PMID- 32181323
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 2352-9067 (Print)
IS  - 2352-9067 (Electronic)
IS  - 2352-9067 (Linking)
VI  - 27
DP  - 2020 Apr
TI  - Ability of FFR-CT to detect the absence of hemodynamically significant lesions in 
      patients with high-risk NSTE-ACS admitted in the emergency department with chest 
      pain, study design and rationale.
PG  - 100496
LID - 10.1016/j.ijcha.2020.100496 [doi]
LID - 100496
AB  - BACKGROUND: In the era of High-sensitive troponin (hs-Tn), up to 50% of patients 
      with a mild increase of hs-Tn will finally have a normal invasive coronary 
      angiogram. Fractional Flow Reserve (FFR) derived from coronary computed 
      tomographic angiography (FFR-CT) has never been used as a non-invasive tool for 
      the diagnosis of coronary artery disease in patients with high-risk acute 
      coronary syndrome without ST segment elevation (NSTE-ACS). AIMS: The study aims 
      to determine the role of coronary CT angiography and FFR-CT in the setting of 
      high-risk NSTE-ACS. METHODOLOGY: We will conduct a prospective trial, enrolling 
      250 patients admitted with high-risk NSTE-ACS who will rapidly undergo a coronary 
      CT angiography and then a coronary angiography with FFR measurements. Results of 
      coronary CT, FFR-CT and coronary angiography (+/- FFR) will be compared. POTENTIAL 
      SIGNIFICANCE: In conclusion, non-invasive identification of patients with 
      high-risk NSTE-ACS who could avoid coronary angiography would reduce procedure 
      related risks and medical costs.
CI  - (c) 2020 The Authors. Published by Elsevier B.V.
FAU - Meier, David
AU  - Meier D
AD  - Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland.
FAU - Skalidis, Ioannis
AU  - Skalidis I
AD  - Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland.
FAU - De Bruyne, Bernard
AU  - De Bruyne B
AD  - Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland.
AD  - Cardiovascular Center Aalst, Aalst, Belgium.
FAU - Qanadli, Salah Dine
AU  - Qanadli SD
AD  - Department of Radiology, Lausanne University Hospital, Lausanne, Switzerland.
FAU - Rotzinger, David
AU  - Rotzinger D
AD  - Department of Radiology, Lausanne University Hospital, Lausanne, Switzerland.
FAU - Eeckhout, Eric
AU  - Eeckhout E
AD  - Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland.
FAU - Collet, Carlos
AU  - Collet C
AD  - Cardiovascular Center Aalst, Aalst, Belgium.
FAU - Muller, Olivier
AU  - Muller O
AD  - Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland.
FAU - Fournier, Stephane
AU  - Fournier S
AD  - Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland.
AD  - Division of Cardiology, Department of Advanced Biomedical Sciences, University of 
      Naples Federico II, Italy.
LA  - eng
PT  - Journal Article
DEP - 20200305
PL  - Ireland
TA  - Int J Cardiol Heart Vasc
JT  - International journal of cardiology. Heart & vasculature
JID - 101649525
PMC - PMC7063126
OTO - NOTNLM
OT  - ACS, Acute coronary syndrome
OT  - AE, Adverse Event
OT  - Acute coronary syndrome
OT  - CMRI, Cardiac Magnetic resonance imaging
OT  - CT, Computed tomography
OT  - Coronary computed tomography
OT  - ECG, Electrocardiogram
OT  - ED, Emergency department
OT  - FFR, Fractional Flow Reserve
OT  - FFR-CT
OT  - FFR-CT, FFR derived from coronary CT
OT  - Fractional Flow Reserve
OT  - Hs-Tn, High-sensitive troponins
OT  - MACE, Major adverse cardiac events
OT  - MI, Myocardial infraction
OT  - NSTE-ACS, Acute coronary syndromes without ST-segment elevation
OT  - NSTEMI, Non-ST-elevation myocardial infarction
OT  - PCI, Percutaneous Coronary Intervention
OT  - STEMI, ST-elevation myocardial infarction
OT  - URL, Upper Range Limit
COIS- Dr Fournier reports an institutional consultancy for Bayer and Cathworks. Dr. De 
      Bruyne receives grant support from Abbott, Boston Scientific, Biotronik AG, and 
      St Jude Medical and receives consulting fees on behalf of Dr De Bruyne from St. 
      Jude Medical, Opsens, and Boston Scientific outside of the submitted work Dr. De 
      Bruyne is a shareholder for Siemens, GE, Bayer, Philips, HeartFlow, Edwards Life 
      Sciences, and Ceyliad. Dr. Collet reports receiving research grants from 
      Biosensor, Heart Flow Inc. and Abbott Vascular; and consultancy fees from Heart 
      Flow Inc, Abbott Vascular and Philips Volcano.
EDAT- 2020/03/18 06:00
MHDA- 2020/03/18 06:01
PMCR- 2020/03/05
CRDT- 2020/03/18 06:00
PHST- 2020/01/15 00:00 [received]
PHST- 2020/02/27 00:00 [accepted]
PHST- 2020/03/18 06:00 [entrez]
PHST- 2020/03/18 06:00 [pubmed]
PHST- 2020/03/18 06:01 [medline]
PHST- 2020/03/05 00:00 [pmc-release]
AID - S2352-9067(20)30043-9 [pii]
AID - 100496 [pii]
AID - 10.1016/j.ijcha.2020.100496 [doi]
PST - epublish
SO  - Int J Cardiol Heart Vasc. 2020 Mar 5;27:100496. doi: 10.1016/j.ijcha.2020.100496. 
      eCollection 2020 Apr.