOL) as well 
      as increased societal burden, which may impact health care utilization and costs. 
      However, economic burden is often not the primary focus in the treatment of EDS 
      in OSA. This targeted literature review aimed to examine the published literature 
      on the economic burden of EDS in OSA. This review identified available literature 
      using a targeted PubMed search strategy using search terms related to EDS in OSA 
      in adults. Results demonstrate that there are few studies that detailed the 
      direct costs associated with EDS in OSA, though several studies indicated an 
      association between EDS in OSA and indirect economic burdens, including motor 
      vehicle accidents (MVAs), near misses, work productivity, mood, and QOL. Data 
      from the literature confirmed that persistent EDS in OSA following continuous 
      positive airway pressure persists in 12%-65% of patients. Future studies should 
      further describe the direct costs of EDS in OSA, quantify the cost associated 
      with MVAs and lost work productivity, and detail QOL and social impacts of the 
      condition.
CI  - Copyright (c) 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
FAU - Leger, Damien
AU  - Leger D
AD  - Universite Paris Descartes, EA 7330 VIFASOM (Vigilance Fatigue Sommeil et sante 
      Publique), Paris, France; Assistance Publique Hopitaux de Paris, APHP-5, Hotel 
      Dieu de Paris, Centre du Sommeil et de la Vigilance, Paris, France. Electronic 
      address: damien.leger@aphp.fr.
FAU - Stepnowsky, Carl
AU  - Stepnowsky C
AD  - University of California, San Diego, CA, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200217
PL  - England
TA  - Sleep Med Rev
JT  - Sleep medicine reviews
JID - 9804678
SB  - IM
MH  - Accidents, Traffic/economics/statistics & numerical data
MH  - Continuous Positive Airway Pressure/*instrumentation
MH  - Disorders of Excessive Somnolence/*economics/*epidemiology/etiology
MH  - Humans
MH  - Patient Acceptance of Health Care/statistics & numerical data
MH  - Quality of Life
MH  - *Sleep Apnea, Obstructive/complications/therapy
MH  - Work Performance/economics/statistics & numerical data
OTO - NOTNLM
OT  - Economic burden
OT  - Excessive daytime sleepiness
OT  - Health care utilization
OT  - Motor vehicle accident
OT  - Obstructive sleep apnea
OT  - Quality of life
OT  - Work productivity
COIS- Conflicts of interest D. Leger: Dr. Damien Leger is or has been consulted as the 
      main investigator in studies sponsored by Actelion, Agence Spatiale Europeenne, 
      Ag2R, Bioprojet, CNES, DGA, iSommeil, Jazz, Vanda, Merck, NASA, Philips, ResMed, 
      Sanofi, Rhythm, Vinci Foundation, and VitalAire in the last five years. He 
      declares no conflict of interest in relation to this manuscript. C. Stepnowsky: 
      Dr. Carl Stepnowsky has no disclosures to report.
EDAT- 2020/03/15 06:00
MHDA- 2021/07/16 06:00
CRDT- 2020/03/15 06:00
PHST- 2018/12/11 00:00 [received]
PHST- 2019/12/02 00:00 [revised]
PHST- 2019/12/19 00:00 [accepted]
PHST- 2020/03/15 06:00 [pubmed]
PHST- 2021/07/16 06:00 [medline]
PHST- 2020/03/15 06:00 [entrez]
AID - S1087-0792(20)30018-6 [pii]
AID - 10.1016/j.smrv.2020.101275 [doi]
PST - ppublish
SO  - Sleep Med Rev. 2020 Jun;51:101275. doi: 10.1016/j.smrv.2020.101275. Epub 2020 Feb 
      17.