PMID- 32170821
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1478-3231 (Electronic)
IS  - 1478-3223 (Linking)
VI  - 40
IP  - 6
DP  - 2020 Jun
TI  - International and multicenter real-world study of sorafenib-treated patients with 
      hepatocellular carcinoma under dialysis.
PG  - 1467-1476
LID - 10.1111/liv.14436 [doi]
AB  - BACKGROUND & AIMS: Information on safety and efficacy of systemic treatment in 
      patients with hepatocellular carcinoma (HCC) under dialysis are limited due to 
      patient exclusion from clinical trials. Thus, we aimed to evaluate the rate, 
      prevalence, tolerability, and outcome of sorafenib in this population. METHODS: 
      We report a multicenter study comprising patients from Latin America and Europe. 
      Patients treated with sorafenib were enrolled; demographics, dose modifications, 
      adverse events (AEs), treatment duration, and outcome of patients undergoing 
      dialysis were recorded. RESULTS: As of March 2018, 6156 HCC patients were treated 
      in 44 centres and 22 patients were concomitantly under dialysis (0.36%). The 
      median age was 65.5 years, 40.9% had hepatitis C, 75% had Child-Pugh A, and 85% 
      were Barcelona Clinic Liver Cancer-C. The median time to first dose modification, 
      treatment duration and overall survival rate were 2.4 months (interquartile 
      ranges [IQR], 0.8-3.8), 10.8 months (IQR, 4.5-16.9), and 17.5 months (95% CI, 
      7.2-24.5), respectively. Seventeen patients required at least 1 dose 
      modification. The main causes of first dose modification were asthenia/worsening 
      of Eastern Cooperative Oncology Group-Performance Status and diarrhoea. At the 
      time of death or last follow-up, four patients were still on treatment and 18 had 
      discontinued sorafenib: 14 were due to tumour progression, 2 were 
      sorafenib-related, and 2 were non-sorafenib-related AE. CONCLUSIONS: The outcomes 
      observed in this cohort seem comparable to those in the non-dialysis population. 
      Thus, to the best of our knowledge, this is the largest and most informative 
      dataset regarding systemic treatment outcomes in HCC patients undergoing 
      dialysis.
CI  - (c) 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Diaz-Gonzalez, Alvaro
AU  - Diaz-Gonzalez A
AUID- ORCID: 0000-0003-3610-2263
AD  - Barcelona Clinic Liver Cancer (BCLC) Group, Liver Unit, Hospital Clinic of 
      Barcelona, IDIBAPS, Barcelona, Spain.
FAU - Sanduzzi-Zamparelli, Marco
AU  - Sanduzzi-Zamparelli M
AUID- ORCID: 0000-0003-3795-3705
AD  - Barcelona Clinic Liver Cancer (BCLC) Group, Liver Unit, Hospital Clinic of 
      Barcelona, IDIBAPS, Barcelona, Spain.
FAU - da Fonseca, Leonardo G
AU  - da Fonseca LG
AUID- ORCID: 0000-0002-0216-3618
AD  - Barcelona Clinic Liver Cancer (BCLC) Group, Liver Unit, Hospital Clinic of 
      Barcelona, IDIBAPS, Barcelona, Spain.
FAU - Di Costanzo, Giovan G
AU  - Di Costanzo GG
AUID- ORCID: 0000-0001-8901-1811
AD  - Department of Transplantation, Liver Unit, Cardarelli Hospital, Naples, Italy.
FAU - Alves, Rogerio
AU  - Alves R
AD  - State Public Hospital, Sao Paulo, Brazil.
FAU - Iavarone, Massimo
AU  - Iavarone M
AUID- ORCID: 0000-0003-3493-6504
AD  - CRC "A. M. and A. Migliavacca" Center for Liver Disease, Division of 
      Gastroenterology and Hepatology, IRCCS Ca Granda Ospedale Maggiore Policlinico, 
      University of Milan, Milan, Italy.
FAU - Leal, Cassia
AU  - Leal C
AD  - Gastroenterology and Hepatology Department, Federal Hospital of State Servants 
      and Fluminense Federal University (Hospital Universitario Antonio Pedro), Rio de 
      Janeiro, Brazil.
FAU - Sacco, Rodolfo
AU  - Sacco R
AD  - Gastroenterology and Metabolic Diseases, Pisa University Hospital, Pisa, Italy.
FAU - Matilla, Ana M
AU  - Matilla AM
AD  - Digestive Diseases Department, University General Hospital Gregorio Maranon, 
      Madrid, Spain.
FAU - Hernandez-Guerra, Manuel
AU  - Hernandez-Guerra M
AUID- ORCID: 0000-0002-3478-9981
AD  - Liver Unit, Canary Island University Hospital, La Laguna, Spain.
FAU - Aballay Soteras, Gabriel
AU  - Aballay Soteras G
AD  - Liver Transplant Unit, Hospital General de Agudos Dr Cosme Argerich, Buenos Aires 
      Autonomous City, Argentina.
FAU - Worns, Marcus-Alexander
AU  - Worns MA
AUID- ORCID: 0000-0001-5815-7789
AD  - First Department of Medicine, University Medical Centre of the Johannes 
      Gutenberg-University Mainz, Mainz, Germany.
FAU - Pinter, Matthias
AU  - Pinter M
AUID- ORCID: 0000-0002-7260-532X
AD  - Division of Gastroenterology & Hepatology, Department of Internal Medicine III, 
      Vienna Liver Cancer Study Group, AKH & Medical University of Vienna, Vienna, 
      Austria.
FAU - Varela, Maria
AU  - Varela M
AUID- ORCID: 0000-0003-4288-2593
AD  - Liver Unit, Central University Hospital of Asturias, Institute of Oncology of 
      Asturias (IUOPA), Foundation for Biosanitary Research and Innovation of the 
      Principality of Asturias (FINBA), Oviedo, Spain.
FAU - Ladekarl, Morten
AU  - Ladekarl M
AD  - Department of Oncology, Aarhus University Hospital, and Department of Oncology, 
      Clinical Cancer Research Center, Aalborg University Hospital, Aarhus, Denmark.
FAU - Chagas, Aline L
AU  - Chagas AL
AUID- ORCID: 0000-0002-7404-2540
AD  - Division of Clinical Gastroenterology and Hepatology, Department of 
      Gastroenterology, University of Sao Paulo School of Medicine, Cancer Institute of 
      the State of Sao Paulo, Sao Paulo, Brazil.
FAU - Minguez, Beatriz
AU  - Minguez B
AD  - Liver Unit, Department of Internal Medicine, Vall d'Hebron University Hospital, 
      Vall d'Hebron Institut of Research, Center for Biomedical Research in Liver and 
      Digestive Diseases Network (CIBERehd), Autonomous University of Barcelona, 
      Barcelona, Spain.
FAU - Arenas, Juan I
AU  - Arenas JI
AD  - Digestive Diseases Department, Donostia University Hospital, San Sebastian, 
      Spain.
FAU - Granito, Alessandro
AU  - Granito A
AD  - Unit of Internal Medicine, Department of Medical and Surgical Sciences, 
      University of Bologna, Bologna, Italy.
FAU - Sanchez-Torrijos, Yolanda
AU  - Sanchez-Torrijos Y
AD  - UCM Digestive Diseases and Center for Biomedical Research in Liver and Digestive 
      Diseases Network (CIBERehd), Institute of Biomedicine of Seville (IBiS), SeLiver 
      Group, Virgen del Rocio/CSIC/US, Sevilla, Spain.
FAU - Rojas, Angela
AU  - Rojas A
AD  - UCM Digestive Diseases and Center for Biomedical Research in Liver and Digestive 
      Diseases Network (CIBERehd), Institute of Biomedicine of Seville (IBiS), SeLiver 
      Group, Virgen del Rocio/CSIC/US, Sevilla, Spain.
FAU - Rodriguez de Lope, Carlos
AU  - Rodriguez de Lope C
AD  - Digestive Diseases Department, Marques de Valdecilla University Hospital, Marques 
      de Valdecilla Research Institute (IDIVAL), Santander, Spain.
FAU - Alvares-da-Silva, Mario R
AU  - Alvares-da-Silva MR
AD  - GI/Liver Unit, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio 
      Grande do Sul, Porto Alegre, Brazil.
FAU - Pascual, Sonia
AU  - Pascual S
AD  - Hepatic Unit, Gastroenterology Service, General University Hospital of Alicante, 
      Center for Biomedical Research in Liver and Digestive Diseases Network 
      (CIBERehd), Alicante, Spain.
FAU - Rimassa, Lorenza
AU  - Rimassa L
AUID- ORCID: 0000-0001-9957-3615
AD  - Medical Oncology and Hematology Unit, Humanitas Cancer Center, Humanitas Clinical 
      and Research Center - IRCCS, Milan, Italy.
AD  - Department of Biomedical Sciences, Humanitas University, Milan, Italy.
FAU - Lledo, Jose L
AU  - Lledo JL
AD  - Gastroenterology and Liver Diseases department, Ramon y Cajal University 
      Hospital, Center for Biomedical Research in Liver and Digestive Diseases Network 
      (CIBERehd), Madrid, Spain.
FAU - Huertas, Carlos
AU  - Huertas C
AD  - Digestive Diseases Department, Doctor Josep Trueta University Hospital, Girona, 
      Spain.
FAU - Sangro, Bruno
AU  - Sangro B
AD  - Liver Unit, University of Navarra Clinic, Health Research Institute of Navarra 
      (IDISNA), Center for Biomedical Research in Liver and Digestive Diseases Network 
      (CIBERehd), Pamplona, Spain.
FAU - Giannini, Edoardo G
AU  - Giannini EG
AUID- ORCID: 0000-0001-8526-837X
AD  - Gastroenterology Unit, Department of Internal Medicine, IRCCS-San Martino 
      Policlinico Hospital, University of Genoa, Genoa, Italy.
FAU - Delgado, Manuel
AU  - Delgado M
AD  - Digestive Diseases Department, La Coruna University Hospital, A Coruna, Spain.
FAU - Vergara, Mercedes
AU  - Vergara M
AD  - Liver Unit, Digestive Diseases Department, Parc Tauli University Hospital, Parc 
      Tauli I3PT Research and Innovation Institute, Autonomous University of Barcelona, 
      Sabadell, Spain.
FAU - Perello, Christie
AU  - Perello C
AD  - Liver Unit, Puerta de Hierro University Hospital, Puerta de Hierro Majadahonda 
      Health Research Institute (IDIPHISA), Madrid, Spain.
FAU - Lue, Alberto
AU  - Lue A
AUID- ORCID: 0000-0002-9672-6038
AD  - Digestive Diseases Department, Hepatology Unit and Liver Transplant, Lozano Blesa 
      Clinical University Hospital, Zaragoza, Spain.
FAU - Sala, Margarita
AU  - Sala M
AD  - Liver Unit, Digestive Diseases Department, Germans Trias i Pujol University 
      Hospital, Center for Biomedical Research in Liver and Digestive Diseases Network 
      (CIBERehd), Badalona, Spain.
FAU - Gallego, Adolfo
AU  - Gallego A
AD  - Digestive Diseases Department, Santa Creu i Sant Pau University Hospital, 
      Barcelona, Spain.
FAU - Coll, Susanna
AU  - Coll S
AD  - Liver Section, Gastroenterology Department, Hospital del Mar, IMIM Hospital del 
      Mar Medical Research Institute, Barcelona, Spain.
FAU - Hernaez, Tania
AU  - Hernaez T
AD  - Digestive Diseases Department, San Pedro Hospital, Logrono, Spain.
FAU - Pinero, Federico
AU  - Pinero F
AD  - Liver Unit, Austral University Hospital, Buenos Aires, Argentina.
FAU - Pereira, Gustavo
AU  - Pereira G
AUID- ORCID: 0000-0003-2768-9605
AD  - Gastroenterology and Hepatology Unit, Bonsucesso Federal Hospital, Ministry of 
      Health, Rio de Janeiro, Brazil.
FAU - Franca, Alex
AU  - Franca A
AD  - Liver Unit, Department of Medicine, Federal University of Sergipe, Sergipe, 
      Brazil.
FAU - Marin, Juan
AU  - Marin J
AD  - Pablo Tobon Uribe Hospital, Medellin, Colombia.
FAU - Anders, Margarita
AU  - Anders M
AD  - Liver Diseases and Liver Transplant Unit, German Hospital, Buenos Aires, 
      Argentina.
FAU - Mello, Vivianne
AU  - Mello V
AD  - Multidisciplinary Assistance in Oncology (AMO) Clinic, Salvador, Brazil.
FAU - Lozano, Mar
AU  - Lozano M
AD  - Digestive Diseases Department, Infanta Leonor University Hospital, Madrid, Spain.
FAU - Nault, Jean C
AU  - Nault JC
AUID- ORCID: 0000-0002-4875-9353
AD  - Cordeliers Research Center, Sorbonne University, Inserm, USPC, Paris Descartes 
      University, Paris Diderot University, Paris 13 University, Functional Genomics of 
      Solid Tumors Laboratory, Jean Verdier Hospital, Paris-Seine-Saint University 
      Hospital -Denis, Public Assistance Hospitals of Paris, Bondy, France.
FAU - Menendez, Josemaria
AU  - Menendez J
AD  - Liver Transplant and Liver Diseases Unit, Central Hospital of the Armed Forces 
      (Military Hospital), Montevideo, Uruguay.
FAU - Garcia Juarez, Ignacio
AU  - Garcia Juarez I
AD  - Gastroenterology Department, National Institute of Medical Sciences and Nutrition 
      Salvador Zubiran, City of Mexico, Mexico.
FAU - Bruix, Jordi
AU  - Bruix J
AUID- ORCID: 0000-0002-9826-0753
AD  - Barcelona Clinic Liver Cancer (BCLC) Group, Liver Unit, Hospital Clinic of 
      Barcelona, IDIBAPS, Barcelona, Spain.
FAU - Reig, Maria
AU  - Reig M
AUID- ORCID: 0000-0002-5711-9534
AD  - Barcelona Clinic Liver Cancer (BCLC) Group, Liver Unit, Hospital Clinic of 
      Barcelona, IDIBAPS, Barcelona, Spain.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20200415
PL  - United States
TA  - Liver Int
JT  - Liver international : official journal of the International Association for the 
      Study of the Liver
JID - 101160857
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Phenylurea Compounds)
RN  - 25X51I8RD4 (Niacinamide)
RN  - 9ZOQ3TZI87 (Sorafenib)
SB  - IM
MH  - Aged
MH  - *Antineoplastic Agents/adverse effects
MH  - *Carcinoma, Hepatocellular/drug therapy
MH  - Europe
MH  - Humans
MH  - *Liver Neoplasms/drug therapy
MH  - Niacinamide/adverse effects
MH  - Phenylurea Compounds/adverse effects
MH  - Renal Dialysis
MH  - Sorafenib/therapeutic use
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Hepatocellular carcinoma
OT  - adverse events
OT  - dialysis
OT  - safety
OT  - sorafenib
OT  - survival
EDAT- 2020/03/15 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/03/15 06:00
PHST- 2019/12/28 00:00 [received]
PHST- 2020/03/06 00:00 [revised]
PHST- 2020/03/09 00:00 [accepted]
PHST- 2020/03/15 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/03/15 06:00 [entrez]
AID - 10.1111/liv.14436 [doi]
PST - ppublish
SO  - Liver Int. 2020 Jun;40(6):1467-1476. doi: 10.1111/liv.14436. Epub 2020 Apr 15.