PMID- 32176647
OWN - NLM
STAT- MEDLINE
DCOM- 20210513
LR  - 20211118
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Print)
IS  - 1387-2877 (Linking)
VI  - 74
IP  - 1
DP  - 2020
TI  - Oxidized Products of Omega-6 and Omega-3 Long Chain Fatty Acids Are Associated 
      with Increased White Matter Hyperintensity and Poorer Executive Function 
      Performance in a Cohort of Cognitively Normal Hypertensive Older Adults.
PG  - 65-77
LID - 10.3233/JAD-191197 [doi]
AB  - BACKGROUND: Cerebrovascular disease is a common cause of dementia in older 
      adults, and potentially preventable with early intervention. Oxylipins are 
      produced from the oxidation of long-chain polyunsaturated fatty acids (PUFA) 
      possessing potent vascular effects. Oxylipins generated from the cytochrome P450 
      pathway are enzymatically converted to diols by soluble epoxide hydrolase (sEH); 
      sEH products have been associated with small vessel ischemic disease. Little is 
      known about oxylipins' impact on markers of dementia risk. OBJECTIVE: An 
      exploratory examination of the association between omega-6 and omega-3 derived 
      oxylipins, brain MRI, and cognition. METHODS: Thirty-seven non-demented 
      participants with controlled hypertension (mean age 65.6 years) were enrolled in 
      a dementia prevention study investigating fish oil and lipoic acid on preserving 
      cognitive function. Baseline associations between plasma oxylipins, white matter 
      hyperintensity (WMH), and Trails-B were examined using linear regression. 
      P450-derived diol/epoxide ratio was an indirect measure of sEH activity. RESULTS: 
      Omega-6 derived 9-HODE was associated with increased WMH (p = 0.017) and reduced 
      grey matter volume (p = 0.02). Omega-6 P450-derived diol/epoxide ratio 
      9,10-DiHOME/9,10-EpOME was associated with increased WMH (p = 0.035) and poorer 
      performance on Trails-B (p = 0.05); ratio14,15-DHET/14,15-EET was associated with 
      increased WMH (p = 0.045). Omega-3 P450-derived diol/epoxide ratio 
      19,20-DiHDPE/19,20-EpDPE was associated with increased WMH (p = 0.04) and poorer 
      performance on Trails-B (p = 0.04). Arachidonic acid was associated with better 
      performance on Trails-B (p = 0.012); Omega-3 derived 16,17-EpDPE was associated 
      with decreased WMH (p = 0.005). CONCLUSIONS: With the exception of arachidonic 
      acid, it was specific oxylipin products, not their parent PUFAs, that were 
      associated with unfavorable and favorable MRI and cognitive markers of dementia 
      risk.
FAU - Shinto, Lynne
AU  - Shinto L
AD  - Department of Neurology, Oregon Health and Science University, Portland, OR, USA.
FAU - Lahna, David
AU  - Lahna D
AD  - Department of Neurology, Oregon Health and Science University, Portland, OR, USA.
FAU - Murchison, Charles F
AU  - Murchison CF
AD  - Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, 
      USA.
FAU - Dodge, Hiroko
AU  - Dodge H
AD  - Department of Neurology, Oregon Health and Science University, Portland, OR, USA.
FAU - Hagen, Kirsten
AU  - Hagen K
AD  - Department of Neurology, Oregon Health and Science University, Portland, OR, USA.
FAU - David, Jason
AU  - David J
AD  - Department of Neurology, Oregon Health and Science University, Portland, OR, USA.
FAU - Kaye, Jeffrey
AU  - Kaye J
AD  - Department of Neurology, Oregon Health and Science University, Portland, OR, USA.
AD  - Department of Neurology, Veterans Affairs Medical Center, Portland, OR, USA.
FAU - Quinn, Joseph F
AU  - Quinn JF
AD  - Department of Neurology, Oregon Health and Science University, Portland, OR, USA.
AD  - Department of Neurology, Veterans Affairs Medical Center, Portland, OR, USA.
FAU - Wall, Rachel
AU  - Wall R
AD  - Department of Neurology, Oregon Health and Science University, Portland, OR, USA.
AD  - Department of Neurology, Veterans Affairs Medical Center, Portland, OR, USA.
FAU - Silbert, Lisa C
AU  - Silbert LC
AD  - Department of Neurology, Oregon Health and Science University, Portland, OR, USA.
AD  - Department of Neurology, Veterans Affairs Medical Center, Portland, OR, USA.
LA  - eng
GR  - P30 AG066518/AG/NIA NIH HHS/United States
GR  - R01 AG043398/AG/NIA NIH HHS/United States
GR  - M01 RR000334/RR/NCRR NIH HHS/United States
GR  - P30 AG008017/AG/NIA NIH HHS/United States
GR  - R21 AG023805/AG/NIA NIH HHS/United States
GR  - R01 AG033613/AG/NIA NIH HHS/United States
GR  - R01 AG036772/AG/NIA NIH HHS/United States
GR  - UL1 TR000128/TR/NCATS NIH HHS/United States
PT  - Journal Article
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fatty Acids, Omega-6)
RN  - 0 (Oxylipins)
SB  - IM
MH  - Aged
MH  - Brain/diagnostic imaging
MH  - Cognition/*drug effects
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - *Executive Function
MH  - Fatty Acids, Omega-3/*chemistry
MH  - Fatty Acids, Omega-6/*chemistry
MH  - Female
MH  - Humans
MH  - Hypertension/*diagnostic imaging/*psychology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Oxylipins/*adverse effects
MH  - Psychomotor Performance/drug effects
MH  - Trail Making Test
MH  - White Matter/*diagnostic imaging
PMC - PMC8597742
MID - NIHMS1751913
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - cross-sectional studies
OT  - fatty acids
OT  - humans
OT  - oxylipins
OT  - vascular dementia
EDAT- 2020/03/17 06:00
MHDA- 2021/05/14 06:00
PMCR- 2021/11/17
CRDT- 2020/03/17 06:00
PHST- 2020/03/17 06:00 [entrez]
PHST- 2020/03/17 06:00 [pubmed]
PHST- 2021/05/14 06:00 [medline]
PHST- 2021/11/17 00:00 [pmc-release]
AID - JAD191197 [pii]
AID - 10.3233/JAD-191197 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2020;74(1):65-77. doi: 10.3233/JAD-191197.