PMID- 32179117
OWN - NLM
STAT- MEDLINE
DCOM- 20210211
LR  - 20210211
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 154
DP  - 2020 Jul 1
TI  - Chitosan, magnetite, silicon dioxide, and graphene oxide nanocomposites: 
      Synthesis, characterization, efficiency as cisplatin drug delivery, and DFT 
      calculations.
PG  - 621-633
LID - S0141-8130(20)30835-7 [pii]
LID - 10.1016/j.ijbiomac.2020.03.106 [doi]
AB  - Drug delivery systems with controlled release have been considered important 
      tools for the treatment of various diseases. The efficacy of the drug can be 
      enhanced by increasing its solubility, stability, bioavailability, and specific 
      site delivery. Herein, we investigated cisplatin (cisP) loading efficacy and 
      release potentiality on chitosan (CS) functionalized with magnetite (M), silicon 
      dioxide (S), and graphene oxide (GO) nanoparticles. Different nanocomposites 
      [chitosan-coated magnetite, silicon dioxide, and graphene oxide (CS/M/S/GO); 
      chitosan-coated magnetite and silicon dioxide (CS/M/S); chitosan-coated silicon 
      dioxide (CS/S); and chitosan-coated magnetite (CS/M)] were prepared. The prepared 
      nanocomposites were characterized by X-ray diffraction (XRD), Fourier transform 
      infrared (FT-IR), scanning electron microscopy, transmission electron microscopy 
      (TEM) and energy-dispersive X-ray spectroscopy (EDS). DFT calculations were 
      employed to explore the interaction mechanism of cisP with a selected 
      chitosan-functionalized nanocomposite in the gas phase and water media. The 
      UV-Vis spectroscopy was used to study cisP loading and release from the prepared 
      nanocomposites. The results showed that the highest loading efficacy was achieved 
      by CS/M and CS/M/S/GO nanocomposites (87% and 84% respectively). While the 
      releasing potentiality for CS/M composite was the highest compared with the other 
      ones (91%).
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Abdel-Bary, Ahmed S
AU  - Abdel-Bary AS
AD  - Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 
      32512, Egypt.
FAU - Tolan, Dina A
AU  - Tolan DA
AD  - Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 
      32512, Egypt; Department of Chemistry, College of Science and Humanities, Prince 
      Sattam bin Abdulaziz University, Alkharj 11942, Saudi Arabia.
FAU - Nassar, Mostafa Y
AU  - Nassar MY
AD  - Department of Chemistry, Faculty of Science, Benha University, Benha 13518, 
      Egypt. Electronic address: m_y_nassar@fsc.bu.edu.eg.
FAU - Taketsugu, Tetsuya
AU  - Taketsugu T
AD  - Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 
      060-0810, Japan; Institute for Chemical Reaction Design and Discovery 
      (WPI-ICReDD), Hokkaido University, Sapporo 060-0810, Japan.
FAU - El-Nahas, Ahmed M
AU  - El-Nahas AM
AD  - Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 
      32512, Egypt. Electronic address: amelnahas@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20200313
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Drug Carriers)
RN  - 0 (graphene oxide)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 7782-42-5 (Graphite)
RN  - 9012-76-4 (Chitosan)
RN  - Q20Q21Q62J (Cisplatin)
RN  - XM0M87F357 (Ferrosoferric Oxide)
SB  - IM
MH  - Chitosan/*chemistry
MH  - Cisplatin/metabolism
MH  - Drug Carriers/*chemistry
MH  - Drug Liberation
MH  - Ferrosoferric Oxide/*chemistry
MH  - Graphite/*chemistry
MH  - Nanocomposites/*chemistry
MH  - Silicon Dioxide/*chemistry
OTO - NOTNLM
OT  - Cis-platin drug delivery
OT  - DFT calculations
OT  - Magnetic chitosan nanostructures
EDAT- 2020/03/18 06:00
MHDA- 2021/02/12 06:00
CRDT- 2020/03/18 06:00
PHST- 2020/01/26 00:00 [received]
PHST- 2020/03/10 00:00 [revised]
PHST- 2020/03/12 00:00 [accepted]
PHST- 2020/03/18 06:00 [pubmed]
PHST- 2021/02/12 06:00 [medline]
PHST- 2020/03/18 06:00 [entrez]
AID - S0141-8130(20)30835-7 [pii]
AID - 10.1016/j.ijbiomac.2020.03.106 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2020 Jul 1;154:621-633. doi: 10.1016/j.ijbiomac.2020.03.106. 
      Epub 2020 Mar 13.