PMID- 32176268
OWN - NLM
STAT- MEDLINE
DCOM- 20200630
LR  - 20200820
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Print)
IS  - 0146-0404 (Linking)
VI  - 61
IP  - 3
DP  - 2020 Mar 9
TI  - Characteristics of Focal Gamma Zone Parapapillary Atrophy.
PG  - 17
LID - 10.1167/iovs.61.3.17 [doi]
LID - 17
AB  - PURPOSE: The purpose of this study was to investigate the characteristics of 
      focal gamma-zone parapapillary atrophy (focal gammaPPA) in patients with primary 
      open-angle glaucoma (POAG) using spectral-domain optical coherence tomography 
      (SD-OCT). METHODS: Three groups of POAG eyes (n = 214) were defined according to 
      the circumferential extent of Bruch's membrane (BM) within the beta-zone PPA, as 
      follows: (1) no gammaPPA (intact BM; n = 81), (2) conventional gammaPPA (gammaPPA involving 
      the fovea-BM-opening axis; n = 89), and (3) focal gammaPPA (gammaPPA not involving the 
      fovea-BM-opening axis; n = 44). Clinical and ocular characteristics, including 
      age, axial length (AXL), and focal lamina cribrosa (LC) defects were compared 
      among the three groups. RESULTS: The focal gammaPPA group was significantly older 
      (60.6 +/- 11.0 years) and had shorter AXL (24.10 +/- 1.34 mm) than those of the 
      conventional gammaPPA group (46.2 +/- 13.8 years and 26.53 +/- 1.61 mm, respectively; P < 
      0.001). These values of the focal gammaPPA group were similar to those of the no gammaPPA 
      group (23.73 +/- 0.97 mm for AXL and 64.0 +/- 13.0 years for age). The focal gammaPPA 
      group had a significantly higher prevalence of focal LC defects than did the 
      other two groups (70.5% [31/44] for the focal gammaPPA group versus 46.1% [41/89] for 
      the conventional gammaPPA group versus 37.0% [30/81] for the no gammaPPA group; P = 
      0.002). CONCLUSIONS: Focal gammaPPA was differentiated from conventional gammaPPA by 
      older age and shorter AXL. Further, focal gammaPPA was frequently accompanied by 
      focal LC defects. Longitudinal studies elucidating whether focal LC defects and 
      focal gammaPPA share common pathogenesis are warranted.
FAU - Kim, Hae Rang
AU  - Kim HR
AD  - ,.
FAU - Weinreb, Robert N
AU  - Weinreb RN
AD  - ,.
FAU - Zangwill, Linda M
AU  - Zangwill LM
AD  - ,.
FAU - Suh, Min Hee
AU  - Suh MH
AD  - ,.
LA  - eng
GR  - R01 EY029058/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Axial Length, Eye
MH  - Bruch Membrane/diagnostic imaging/pathology
MH  - Choroid/diagnostic imaging/pathology
MH  - Female
MH  - Fovea Centralis/diagnostic imaging/pathology
MH  - Glaucoma, Open-Angle/complications/diagnostic imaging/*pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Optic Atrophy/complications/diagnostic imaging/*pathology
MH  - Optic Disk/diagnostic imaging/pathology
MH  - Tomography, Optical Coherence/methods
MH  - Visual Fields
PMC - PMC7401693
COIS- Disclosure: H.R. Kim, None; R.N. Weinreb, Allergan (C), Bausch & Lomb (C), Carl 
      Zeiss Meditec (F), Eyenovia (C), Genentech (F), Heidelberg Engineering (F), 
      National Eye Institute (F), Novartis (C), Optos (F), Optovue (F), Unity (C); L.M. 
      Zangwill, Carl Zeiss Meditec (F), Heidelberg Engineering (F), Merck (C), National 
      Eye Institute (F), Optovue (F), Topcon (F); M.H. Suh, None
EDAT- 2020/03/17 06:00
MHDA- 2020/07/01 06:00
PMCR- 2020/03/16
CRDT- 2020/03/17 06:00
PHST- 2020/03/17 06:00 [entrez]
PHST- 2020/03/17 06:00 [pubmed]
PHST- 2020/07/01 06:00 [medline]
PHST- 2020/03/16 00:00 [pmc-release]
AID - 2763129 [pii]
AID - IOVS-19-27614 [pii]
AID - 10.1167/iovs.61.3.17 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2020 Mar 9;61(3):17. doi: 10.1167/iovs.61.3.17.