PMID- 32174990
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 1735-1995 (Print)
IS  - 1735-7136 (Electronic)
IS  - 1735-1995 (Linking)
VI  - 25
DP  - 2020
TI  - A cardiac rehabilitation exercise program potentially inhibits progressive 
      inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm 
      clinical trial.
PG  - 18
LID - 10.4103/jrms.JRMS_175_18 [doi]
LID - 18
AB  - BACKGROUND: Cardiac rehabilitation exerts anti-inflammatory effect on several 
      cardiovascular diseases; however, these effects were not described for Chagas 
      cardiomyopathy, which is associated with pro-inflammatory imbalance. MATERIALS 
      AND METHODS: Ten patients with severe Chagas cardiomyopathy performed 8 months of 
      exercise training in a cardiac rehabilitation program. Interleukin-1 beta 
      (IL-1beta), IL-8, IL-10, interferon gamma (IF-gamma), tumor necrosis factor alpha 
      (TNF-alpha), and monocyte chemoattractant protein-1 (MCP-1) serum levels were 
      measured using enzyme-linked immunosorbent assay at baseline, 4, and 8 months. 
      The influence of exercise on cytokine levels was evaluated using the one-way 
      analysis of variance for repeated measurements, with Bonferroni posttest for 
      multiple comparisons. RESULTS: Levels of pro-inflammatory (TNF-alpha, IL-1beta, IL-8, 
      IF-gamma, and (MCP-1) and anti-inflammatory (IL-10) cytokines did not vary 
      significantly during the observation period. CONCLUSION: Exercise may benefit 
      patients with severe Chagas cardiomyopathy by curbing the production of 
      pro-inflammatory cytokines in this disease characterized by a continuous state of 
      inflammation.
CI  - Copyright: (c) 2020 Journal of Research in Medical Sciences.
FAU - Rodrigues Junior, Luiz Fernando
AU  - Rodrigues Junior LF
AD  - Laboratory of Clinical Research on Chagas Disease, Evandro Chagas National 
      Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, 
      Brazil.
AD  - Care Support Division, Physical Therapy Service, National Institute of 
      Cardiology, Rio de Janeiro, RJ, Brazil.
FAU - Mendes, Fernanda de Souza Nogueira Sardinha
AU  - Mendes FSNS
AD  - Laboratory of Clinical Research on Chagas Disease, Evandro Chagas National 
      Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, 
      Brazil.
FAU - Pinto, Vivian Liane Mattos
AU  - Pinto VLM
AD  - Laboratory of Clinical Research on Chagas Disease, Evandro Chagas National 
      Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, 
      Brazil.
FAU - da Silva, Paula Simplicio
AU  - da Silva PS
AD  - Laboratory of Clinical Research on Chagas Disease, Evandro Chagas National 
      Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, 
      Brazil.
FAU - Sperandio da Silva, Gilberto Marcelo
AU  - Sperandio da Silva GM
AD  - Laboratory of Clinical Research on Chagas Disease, Evandro Chagas National 
      Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, 
      Brazil.
FAU - Pinheiro, Roberta Olmo
AU  - Pinheiro RO
AD  - Leprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de 
      Janeiro, RJ, Brazil.
FAU - de Sousa, Andrea Silvestre
AU  - de Sousa AS
AD  - Laboratory of Clinical Research on Chagas Disease, Evandro Chagas National 
      Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, 
      Brazil.
FAU - Mediano, Mauro Felippe Felix
AU  - Mediano MFF
AD  - Laboratory of Clinical Research on Chagas Disease, Evandro Chagas National 
      Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, 
      Brazil.
LA  - eng
PT  - Journal Article
DEP - 20200220
PL  - India
TA  - J Res Med Sci
JT  - Journal of research in medical sciences : the official journal of Isfahan 
      University of Medical Sciences
JID - 101235599
PMC - PMC7053160
OTO - NOTNLM
OT  - Cardiac rehabilitation
OT  - Chagas cardiomyopathy
OT  - cytokines
OT  - heart failure
COIS- There are no conflicts of interest.
EDAT- 2020/03/17 06:00
MHDA- 2020/03/17 06:01
PMCR- 2020/02/20
CRDT- 2020/03/17 06:00
PHST- 2019/07/23 00:00 [received]
PHST- 2019/10/24 00:00 [revised]
PHST- 2019/12/05 00:00 [accepted]
PHST- 2020/03/17 06:00 [entrez]
PHST- 2020/03/17 06:00 [pubmed]
PHST- 2020/03/17 06:01 [medline]
PHST- 2020/02/20 00:00 [pmc-release]
AID - JRMS-25-18 [pii]
AID - 10.4103/jrms.JRMS_175_18 [doi]
PST - epublish
SO  - J Res Med Sci. 2020 Feb 20;25:18. doi: 10.4103/jrms.JRMS_175_18. eCollection 
      2020.