PMID- 32175397
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 8
IP  - 4
DP  - 2020 Feb
TI  - The factors contributing to cognitive dysfunction in type 2 diabetic patients.
PG  - 104
LID - 10.21037/atm.2019.12.113 [doi]
LID - 104
AB  - BACKGROUNDS: The aim of the research was to investigate the factors contributing 
      to cognitive dysfunction in type 2 diabetic patients, to distinguish the complex 
      relationship between diabetic retinopathy (DR) and different cognitive status. 
      METHODS: Two hundred and ninety-seven type 2 diabetes mellitus (T2DM) patients 
      were enrolled in our study. We adopted the Clinical Dementia Rating (CDR), 
      Mini-mental State Examination (MMSE) and Montreal Cognitive Assessment (MOCA) to 
      evaluate the cognitive function. Firstly, cognition status was classified into 
      dementia and non-dementia according to MMSE and CDR. Patients with non-dementia 
      were further classified into mild cognitive impairment (MCI) and normal cognition 
      status based on MOCA. The factors contributing to cognitive dysfunction were 
      analyzed. RESULTS: Among the 297 T2DM subjects, 47 were enrolled in the dementia 
      group and 174 in the MCI group according to a battery of cognitive function 
      tests, presenting a prevalence of 15.8% and 58.6% respectively. After adjustment 
      for age, sex, and education level, waist circumference and DR were risk factors 
      for dementia (OR: 1.057, P=0.011; OR: 2.197, P=0.040). Low-density lipoprotein 
      cholesterol (LDL-C) was a risk factor for MCI (OR: 1.635, P=0.047), while age at 
      T2DM onset and moderate drinking were protective factors for MCI (OR: 0.936, 
      P=0.044; OR: 0.289, P=0.004). CONCLUSIONS: MCI is common in T2DM patients. Waist 
      circumference and DR are risk factors of dementia, LDL-C is a risk factor for 
      MCI, and moderate drinking and age at T2DM onset are protective factors for MCI. 
      DR is unrelated to MCI in T2DM.
CI  - 2020 Annals of Translational Medicine. All rights reserved.
FAU - Xia, San-Shan
AU  - Xia SS
AD  - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China.
FAU - Xia, Wen-Lin
AU  - Xia WL
AD  - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China.
FAU - Huang, Jiao-Jiao
AU  - Huang JJ
AD  - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China.
FAU - Zou, Hua-Jie
AU  - Zou HJ
AD  - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China.
FAU - Tao, Jing
AU  - Tao J
AD  - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China.
FAU - Yang, Yan
AU  - Yang Y
AD  - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC7049020
OTO - NOTNLM
OT  - Type 2 diabetes mellitus (T2DM)
OT  - dementia
OT  - diabetic retinopathy (DR)
OT  - mild cognitive impairment (MCI)
COIS- Conflict of Interest: The authors have no conflicts of interest to declare.
EDAT- 2020/03/17 06:00
MHDA- 2020/03/17 06:01
PMCR- 2020/02/01
CRDT- 2020/03/17 06:00
PHST- 2020/03/17 06:00 [entrez]
PHST- 2020/03/17 06:00 [pubmed]
PHST- 2020/03/17 06:01 [medline]
PHST- 2020/02/01 00:00 [pmc-release]
AID - atm-08-04-104 [pii]
AID - 10.21037/atm.2019.12.113 [doi]
PST - ppublish
SO  - Ann Transl Med. 2020 Feb;8(4):104. doi: 10.21037/atm.2019.12.113.