PMID- 32179885
OWN - NLM
STAT- MEDLINE
DCOM- 20210712
LR  - 20210712
IS  - 1941-7225 (Electronic)
IS  - 0895-7061 (Linking)
VI  - 33
IP  - 7
DP  - 2020 Jul 18
TI  - Maternal Supplementation of Inositols, Fucoxanthin, and Hydroxytyrosol in 
      Pregnant Murine Models of Hypertension.
PG  - 652-659
LID - 10.1093/ajh/hpaa041 [doi]
AB  - BACKGROUND: Myoinositol (M) and D-chiro-inositol (D) are insulin sensitizer 
      compounds, while fucoxanthin (F) and hydroxytyrosol (H) are antioxidant 
      substances. We aim to investigate if the combination of these compounds, will 
      improve the vascular responses in pregnant mouse models of hypertension: a 
      genetic model, transgenic heterozygous mice lacking endothelial nitric oxide 
      synthase gene (eNOS-/+); and environmental, wild-type (WT) mice. Those mouse 
      models will allow a better understanding of the genetic/environmental 
      contribution to hypertension in pregnancy. METHODS: eNOS-/+ and WT female were 
      fed high fat diet for 4 weeks, then at 7-8 weeks of age were mated with WT male. 
      On gestational day (GD) 1, they were randomly allocated to receive MDFH treatment 
      or water as control: eNOS-/+ MDFH (n = 13), eNOS-/+ (n = 13), WT-MDFH (n = 14), 
      and WT (n = 20). Systolic blood pressure (SBP) was obtained at GD 18, then dams 
      were sacrificed; fetuses and placentas collected, and 2 mm segments of carotid 
      arteries isolated for vascular responses using the wire-myograph system. 
      Responses to phenylephrine (PE), with/without the NOS inhibitor 
      (N-nitro-l-arginine methyl ester (l-NAME)), and to acetylcholine (Ach) and sodium 
      nitroprussiate (SNP) were performed. RESULTS: SBP decreased in eNOS-/+ and WT 
      dams after MDFH supplementation. In eNOS-/+, MDFH lower the contractile response 
      to PE and l-NAME and improved Ach vasorelaxation. In WT dams, MDFH treatment did 
      not affect PE response; MDFH treatment lowered the vascular PE response after 
      incubation with l-NAME. No differences were seen in SNP relaxation in both 
      models. CONCLUSIONS: MDFH decreased SBP in both genetically and environmentally 
      hypertensive dams and improved vascular responses mostly in the eNOS-/+ dams.
CI  - (c) American Journal of Hypertension, Ltd 2020. All rights reserved. For 
      Permissions, please email: journals.permissions@oup.com.
FAU - Menichini, Daniela
AU  - Menichini D
AD  - Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical 
      School at The University of Texas Health Science Center at Houston (UTHealth), 
      Houston, Texas, USA.
AD  - International Doctorate School in Clinical and Experimental Medicine, Department 
      of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio 
      Emilia, Modena, Italy.
FAU - Alrais, Mesk
AU  - Alrais M
AD  - Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical 
      School at The University of Texas Health Science Center at Houston (UTHealth), 
      Houston, Texas, USA.
FAU - Liu, Chen
AU  - Liu C
AD  - Department of Biochemistry and Molecular Biology, UTHealth, Houston, Texas, USA.
FAU - Xia, Yang
AU  - Xia Y
AD  - Department of Biochemistry and Molecular Biology, UTHealth, Houston, Texas, USA.
FAU - Blackwell, Sean C
AU  - Blackwell SC
AD  - Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical 
      School at The University of Texas Health Science Center at Houston (UTHealth), 
      Houston, Texas, USA.
FAU - Facchinetti, Fabio
AU  - Facchinetti F
AD  - Unit of Obstetrics and Gynecology, Mother-Infant Department, University of Modena 
      and Reggio Emilia, Modena, Italy.
FAU - Sibai, Baha M
AU  - Sibai BM
AD  - Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical 
      School at The University of Texas Health Science Center at Houston (UTHealth), 
      Houston, Texas, USA.
FAU - Longo, Monica
AU  - Longo M
AD  - Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical 
      School at The University of Texas Health Science Center at Houston (UTHealth), 
      Houston, Texas, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Hypertens
JT  - American journal of hypertension
JID - 8803676
RN  - 0 (Antioxidants)
RN  - 0 (Xanthophylls)
RN  - 06O0TC0VSM (fucoxanthin)
RN  - 10597-60-1 (3,4-dihydroxyphenylethanol)
RN  - 4L6452S749 (Inositol)
RN  - ML9LGA7468 (Phenylethyl Alcohol)
SB  - IM
MH  - Animals
MH  - Antioxidants/*therapeutic use
MH  - Dietary Supplements
MH  - Disease Models, Animal
MH  - Drug Evaluation, Preclinical
MH  - Drug Therapy, Combination
MH  - Female
MH  - Hypertension/*drug therapy
MH  - Inositol/*therapeutic use
MH  - Mice
MH  - Mice, Knockout
MH  - Phenylethyl Alcohol/*analogs & derivatives/therapeutic use
MH  - Pregnancy
MH  - Random Allocation
MH  - Xanthophylls/*therapeutic use
OTO - NOTNLM
OT  - blood pressure
OT  - endothelial nitric oxide synthase
OT  - fucoxanthin
OT  - high fat diet
OT  - hydroxytyrosol
OT  - hypertension
OT  - inositol
OT  - obesity
OT  - pregnancy
EDAT- 2020/03/18 06:00
MHDA- 2021/07/13 06:00
CRDT- 2020/03/18 06:00
PHST- 2019/10/01 00:00 [received]
PHST- 2019/12/23 00:00 [revised]
PHST- 2020/03/11 00:00 [accepted]
PHST- 2020/03/18 06:00 [pubmed]
PHST- 2021/07/13 06:00 [medline]
PHST- 2020/03/18 06:00 [entrez]
AID - 5807972 [pii]
AID - 10.1093/ajh/hpaa041 [doi]
PST - ppublish
SO  - Am J Hypertens. 2020 Jul 18;33(7):652-659. doi: 10.1093/ajh/hpaa041.