PMID- 32174058
OWN - NLM
STAT- MEDLINE
DCOM- 20210909
LR  - 20210909
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Print)
IS  - 2233-6079 (Linking)
VI  - 44
IP  - 5
DP  - 2020 Oct
TI  - Can Habitual Exercise Help Reduce Serum Concentrations of Lipophilic Chemical 
      Mixtures? Association between Physical Activity and Persistent Organic 
      Pollutants.
PG  - 764-774
LID - 10.4093/dmj.2019.0158 [doi]
AB  - BACKGROUND: Low-dose persistent organic pollutants (POPs), especially 
      organochlorine pesticides (OCPs), have emerged as a new risk factor of many 
      chronic diseases. As serum concentrations of POPs in humans are mainly determined 
      by both their release from adipose tissue to circulation and their elimination 
      from circulation, management of these internal pathways may be important in 
      controlling the serum concentrations of POPs. As habitual physical activity can 
      increase the elimination of POPs from circulation, we evaluated whether chronic 
      physical activity is related to low serum POP concentrations. METHODS: A 
      cross-sectional study of 1,850 healthy adults (age >/=20 years) without 
      cardio-metabolic diseases who participated in the U.S. National Health and 
      Nutrition Examination Survey 1999 to 2004 was conducted. Information on moderate 
      or vigorous leisure-time physical activity was obtained based on questionnaires. 
      Serum concentrations of OCPs and polychlorinated biphenyls were investigated as 
      typical POPs. RESULTS: Serum concentrations of OCPs among physically active 
      subjects were significantly lower than those among physically inactive subjects 
      (312.8 ng/g lipid vs. 538.0 ng/g lipid, P<0.001). This difference was maintained 
      after adjustment for potential confounders. When analyses were restricted to 
      physically active subjects, there were small decreases in the serum 
      concentrations of OCPs with increasing duration of physical activity, showing a 
      curvilinear relationship over the whole range of physical activity (Pquadratic 
      <0.001). In analyses stratified by age, sex, body mass index, and smoking status, 
      a strong inverse association was similarly observed among all subgroups. 
      CONCLUSION: Physical activity may assist in decreasing serum concentrations of 
      lipophilic chemical mixtures such as OCPs.
FAU - Lee, Yu-Mi
AU  - Lee YM
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Korea.
FAU - Shin, Ji-Yeon
AU  - Shin JY
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Korea.
FAU - Kim, Se-A
AU  - Kim SA
AD  - Department of Biomedical Science, Graduate School, Kyungpook National University, 
      Daegu, Korea.
AD  - BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, 
      Kyungpook National University, Daegu, Korea.
FAU - Jacobs, David R Jr
AU  - Jacobs DR Jr
AD  - Division of Epidemiology and Community Health, School of Public Health, 
      University of Minnesota, Minneapolis, MN, USA.
FAU - Lee, Duk-Hee
AU  - Lee DH
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Korea.
AD  - Department of Biomedical Science, Graduate School, Kyungpook National University, 
      Daegu, Korea.
AD  - BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, 
      Kyungpook National University, Daegu, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200511
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
RN  - 0 (Hydrocarbons, Chlorinated)
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - *Exercise
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated
MH  - Male
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - Persistent Organic Pollutants
MH  - Young Adult
PMC - PMC7643589
OTO - NOTNLM
OT  - Complex mixtures
OT  - Environmental exposure
OT  - Environmental pollutants
OT  - Exercise
OT  - Organic chemicals
OT  - Pesticides
OT  - Polychlorinated biphenyls
OT  - Adipose tissue
COIS- CONFLICTS OF INTEREST No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2020/03/17 06:00
MHDA- 2021/09/10 06:00
PMCR- 2020/10/01
CRDT- 2020/03/17 06:00
PHST- 2019/08/05 00:00 [received]
PHST- 2019/12/20 00:00 [accepted]
PHST- 2020/03/17 06:00 [pubmed]
PHST- 2021/09/10 06:00 [medline]
PHST- 2020/03/17 06:00 [entrez]
PHST- 2020/10/01 00:00 [pmc-release]
AID - 44.e3 [pii]
AID - dmj-2019-0158 [pii]
AID - 10.4093/dmj.2019.0158 [doi]
PST - ppublish
SO  - Diabetes Metab J. 2020 Oct;44(5):764-774. doi: 10.4093/dmj.2019.0158. Epub 2020 
      May 11.