PMID- 32183869
OWN - NLM
STAT- MEDLINE
DCOM- 20210210
LR  - 20210210
IS  - 1743-422X (Electronic)
IS  - 1743-422X (Linking)
VI  - 17
IP  - 1
DP  - 2020 Mar 17
TI  - Isobavachalcone inhibits Pseudorabies virus by impairing virus-induced 
      cell-to-cell fusion.
PG  - 39
LID - 10.1186/s12985-020-01312-2 [doi]
LID - 39
AB  - Pseudorabies virus (PRV) is an important pathogen that threatens the global swine 
      industry. Currently, there is no effective drug that can clinically prevent or 
      treat PRV infections. Isobavachalcone (IBC), a natural chalcone compound derived 
      from Psoralea corylifolia, displays multiple biological activities, such as 
      antibacterial, antifungal, and anticancer activities. Recently, it was found that 
      IBC exhibited antiviral activity against an RNA virus, porcine reproductive and 
      respiratory syndrome virus (PRRSV), in vitro. In the current study, we further 
      demonstrated for the first time that IBC has a strong inhibitory effect on PRV. 
      Through a viral luciferase expression assay, we showed that the inhibition step 
      occurs mainly in the late stage of viral replication. Finally, via a cell-to-cell 
      fusion assay, we demonstrated that IBC inhibits PRV by blocking virus-mediated 
      cell fusion. Thus, IBC may be a candidate for further therapeutic evaluation 
      against PRV infection in vivo.
FAU - Wang, Yu
AU  - Wang Y
AD  - College of Veterinary Medicine, Northeast Agricultural University, Harbin, 
      150001, China.
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, 150001, China.
FAU - Liu, Tian-Xin
AU  - Liu TX
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, 150001, China.
FAU - Wang, Tong-Yun
AU  - Wang TY
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, 150001, China.
FAU - Tang, Yan-Dong
AU  - Tang YD
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, 150001, China. 
      tangyandong2008@163.com.
FAU - Wei, Ping
AU  - Wei P
AD  - College of Veterinary Medicine, Northeast Agricultural University, Harbin, 
      150001, China. weiping@neau.edu.cn.
LA  - eng
GR  - YQ2019C028/Heilongjiang Excellent Youth Fund Project/International
GR  - 2016YFD0500100/National Key R&D Program/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200317
PL  - England
TA  - Virol J
JT  - Virology journal
JID - 101231645
RN  - 0 (Antiviral Agents)
RN  - 0 (Chalcones)
RN  - 20784-50-3 (isobavachalcone)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/*pharmacology
MH  - *Cell Fusion
MH  - Cell Line
MH  - Chalcones/*pharmacology
MH  - Herpesvirus 1, Suid/*drug effects
MH  - Kidney/cytology
MH  - Swine
MH  - Virus Replication/*drug effects
PMC - PMC7079404
OTO - NOTNLM
OT  - Antiviral
OT  - Fusion
OT  - Isobavachalcone
OT  - PRV
COIS- The authors declare that they have no competing interests.
EDAT- 2020/03/19 06:00
MHDA- 2021/02/11 06:00
PMCR- 2020/03/17
CRDT- 2020/03/19 06:00
PHST- 2020/01/21 00:00 [received]
PHST- 2020/03/06 00:00 [accepted]
PHST- 2020/03/19 06:00 [entrez]
PHST- 2020/03/19 06:00 [pubmed]
PHST- 2021/02/11 06:00 [medline]
PHST- 2020/03/17 00:00 [pmc-release]
AID - 10.1186/s12985-020-01312-2 [pii]
AID - 1312 [pii]
AID - 10.1186/s12985-020-01312-2 [doi]
PST - epublish
SO  - Virol J. 2020 Mar 17;17(1):39. doi: 10.1186/s12985-020-01312-2.