PMID- 32172074
OWN - NLM
STAT- MEDLINE
DCOM- 20201120
LR  - 20201120
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 184
DP  - 2020 May
TI  - Association between exposure to persistent organic pollutants and mercury, and 
      glucose metabolism in two Canadian Indigenous populations.
PG  - 109345
LID - S0013-9351(20)30238-3 [pii]
LID - 10.1016/j.envres.2020.109345 [doi]
AB  - BACKGROUND: The body burden of metals and persistent organic pollutants (POPs) is 
      particularly high in populations that rely on fish and other marine species for 
      sustenance. This exposure has been associated with an increased risk of type 2 
      diabetes, but results remain contrasted. OBJECTIVE: We studied this association 
      in two Indigenous populations of northern Quebec (Canada) with markedly different 
      prevalences of diabetes and levels of exposure to POPs and mercury. METHODS: As 
      part of health surveys conducted in 2004-2009, diabetes prevalence and glucose 
      metabolism (glucose, insulin, HOMA-IR, HOMA-B) in non-diabetic fasting adults 
      were assessed using similar protocols in two populations: Inuit from Nunavik 
      (n = 877) and Cree from Eeyou Istchee territory (n = 780). Blood mercury, plasma 
      polychlorinated biphenyls (PCBs), organochlorine (OC) pesticides/metabolites and 
      polybrominated diphenylethers (PBDEs) levels were measured in samples collected 
      at the time of examination. Logistic and linear regressions and restricted cubic 
      splines analyses were conducted adjusting for sex, age, waist circumference, 
      smoking and omega-3 fatty acid content in plasma phospholipids. RESULTS: Diabetes 
      prevalence was higher in Cree (20%) than in Inuit (7%), whereas environmental 
      exposure was 2 to 3-fold greater in Inuit than in Cree participants. In the range 
      of exposure common to the two populations, we observed similar linear increases 
      in the risk of diabetes with increasing contaminant exposure. Among Cree 
      participants, fasting glucose was positively associated with plasma PBDE level, 
      and HOMA-B negatively associated with concentrations of  summation operatorPCBs, 
      dichlorodiphenyldichloroethylene, PBDEs and  summation operatorOC pesticides. Among Inuit 
      participants, a trend towards reduced insulin secretion was observed in 
      association with most contaminants, but the relation was nonlinear (greater 
      reduction at intermediate levels of exposure). A significant increase in fasting 
      glucose levels was observed at elevated blood mercury levels (>16 mug/L). 
      CONCLUSION: The observed association between POPs exposure and diabetes risk in 
      the two populations studied should be confirmed using prospective design. Our 
      results suggest the need for additional research on the physiopathological 
      process through which POPs exposure may induce type 2 diabetes in these 
      Indigenous populations.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Cordier, S
AU  - Cordier S
AD  - Centre de Recherche du CHU de Quebec - Universite Laval, Quebec, Canada; Univ 
      Rennes, Inserm, EHESP, Irset (Institut de recherche en sante. environnement et 
      travail) - UMR_S1085, F-35000, Rennes, France. Electronic address: 
      sylvaine.cordier@inserm.fr.
FAU - Anassour-Laouan-Sidi, E
AU  - Anassour-Laouan-Sidi E
AD  - Centre de Recherche du CHU de Quebec - Universite Laval, Quebec, Canada.
FAU - Lemire, M
AU  - Lemire M
AD  - Centre de Recherche du CHU de Quebec - Universite Laval, Quebec, Canada; 
      Departement de medecine sociale et preventive, Universite Laval, Quebec, Canada.
FAU - Costet, N
AU  - Costet N
AD  - Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sante. environnement 
      et travail) - UMR_S1085, F-35000, Rennes, France.
FAU - Lucas, M
AU  - Lucas M
AD  - Centre de Recherche du CHU de Quebec - Universite Laval, Quebec, Canada; 
      Departement de medecine sociale et preventive, Universite Laval, Quebec, Canada.
FAU - Ayotte, P
AU  - Ayotte P
AD  - Centre de Recherche du CHU de Quebec - Universite Laval, Quebec, Canada; 
      Departement de medecine sociale et preventive, Universite Laval, Quebec, Canada; 
      Centre de toxicologie du Quebec, Institut national de sante publique du Quebec, 
      Quebec, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200307
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - FXS1BY2PGL (Mercury)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Canada
MH  - *Diabetes Mellitus, Type 2/chemically induced/epidemiology
MH  - *Environmental Pollutants/toxicity
MH  - Glucose
MH  - Humans
MH  - *Mercury/toxicity
MH  - *Polychlorinated Biphenyls
MH  - Prospective Studies
MH  - Quebec/epidemiology
OTO - NOTNLM
OT  - Diabetes
OT  - First nations
OT  - Glucose
OT  - Insulin
OT  - Inuit
OT  - Mercury
OT  - Persistent organic pollutants
COIS- Declaration of competing interests The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/03/17 06:00
MHDA- 2020/11/21 06:00
CRDT- 2020/03/16 06:00
PHST- 2019/11/18 00:00 [received]
PHST- 2020/02/29 00:00 [revised]
PHST- 2020/03/02 00:00 [accepted]
PHST- 2020/03/17 06:00 [pubmed]
PHST- 2020/11/21 06:00 [medline]
PHST- 2020/03/16 06:00 [entrez]
AID - S0013-9351(20)30238-3 [pii]
AID - 10.1016/j.envres.2020.109345 [doi]
PST - ppublish
SO  - Environ Res. 2020 May;184:109345. doi: 10.1016/j.envres.2020.109345. Epub 2020 
      Mar 7.