PMID- 32170671
OWN - NLM
STAT- MEDLINE
DCOM- 20211119
LR  - 20211119
IS  - 1522-1709 (Electronic)
IS  - 1520-9512 (Linking)
VI  - 24
IP  - 4
DP  - 2020 Dec
TI  - TLR2 antagonism attenuates the hippocampal neuronal damage in a murine model of 
      sleep apnea via inhibiting neuroinflammation and oxidative stress.
PG  - 1613-1621
LID - 10.1007/s11325-020-02030-3 [doi]
AB  - BACKGROUND: Obstructive sleep apnea (OSA) in humans chronically promotes the 
      neuronal damage in the hippocampus. Toll-like receptor 2 (TLR2) is pivotal for 
      the development of numerous hippocampal diseases. Chronic intermittent hypoxia 
      (CIH) is a prominent feature of OSA. Here in our study, the effects of TLR2 
      antagonism on the neural damage elicited by CIH were examined. METHODS: 
      Ortho-vanillin (O-vanillin) is an inhibitor of TLR2. Adult male mice were 
      subjected to 8 h of intermittent hypoxia per day with or without O-vanillin for 
      28 days. Neuronal damage, the number of microglia, the interaction of TLR2 with 
      its adapter protein myeloid differentiation factor 88 (MYD88), the expressions of 
      inflammatory cytokines, and the oxidative stress were observed. RESULTS: 
      O-vanillin inhibited the increased interaction of TLR2 and MyD88, the activation 
      of NFkappaB, the aggregation of microglia, the overexpression of proinflammatory 
      agents, the elevation of oxidative stress, and hippocampal neuron cell apoptosis 
      induced by CIH. CONCLUSIONS: Our experiments indicate that TLR2 antagonism may 
      alleviate the hippocampal neuronal damage caused by CIH via inhibiting 
      neuroinflammation and oxidative stress.
FAU - Deng, Yan
AU  - Deng Y
AD  - Department of Respiratory and Critical Care Medicine, Tongji Hospital, Huazhong 
      University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, Hubei, 
      China.
FAU - Liu, Kui
AU  - Liu K
AD  - Department of Respiratory and Critical Care Medicine, Tongji Hospital, Huazhong 
      University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, Hubei, 
      China.
FAU - Pan, Yueying
AU  - Pan Y
AD  - Department of Respiratory and Critical Care Medicine, Tongji Hospital, Huazhong 
      University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, Hubei, 
      China.
FAU - Ren, Jie
AU  - Ren J
AD  - Department of Respiratory and Critical Care Medicine, Tongji Hospital, Huazhong 
      University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, Hubei, 
      China.
FAU - Shang, Jin
AU  - Shang J
AD  - Department of Respiratory and Critical Care Medicine, Tongji Hospital, Huazhong 
      University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, Hubei, 
      China.
FAU - Chen, Lei
AU  - Chen L
AD  - Department of Respiratory and Critical Care Medicine, Tongji Hospital, Huazhong 
      University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, Hubei, 
      China.
FAU - Liu, Huiguo
AU  - Liu H
AD  - Department of Respiratory and Critical Care Medicine, Tongji Hospital, Huazhong 
      University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, Hubei, 
      China. hgliu@tjh.tjmu.edu.cn.
LA  - eng
GR  - 81700089/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20200313
PL  - Germany
TA  - Sleep Breath
JT  - Sleep & breathing = Schlaf & Atmung
JID - 9804161
RN  - 0 (Benzaldehydes)
RN  - 0 (Tlr2 protein, mouse)
RN  - 0 (Toll-Like Receptor 2)
RN  - 008LR748FI (2-vanillin)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Benzaldehydes/administration & dosage
MH  - Disease Models, Animal
MH  - Encephalitis/*metabolism
MH  - Hippocampus/*metabolism/pathology
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Microglia/metabolism
MH  - Neurons/*metabolism
MH  - *Oxidative Stress
MH  - Sleep Apnea Syndromes/*metabolism
MH  - Toll-Like Receptor 2/antagonists & inhibitors/*metabolism
OTO - NOTNLM
OT  - Intermittent hypoxia
OT  - Neuroinflammation
OT  - Ortho-vanillin
OT  - Sleep apnea
OT  - Toll-like receptor 2
EDAT- 2020/03/15 06:00
MHDA- 2021/11/20 06:00
CRDT- 2020/03/15 06:00
PHST- 2019/05/06 00:00 [received]
PHST- 2020/02/05 00:00 [accepted]
PHST- 2020/01/28 00:00 [revised]
PHST- 2020/03/15 06:00 [pubmed]
PHST- 2021/11/20 06:00 [medline]
PHST- 2020/03/15 06:00 [entrez]
AID - 10.1007/s11325-020-02030-3 [pii]
AID - 10.1007/s11325-020-02030-3 [doi]
PST - ppublish
SO  - Sleep Breath. 2020 Dec;24(4):1613-1621. doi: 10.1007/s11325-020-02030-3. Epub 
      2020 Mar 13.