PMID- 32181917
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231130
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 92
IP  - 12
DP  - 2020 Dec
TI  - Effectiveness and safety of direct-acting antivirals in hepatitis C infected 
      patients with mental disorders: Results in real clinical practice.
PG  - 3488-3498
LID - 10.1002/jmv.25772 [doi]
AB  - The aim of this study is to analyze the effectiveness and safety of direct-acting 
      antivirals (DAAs) in psychiatric patients with chronic hepatitis C (CHC). 
      Secondary objectives included adherence and drug-drug interaction (DDIs) 
      evaluations. Prospective observational comparative study carried out during 3 
      years. Psychiatric patients were included and mental illness classified by a 
      psychiatric team based on clinical records. Main effectiveness and safety 
      variables were sustained virologic response (SVR) at posttreatment week 12 
      (SVR12) and rate of on-treatment serious drug-related adverse events (AEs), 
      respectively. A total of 242 psychiatric and 900 nonpsychiatric patients were 
      included. SVR12 by intention-to-treat (ITT) analysis of psychiatric vs 
      nonpsychiatric patients was 92.6% (95% confidence interval [CI], 89.1-96.1) vs 
      96.2% (95% CI, 94.9-97.5) (P = .02). SVR12 by modified-ITT analysis was 97.8% 
      (95% CI, 95.0-99.3) vs 98.4% (95% CI, 97.5-99.3) (P = .74). 92.2% of psychiatric 
      patients with mental disorders secondary to multiple drug use (MDSDU) and 93.0% 
      of psychiatric patients without MDSDU vs 96.2% of nonpsychiatric patients reached 
      SVR12 (P = .05 and P = .20, respectively). The percentage of adherent patients to 
      DAAs did not show differences between cohorts (P = .08). 30.2% of psychiatric 
      patients and 27.6% of nonpsychiatric patients presented clinically relevant DDIs 
      (P = .47). 1.7% vs 0.8% of psychiatric vs nonpsychiatric patients developed 
      serious AEs (P = .39); no serious psychiatric AEs were present. DAAs have shown a 
      slightly lower effectiveness in psychiatric patients with CHC, as a result of 
      loss of follow up, which justifies the need for integrated and multidisciplinary 
      health care teams. DAAs safety, adherence, and DDIs, however, are similar to that 
      of nonpsychiatric patients.
CI  - (c) 2020 Wiley Periodicals, Inc.
FAU - Margusino-Framinan, Luis
AU  - Margusino-Framinan L
AUID- ORCID: 0000-0003-4309-1662
AD  - Pharmacy Service, Universitary Hospital of A Coruna, A Coruna, Spain.
AD  - Division of Clinical Virology, Biomedical Research Institute of A Coruna 
      (INIBIC), Universitary Hospital of A Coruna, SERGAS, University of A Coruna 
      (UDC), A Coruna, Spain.
FAU - Bobadilla-Perez, Eva
AU  - Bobadilla-Perez E
AD  - Psychiatry Service, Universitary Hospital of A Coruna, A Coruna, Spain.
FAU - Cid-Silva, Purificacion
AU  - Cid-Silva P
AD  - Pharmacy Service, Universitary Hospital of A Coruna, A Coruna, Spain.
AD  - Division of Clinical Virology, Biomedical Research Institute of A Coruna 
      (INIBIC), Universitary Hospital of A Coruna, SERGAS, University of A Coruna 
      (UDC), A Coruna, Spain.
FAU - Rodriguez-Sotelo, Alejandro
AU  - Rodriguez-Sotelo A
AD  - Psychiatry Service, Universitary Hospital of A Coruna, A Coruna, Spain.
FAU - Yanez-Rubal, Juan C
AU  - Yanez-Rubal JC
AD  - Pharmacy Service, Universitary Hospital of A Coruna, A Coruna, Spain.
FAU - Mena-de-Cea, Alvaro
AU  - Mena-de-Cea A
AD  - Division of Clinical Virology, Biomedical Research Institute of A Coruna 
      (INIBIC), Universitary Hospital of A Coruna, SERGAS, University of A Coruna 
      (UDC), A Coruna, Spain.
AD  - Infectious Diseases Unit, Internal Medicine Service, Universitary Hospital of A 
      Coruna, A Coruna, Spain.
FAU - Suarez-Lopez, Francisco
AU  - Suarez-Lopez F
AD  - Hepatology Unit, Digestive System Service, Universitary Hospital of A Coruna, A 
      Coruna, Spain.
FAU - Prieto-Perez, Andrea
AU  - Prieto-Perez A
AD  - Psychiatry Service, Universitary Hospital of A Coruna, A Coruna, Spain.
FAU - Gimenez-Arufe, Victor
AU  - Gimenez-Arufe V
AD  - Pharmacy Service, Universitary Hospital of A Coruna, A Coruna, Spain.
FAU - Delgado-Blanco, Manuel
AU  - Delgado-Blanco M
AD  - Division of Clinical Virology, Biomedical Research Institute of A Coruna 
      (INIBIC), Universitary Hospital of A Coruna, SERGAS, University of A Coruna 
      (UDC), A Coruna, Spain.
AD  - Hepatology Unit, Digestive System Service, Universitary Hospital of A Coruna, A 
      Coruna, Spain.
FAU - Sanclaudio-Luhia, Ana I
AU  - Sanclaudio-Luhia AI
AD  - Department of Information Systems, Universitary Hospital of A Coruna, A Coruna, 
      Spain.
FAU - Martin-Herranz, Isabel
AU  - Martin-Herranz I
AD  - Pharmacy Service, Universitary Hospital of A Coruna, A Coruna, Spain.
FAU - Castro-Iglesias, Angeles
AU  - Castro-Iglesias A
AD  - Division of Clinical Virology, Biomedical Research Institute of A Coruna 
      (INIBIC), Universitary Hospital of A Coruna, SERGAS, University of A Coruna 
      (UDC), A Coruna, Spain.
AD  - Infectious Diseases Unit, Internal Medicine Service, Universitary Hospital of A 
      Coruna, A Coruna, Spain.
LA  - eng
PT  - Journal Article
DEP - 20200328
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
SB  - IM
OTO - NOTNLM
OT  - chronic hepatitis C
OT  - clinical research
OT  - comparative effectiveness research
OT  - direct-acting antivirals
OT  - drug safety
OT  - mental disorders
EDAT- 2020/03/18 06:00
MHDA- 2020/03/18 06:01
CRDT- 2020/03/18 06:00
PHST- 2019/12/27 00:00 [received]
PHST- 2020/03/10 00:00 [accepted]
PHST- 2020/03/18 06:01 [medline]
PHST- 2020/03/18 06:00 [pubmed]
PHST- 2020/03/18 06:00 [entrez]
AID - 10.1002/jmv.25772 [doi]
PST - ppublish
SO  - J Med Virol. 2020 Dec;92(12):3488-3498. doi: 10.1002/jmv.25772. Epub 2020 Mar 28.