PMID- 32172446
OWN - NLM
STAT- MEDLINE
DCOM- 20200929
LR  - 20200929
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 111
IP  - 6
DP  - 2020 Jun
TI  - Health-related quality of life in peripheral blood stem cell donors and bone 
      marrow donors: a prospective study in Japan.
PG  - 840-850
LID - 10.1007/s12185-020-02852-7 [doi]
AB  - Understanding of the impact of stem cell donation on donors' health-related 
      quality of life (HRQOL) remains limited. A prospective observational study of 
      eligible unrelated donors enrolled in the Japan Marrow Donor Program was 
      conducted to compare HRQOL and adverse events (AEs) between peripheral blood stem 
      cell (PBSC) and bone marrow (BM) donors. In total, 107 PBSC donors and 108 BM 
      donors were enrolled. HRQOL scores for physical status were significantly lower 
      in BM donors 1 week post-harvest (P < 0.001), but there were no significant 
      differences between the two groups at baseline or 3 months post-harvest. PBSC 
      donors were more likely to experience AEs before harvest (P < 0.001). However, at 
      harvest, moderate-to-severe AEs were more common in BM donors (P = 0.001). After 
      harvest, all grades of AEs were significantly higher in BM donors (P < 0.001). 
      Among BM donors, a lower total physical score at baseline [odds ratio (OR) 1.21], 
      female sex [OR 2.71], and young donors (OR 3.08) were risk factors for 
      moderate-to-severe AEs at harvest, while among PBSC donors, only female sex (OR 
      4.86) was a risk factor. Our findings show better HRQOL during PBSC donation. 
      These data help support decision-making by potential donors.
FAU - Fujimoto, Ayumi
AU  - Fujimoto A
AD  - Department of Oncology and Hematology, Shimane University Hospital, Izumo, Japan.
FAU - Suzuki, Ritsuro
AU  - Suzuki R
AD  - Department of Oncology and Hematology, Shimane University Hospital, Izumo, Japan.
FAU - Orihara, Katsumi
AU  - Orihara K
AD  - Japan Marrow Donor Program, Tokyo, Japan.
FAU - Iida, Minako
AU  - Iida M
AD  - Department of Promotion for Blood and Marrow Transplantation, Aichi Medical 
      University School of Medicine, Nagakute, Japan.
FAU - Yamashita, Takuya
AU  - Yamashita T
AD  - Department of Hematology, St. Luke's International Hospital, Tokyo, Japan.
FAU - Nagafuji, Koji
AU  - Nagafuji K
AD  - Division of Hematology and Oncology, Department of Medicine, Kurume University 
      School of Medicine, Kurume, Japan.
FAU - Kanamori, Heiwa
AU  - Kanamori H
AD  - Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan.
FAU - Kodera, Yoshihisa
AU  - Kodera Y
AD  - Department of Promotion for Blood and Marrow Transplantation, Aichi Medical 
      University School of Medicine, Nagakute, Japan.
FAU - Miyamura, Koichi
AU  - Miyamura K
AD  - Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, 
      Japan.
FAU - Okamoto, Shinichiro
AU  - Okamoto S
AD  - Division of Hematology, Department of Medicine, Keio University School of 
      Medicine, Tokyo, Japan.
FAU - Hino, Masayuki
AU  - Hino M
AD  - Department of Hematology, Graduate School of Medicine, Osaka City University, 
      Osaka, Japan. hinom@med.osaka-cu.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20200314
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
SB  - IM
MH  - Age Factors
MH  - *Bone Marrow
MH  - Female
MH  - *Health
MH  - Humans
MH  - Japan
MH  - Male
MH  - *Peripheral Blood Stem Cells
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Risk Factors
MH  - Sex Factors
MH  - *Stem Cells
MH  - *Tissue Donors
MH  - Tissue and Organ Harvesting/*adverse effects
OTO - NOTNLM
OT  - Adverse events
OT  - Health-related quality of life
OT  - Risk factors
OT  - Stem cell donors
EDAT- 2020/03/17 06:00
MHDA- 2020/09/30 06:00
CRDT- 2020/03/16 06:00
PHST- 2019/11/01 00:00 [received]
PHST- 2020/03/02 00:00 [accepted]
PHST- 2020/03/02 00:00 [revised]
PHST- 2020/03/17 06:00 [pubmed]
PHST- 2020/09/30 06:00 [medline]
PHST- 2020/03/16 06:00 [entrez]
AID - 10.1007/s12185-020-02852-7 [pii]
AID - 10.1007/s12185-020-02852-7 [doi]
PST - ppublish
SO  - Int J Hematol. 2020 Jun;111(6):840-850. doi: 10.1007/s12185-020-02852-7. Epub 
      2020 Mar 14.