PMID- 32170674
OWN - NLM
STAT- MEDLINE
DCOM- 20210129
LR  - 20210129
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 45
IP  - 5
DP  - 2020 May
TI  - Pannexin-1 Channel Regulates ATP Release in Epilepsy.
PG  - 965-971
LID - 10.1007/s11064-020-02981-9 [doi]
AB  - With the deepening of research on epilepsy in recent decades, great progress has 
      been made in the diagnosis and treatment of the disease. However, the clinical 
      outcome remains unsatisfactory due to the confounding symptoms and complications, 
      as well as complex intrinsic pathogenesis. A better understanding of the 
      pathogenesis of epilepsy should be able to hinder the progress of the disease and 
      improve the therapeutic effectiveness. Since the discovery of pannexin (Panx), 
      unremitting efforts on the study of this gap junction protein family member have 
      revealed its role in participating in the expression of various 
      physiopathological processes. Among them, the activation or inhibition of Panx 
      channel has been shown to regulate the release of adenosine triphosphate (ATP) 
      and other signals, which is very important for the onset and control of nervous 
      system diseases including epilepsy. In this article, we summarize the factors 
      influencing the regulation of Panx channel opening, hoping to find a way to 
      interfere with the activation or inhibition of Panx channel that regulates the 
      signal transduction of ATP and other factors so as to control the progression of 
      epilepsy and improve the quality of life of epileptic patients who fail to 
      respond to the existing medical therapies and those at risk of surgical 
      treatment.
FAU - Shan, Yisi
AU  - Shan Y
AD  - Nantong University, Nantong, China.
FAU - Ni, Yaohui
AU  - Ni Y
AD  - Department of Neurology, Affiliated Hospital of Nantong University, Nantong, 
      China.
FAU - Gao, Zhiwei
AU  - Gao Z
AD  - Department of Neurology, Affiliated Hospital of Nantong University, Nantong, 
      China. gzw1956@163.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200313
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Connexins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (PANX1 protein, human)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
MH  - Adenosine Triphosphate/*metabolism
MH  - Animals
MH  - Connexins/*metabolism
MH  - Epilepsy/diagnosis/*metabolism/therapy
MH  - Humans
MH  - Nerve Tissue Proteins/*metabolism
MH  - Signal Transduction/physiology
OTO - NOTNLM
OT  - Adenosine triphosphate (ATP)
OT  - Epilepsy
OT  - N-methyl-D-aspartate receptor (NMDAR)
OT  - Panx1
OT  - Purinergic P2X receptor (P2X7R)
EDAT- 2020/03/15 06:00
MHDA- 2021/01/30 06:00
CRDT- 2020/03/15 06:00
PHST- 2019/08/19 00:00 [received]
PHST- 2020/02/01 00:00 [accepted]
PHST- 2020/01/16 00:00 [revised]
PHST- 2020/03/15 06:00 [pubmed]
PHST- 2021/01/30 06:00 [medline]
PHST- 2020/03/15 06:00 [entrez]
AID - 10.1007/s11064-020-02981-9 [pii]
AID - 10.1007/s11064-020-02981-9 [doi]
PST - ppublish
SO  - Neurochem Res. 2020 May;45(5):965-971. doi: 10.1007/s11064-020-02981-9. Epub 2020 
      Mar 13.