PMID- 32170765
OWN - NLM
STAT- MEDLINE
DCOM- 20210623
LR  - 20210623
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 34
IP  - 6
DP  - 2020 Jun
TI  - Incidence, risk factors, and clinical outcomes associated with Epstein-Barr 
      virus-DNAemia and Epstein-Barr virus-associated disease in patients after 
      haploidentical allogeneic stem cell transplantation: A single-center study.
PG  - e13856
LID - 10.1111/ctr.13856 [doi]
AB  - Human leukocyte antigen (HLA)-haploidentical hematopoietic stem cell 
      transplantation (haplo-HSCT) is an effective alternative to HLA-matched 
      transplantation. However, Epstein-Barr virus (EBV) infection causes morbidity and 
      mortality in patients undergoing haplo-HSCT. Here, we retrospectively evaluated 
      the incidence and risk factors of EBV-DNAemia and EBV-associated diseases in 131 
      patients who underwent haplo-HSCT. Patients were classified into the no EBV 
      infection groups, EBV-DNAemia group and EBV-associated disease group. Cumulative 
      incidences of acute graft-vs-host disease, EBV infections, overall survival (OS), 
      and relapse were analyzed. The cumulative incidences of EBV-DNAemia and 
      EBV-associated disease were 26.9% and 33.3%, respectively. In multivariate 
      analysis, cytomegalovirus (CMV)-DNAemia was confirmed as an independent risk 
      factor associated with EBV-DNAemia and EBV-associated disease. Patients with 
      EBV-associated disease had higher transplant-related mortality (TRM) rates and 
      lower OS rates, but similar relapse rates. Overall, these findings demonstrated 
      the cumulative incidences of EBV-DNAemia and EBV-associated disease and 
      identified correlations of EBV infection with TRM, relapse, and OS. Additionally, 
      CMV-DNAemia was a risk factor for EBV-DNAemia and EBV-associated disease.
CI  - (c) 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Zhou, Ling
AU  - Zhou L
AUID- ORCID: 0000-0001-8518-1733
AD  - The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
FAU - Gao, Zhi-Yong
AU  - Gao ZY
AD  - Shanghai Dao-Pei Hospital, Shanghai, China.
FAU - Lu, Dao-Pei
AU  - Lu DP
AD  - The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
AD  - Shanghai Dao-Pei Hospital, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20200407
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
SB  - IM
MH  - *Epstein-Barr Virus Infections/epidemiology/etiology
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Herpesvirus 4, Human/genetics
MH  - Humans
MH  - Incidence
MH  - Retrospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Epstein-Barr virus-DNAemia
OT  - Epstein-Barr virus-associated disease
OT  - haploidentical hematopoietic stem cell transplantation
EDAT- 2020/03/15 06:00
MHDA- 2021/06/24 06:00
CRDT- 2020/03/15 06:00
PHST- 2020/02/06 00:00 [received]
PHST- 2020/03/10 00:00 [accepted]
PHST- 2020/03/15 06:00 [pubmed]
PHST- 2021/06/24 06:00 [medline]
PHST- 2020/03/15 06:00 [entrez]
AID - 10.1111/ctr.13856 [doi]
PST - ppublish
SO  - Clin Transplant. 2020 Jun;34(6):e13856. doi: 10.1111/ctr.13856. Epub 2020 Apr 7.