PMID- 32179061 OWN - NLM STAT- MEDLINE DCOM- 20210824 LR - 20210824 IS - 1872-7549 (Electronic) IS - 0166-4328 (Linking) VI - 386 DP - 2020 May 27 TI - Smoking cues impair monitoring but not stopping during response inhibition in abstinent male smokers. PG - 112605 LID - S0166-4328(20)30304-1 [pii] LID - 10.1016/j.bbr.2020.112605 [doi] AB - The attenuated inhibitory control of smokers is a stumbling block for treating nicotine dependence. Unfortunately, smokers are often exposed to cigarette-related salient cues, which may violate homeostasis, override self-control, and lead to relapse. To understand the mechanisms underlying these associations, we investigate the cognitive and neural processes of inhibitory control (including proactive and reactive inhibition) of smoking cues in abstinent smokers. Twenty-six smokers completed cue-reactivity and stop signal tasks during functional magnetic resonance imaging scans, on two separate sessions, 2-3 weeks apart: one involved a neutral cue reactivity task, and the other a smoking cue reactivity task. Findings pointed to no significant subjective craving changes, or behavioral influences of smoking cues on proactive and reactive inhibition. However, abstinent smokers exhibited hyperactive brain reactivity in response to smoking versus neutral stimuli, in regions including the insula, amygdala, anterior cingulate cortex (ACC), and putamen. They also had hypoactive bilateral rostral ACC (rACC) and hyperactive right pre-supplementary motor area during reactive inhibition in smoking versus neutral conditions. Support vector regression analysis showed that activation of these regions predicted and correlated with reactive inhibition index (i.e., SSRT), alluding to the possibility of their involvement in the reactive inhibition. Subjective craving scores were predicted by and correlated with activation of bilateral dorsal and rostral ACC, supporting the ideas of their possible involvement in subjective craving. These findings suggest that smoking cues evoke hyperactive brain reactivity; this may interfere with normal performance monitoring and rapid reactive inhibition. These findings have important implication for treating smoking dependence. CI - Copyright (c) 2020 Elsevier B.V. All rights reserved. FAU - Zhao, Haichao AU - Zhao H AD - Faculty of Psychology, Southwest University, 2 Tiansheng Rd, Chongqing, China; School of Biological Science and Medical Engineering, Beihang University, Beijing, China. FAU - Turel, Ofir AU - Turel O AD - Department of Psychology, and Brain and Creativity Institute, University of Southern California, Los Angeles, CA, USA; Department of Information Systems and Decision Sciences, California State University, Fullerton, CA, USA. FAU - Brevers, Damien AU - Brevers D AD - Addictive and Compulsive Behaviour Lab (ACB-Lab), Department of Behavioural and Cognition Sciences, Campus Belval, University of Luxembourg, Esch-sur-Alzette, Luxembourg. FAU - Bechara, Antoine AU - Bechara A AD - Department of Psychology, and Brain and Creativity Institute, University of Southern California, Los Angeles, CA, USA. FAU - He, Qinghua AU - He Q AD - Faculty of Psychology, Southwest University, 2 Tiansheng Rd, Chongqing, China; Chongqing Collaborative Innovation Center for Brain Science, Chongqing, China; Southwest University Branch, Collaborative Innovation Center of Assessment Toward Basic Education Quality at Beijing Normal University, Chongqing, China; Institute of Psychology, Key Laboratory of Mental Health, Chinese Academy of Sciences, Beijing, China. Electronic address: heqinghua@swu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200314 PL - Netherlands TA - Behav Brain Res JT - Behavioural brain research JID - 8004872 SB - IM MH - Adult MH - Brain/pathology MH - Brain Mapping/methods MH - Cerebral Cortex/physiology MH - Cigarette Smoking/metabolism/*physiopathology MH - Craving/physiology MH - Cues MH - Gyrus Cinguli/pathology MH - Humans MH - Image Processing, Computer-Assisted/methods MH - Inhibition, Psychological MH - Magnetic Resonance Imaging MH - Male MH - Neural Pathways/physiology MH - Recurrence MH - Smokers/psychology MH - Smoking Cessation/*psychology MH - Substance Withdrawal Syndrome/psychology MH - Tobacco Use Disorder/metabolism/*physiopathology MH - Young Adult OTO - NOTNLM OT - ACC OT - Abstinent smoker OT - Response inhibition OT - Smoking cue OT - pre-SM EDAT- 2020/03/18 06:00 MHDA- 2021/08/25 06:00 CRDT- 2020/03/18 06:00 PHST- 2019/11/08 00:00 [received] PHST- 2020/02/16 00:00 [revised] PHST- 2020/02/19 00:00 [accepted] PHST- 2020/03/18 06:00 [pubmed] PHST- 2021/08/25 06:00 [medline] PHST- 2020/03/18 06:00 [entrez] AID - S0166-4328(20)30304-1 [pii] AID - 10.1016/j.bbr.2020.112605 [doi] PST - ppublish SO - Behav Brain Res. 2020 May 27;386:112605. doi: 10.1016/j.bbr.2020.112605. Epub 2020 Mar 14.